N-[Cyclopentyl(tert-butoxycarbonyl)amino]phthalimide

Base Information

Chemical Name:N-[Cyclopentyl(tert-butoxycarbonyl)amino]phthalimide
CAS No.:287729-05-9
Molecular Formula:C18H22N2O4
Molecular Weight:330.384
Hs Code.:
DSSTox Substance ID:DTXSID701130467
Nikkaji Number:J1.225.605A
Mol file:287729-05-9.mol

Synonyms:DTXSID701130467;N-[Cyclopentyl(tert-butoxycarbonyl)amino]phthalimide;1,1-Dimethylethyl N-cyclopentyl-N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)carbamate;287729-05-9

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[Cyclopentyl(tert-butoxycarbonyl)amino]phthalimide

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:330.15795719
Heavy Atom Count:24
Complexity:510

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N(C1CCCC1)N2C(=O)C3=CC=CC=C3C2=O

Technology Process of N-[Cyclopentyl(tert-butoxycarbonyl)amino]phthalimide

There total 1 articles about N-[Cyclopentyl(tert-butoxycarbonyl)amino]phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-44-9
phthalic anhydride

: 287729-05-9
N-cyclopentyl-N-tert-butyloxycarbonylaminophthalimide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / tetrahydrofuran / 0.08 h / 20 °C

2: 82 percent / 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 1 h

3: acetic acid; triethylamine / tetrahydrofuran / 1 h / Heating

4: 85 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 - 5 °C

With acetic acid; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1: Acylation / 2: Cyclization / 3: Isomerization / 4: Alkylation;
DOI:10.1021/jo000225s

Reference yield: 85.0%

: 287729-05-9
N-cyclopentyl-N-tert-butyloxycarbonylaminophthalimide

: 259870-74-1
tert-butyl 1-cyclopentylhydrazinecarboxylate

Guidance literature:: With methylhydrazine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/S0040-4039(99)02038-9

Reference yield:

: 287729-05-9
N-cyclopentyl-N-tert-butyloxycarbonylaminophthalimide

: 24214-72-0,645372-27-6
cyclopentylhydrazine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / MeNHNH₂ / tetrahydrofuran / 24 h / 20 °C

2: HCl gas / diethyl ether

With hydrogenchloride; methylhydrazine; In tetrahydrofuran; diethyl ether; 1: dephthaloylation / 2: Substitution;
DOI:10.1016/S0040-4039(99)02038-9