ethyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-2-carboxylate

Base Information

• Chemical Name: ethyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-2-carboxylate
• CAS No.: 28731-96-6
• Molecular Formula: C11H11NO3S
• Molecular Weight: 237.279
• Mol file: 28731-96-6.mol

Synonyms:ethyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-carboxylate;ethyl 3,4-dihydro-3-oxo-2H-1,4-benzothiazine-2-carboxylate;ETHYL 3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-2-CARBOXYLATE;2-carboethoxy-1,4-benzothiazine-3-(1H)-one;2-ethoxycarbonyl-2H-1,4-benzothiazin-3(4H)-one;3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-2-carboxylic acid ethyl ester;ethyl 2,3-dihydro-3-oxo-4H-1,4-benzothiazine-2-caboxylate;

Chemical Property of ethyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-2-carboxylate

Chemical Property:

• PSA: 80.70000
• LogP: 1.80050

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

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Technology Process of ethyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-2-carboxylate

There total 6 articles about ethyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

diethyl 2-chloromalonate (14064-10-9) + 2-amino-benzenethiol (137-07-5) → 3-Oxo-3,4-dihydro-2H-1,4-benzothiazin-2-carbonsaeure-ethylester (28731-96-6)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 24h;

DOI:10.1002/jhet.5570400202

Reference yield: 89.0%

Diethyl 2-bromomalonate (685-87-0) + 2-amino-benzenethiol (137-07-5) → 3-Oxo-3,4-dihydro-2H-1,4-benzothiazin-2-carbonsaeure-ethylester (28731-96-6)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1248/cpb.38.1238

Reference yield: 42.0%

o,o'-Dithiobis(phenylcarbamoylessigsaeure-ethylester) (76542-06-8) → 3-Oxo-3,4-dihydro-2H-1,4-benzothiazin-2-carbonsaeure-ethylester (28731-96-6)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; at 40 ℃; for 2h; also with aqueous HCl;

upstream raw materials:

diethyl 2-chloromalonate

2-amino-benzenethiol

ethyl chlorocarbonylacetate

o,o'-Dithiobis(phenylcarbamoylessigsaeure-ethylester)

Downstream raw materials:

2-(3-Chloro-benzyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-2-carboxylic acid ethyl ester

2-(4-Chloro-benzyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-2-carboxylic acid ethyl ester

2-(3-Chloro-benzyl)-4H-benzo[1,4]thiazin-3-one

2-(4-chlorobenzyl)-2H-1,4-benzothiazin-3(4H)-one

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