- Propantheline bromide
- Propantheline bromide
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| Name |
Propantheline bromide |
EINECS | 200-030-6 |
| CAS No. | 50-34-0 | Density | 1.2916 (rough estimate) |
| PSA | 35.53000 | LogP | 1.73480 |
| Solubility | water: >=10 g/100 mL at 21 °C | Melting Point |
159-161 °C |
| Formula | C23H30NO3.Br | Boiling Point | N/A |
| Molecular Weight | 448.4 | Flash Point | N/A |
| Transport Information | N/A | Appearance | white crystalline powder |
| Safety | 36 | Risk Codes | 22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
Lubricant Additives T2007B Polyisobutylene Succinic Anhydride;(2-Hydroxyethyl)diisopropylmethylammoniumbromide xanthene-9-carboxylate (6CI);Ammonium, (2-hydroxyethyl)diisopropylmethyl-, bromide,xanthene-9-carboxylate (8CI);Corrigast;Ercorax;Ercotina;Kivatin;Neo-Metantyl;Neopepulsan;Pantas;Pervagal;Pro-Banthine;Pro-Gastron;Prodixamon;Propantel;SC 3171;b-Diisopropylaminoethyl xanthene-9-carboxylatemethobromide; |
Propantheline bromide Synthetic route
| Conditions | Yield |
|---|---|
| With chloroform |
| Conditions | Yield |
|---|---|
| With water at 100℃; for 1.16667h; pH=7.0; Kinetics; Further Variations:; pH-values; |
- 16836-95-6
silver(I) 4-methylbenzenesulfonate
- 50-34-0
propantheline bromide
- 1107608-70-7
propantheline p-toluenesulfonate
| Conditions | Yield |
|---|---|
| In acetonitrile at 20℃; Darkness; |
Propantheline bromide Chemical Properties
Propantheline bromide ,its CAS register number is 50-34-0,it's called for Ammonium,diisopropyl(2-hydroxyethyl)methyl-,bromide,xanthene-9-carboxylate ; Diisopropyl(2-hydroxyethyl)methylammoniumbromidexanthene-9-carboxylate ; Ercorax ; Ercotina ; Iumbromide ; Ketaman ; Kivatin ; Nci-c56257 ; Pantheline ; Probantine ; Prodixamon ; Corrigast ,and so on. Propantheline bromide (CAS No.50-34-0) is usually white crystals or white powder.
IUPAC Name: Methyl-di(propan-2-yl)-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium bromide
CAS: 50-34-0
Molecular Formula: C23H30BrNO3
Molecular Weight: 448.39
Molecular structure:.gif)
EINECS: 200-030-6
Melting point: 159-161°C
Water solubility: >=10 g/100 mL at 21 ºC
ACD/LogD (pH 5.5): -1.77
ACD/LogD (pH 7.4): -1.77
ACD/BCF (pH 5.5): 1
ACD/BCF (pH 7.4): 1
ACD/KOC (pH 5.5): 2.61
ACD/KOC (pH 7.4): 2.61
H bond acceptors: 4
H bond donors: 0
Propantheline bromide Uses
1. Propantheline bromide (CAS No.50-34-0) is mainly used as an antimuscarinic agent for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, involuntary urination (enuresis), etc.
2. Propantheline bromide (CAS No.50-34-0) is also used to control the symptoms of irritable bowel syndrome and similar conditions.
Propantheline bromide Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | intravenous | 51mg/kg (51mg/kg) | Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 151, Pg. 614, 1957. | |
| mouse | LD50 | intraperitoneal | 60mg/kg (60mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969. | |
| mouse | LD50 | intravenous | 6400ug/kg (6.4mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA | Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959. |
| mouse | LD50 | oral | 445mg/kg (445mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 319, 1970. | |
| mouse | LD50 | subcutaneous | 128mg/kg (128mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969. | |
| rabbit | LD50 | oral | 750mg/kg (750mg/kg) | Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 36, 1973. | |
| rat | LD50 | intraduodenal | 125mg/kg (125mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
| rat | LD50 | intraperitoneal | 25mg/kg (25mg/kg) | Compilation of LD50 Values of New Drugs. | |
| rat | LD50 | intravenous | 4mg/kg (4mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959. |
| rat | LD50 | oral | 370mg/kg (370mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
| rat | LD50 | subcutaneous | 298mg/kg (298mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. |
RTECS: BP8249200
Propantheline bromide Safety Profile
Hazard Codes: Xn .gif){kind=small}
Risk Statements: 22 (R22:Harmful if swallowed.)
Safety Statements: 36 (S36:Wear suitable protective clothing.)
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