Carbamic acid, [(1S)-1-[[[2-[[4-(cyclopentylmethoxy)phenyl]amino]ethyl]amino]carbonyl]- 3-methylbutyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-1-[[[2-[[4-(cyclopentylmethoxy)phenyl]amino]ethyl]amino]carbonyl]- 3-methylbutyl]-, phenylmethyl ester
CAS No.:289043-41-0
Molecular Formula:C28H39N3O4
Molecular Weight:481.635
Hs Code.:
Mol file:289043-41-0.mol

Synonyms:

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Chemical Property of Carbamic acid, [(1S)-1-[[[2-[[4-(cyclopentylmethoxy)phenyl]amino]ethyl]amino]carbonyl]- 3-methylbutyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Carbamic acid, [(1S)-1-[[[2-[[4-(cyclopentylmethoxy)phenyl]amino]ethyl]amino]carbonyl]- 3-methylbutyl]-, phenylmethyl ester

There total 6 articles about Carbamic acid, [(1S)-1-[[[2-[[4-(cyclopentylmethoxy)phenyl]amino]ethyl]amino]carbonyl]- 3-methylbutyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51388-20-6
4-benzyloxyaniline hydrochloride

: 289043-41-0
{(S)-1-[2-(4-Cyclopentylmethoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 20 percent / various solvent(s) / 16 h / 160 - 175 °C

2: 84 percent / N-ethyldiisopropylamine / dimethylformamide / 18 h / 20 °C

3: 98 percent / H₂ / Pd/C / methanol / 3 h / 20 °C

4: Ph₃P; DEAD / tetrahydrofuran

5: HCl / diethyl ether / 2 h / 20 °C

6: N-ethyldiisopropylamine / dimethylformamide / 16 h / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00344-5

Reference yield:

: 289044-51-5
(4-benzyloxy-phenyl)-(2-tert-butoxycarbonylamino-ethyl)-carbamic acid tert-butyl ester

: 289043-41-0
{(S)-1-[2-(4-Cyclopentylmethoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / H₂ / Pd/C / methanol / 3 h / 20 °C

2: Ph₃P; DEAD / tetrahydrofuran

3: HCl / diethyl ether / 2 h / 20 °C

4: N-ethyldiisopropylamine / dimethylformamide / 16 h / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00344-5

Reference yield:

: 2-aminoethyl-4-benzyloxyaniline hydrochloride

: 289043-41-0
{(S)-1-[2-(4-Cyclopentylmethoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / N-ethyldiisopropylamine / dimethylformamide / 18 h / 20 °C

2: 98 percent / H₂ / Pd/C / methanol / 3 h / 20 °C

3: Ph₃P; DEAD / tetrahydrofuran

4: HCl / diethyl ether / 2 h / 20 °C

5: N-ethyldiisopropylamine / dimethylformamide / 16 h / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00344-5