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Name	Pyridoxal hydrochloride	EINECS	200-602-5
CAS No.	65-22-5	Density	N/A
PSA	70.42000	LogP	1.20240
Solubility	Soluble in water and ethanol.	Melting Point	173 °C (dec.)(lit.)
Formula	C₈H₉NO₃^.HCl	Boiling Point	412.8 °C at 760 mmHg
Molecular Weight	203.625	Flash Point	203.5 °C
Transport Information	N/A	Appearance	White to off-white crystalline powder
Safety	24/25-22-36-26	Risk Codes	20/21/22-36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	4-Pyridinecarboxaldehyde,3-hydroxy-5-(hydroxymethyl)-2-methyl-, hydrochloride (9CI);Pyridoxal,hydrochloride (7CI,8CI);2-Methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridinehydrochloride;3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehydehydrochloride;3-Hydroxy-5-hydroxymethyl-2-methylisonicotinaldehyde hydrochloride;	Article Data	5

Pyridoxal hydrochloride Synthetic route

: 14029-59-5
Nα-(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethylene)-histidine

A: 65-22-5
pyridoxal hydrochloride

B: 71-00-1
L-histidine

Conditions

Conditions	Yield
With buffer solution In various solvent(s) at 25℃; Rate constant;

: 66-72-8
pyridoxal

: 65-22-5
pyridoxal hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 20℃; for 72h;

: 58-56-0
pyridoxal hydrochloride

: 65-22-5
pyridoxal hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; manganese(IV) oxide In water at 55℃; for 28h; Temperature;	88 g
With acetic acid; sodium nitrite In water at 5 - 20℃; for 2h; Reagent/catalyst; Solvent;
With hydrogenchloride; manganese(IV) oxide In water at 20℃; for 6h;

: 65-22-5
pyridoxal hydrochloride

: 89-25-8
edaravone

: 854010-13-2
1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol

Conditions

Conditions	Yield
With sodium carbonate In water at 10 - 20℃; pH=2.04; Reagent/catalyst; pH-value;	99%
With sodium hydroxide In water at 20℃; for 0.5h;	6.8%
With sodium hydroxide In water at 20 - 30℃; for 2h; pH=6.3 - 12.1; Time;

: 64-17-5
ethanol

: 65-22-5
pyridoxal hydrochloride

: 6151-12-8
1-ethoxy-7-hydroxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-5-ium chloride

Conditions

Conditions	Yield
at 60℃; for 2h;	99%
at 60℃; for 2h;	99%
for 1.5h; Reflux;	93%

: 65-22-5
pyridoxal hydrochloride

: 67-63-0
isopropyl alcohol

: 7-hydroxy-1-isopropoxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-5-ium chloride

Conditions

Conditions	Yield
at 60℃; for 2h;	99%

: 67-56-1
methanol

: 65-22-5
pyridoxal hydrochloride

: 7-hydroxy-1-methoxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-5-ium chloride

Conditions

Conditions	Yield
for 2h; Reflux;	98%

: 65-22-5
pyridoxal hydrochloride

: 107-15-3
ethylenediamine

: C18H22N4O4

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 1h; pH=6.5; Heating;	97%

: 65-22-5
pyridoxal hydrochloride

: 107-15-3
ethylenediamine

: 88969-07-7
N,N′-ethylenebis-(pyridoxylideneiminato)

Conditions

Conditions	Yield
Stage #1: pyridoxal hydrochloride With triethylamine In methanol Stage #2: ethylenediamine In methanol for 5h;	96.5%

: 1631-26-1
1-benzyl-1H-pyrrole-2,5-dione

: 5680-79-5
glycine ethyl ester hydrochloride

: 65-22-5
pyridoxal hydrochloride

: methyl (1R*,3S*,3aR*,6aS*)-5-benzyl-3-(3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)-4,6-dioxooctahydropyrrolo[3,4-c]pyrrole-1-carboxylate

Conditions

Conditions	Yield
With silver(I) acetate; triethylamine In ethanol at 70℃; diastereoselective reaction;	96%

Pyridoxal hydrochloride Chemical Properties

IUPAC Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4 carbaldehyde hydrochloride
The MF of 3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4 carbaldehyde hydrochloride (65-22-5) is C₈H₁₀ClNO₃.

The MW of 3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4 carbaldehyde hydrochloride (65-22-5) is 203.62.
Synonyms of 3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4 carbaldehyde hydrochloride (65-22-5): 4-Pyridinecarboxaldehyde, 3-hydroxy-5- (hydroxymethyl)-2-methyl-, hydrochloride ; Pyridoxal, hydrochloride ; 2-Methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine hydrochloride ; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde hydrochloride ; 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde, hydrochloride
Product Categories: Biochemistry;Vitamin Derivatives;Vitamins
Form: White to off-white crystalline powder
Flash Point: 203.5 °C
Boiling Point: 412.8 °C
Melting Point: 172-174 °C
Storage temp: -20 °C
Sensitive: Hygroscopic
EINECS: 200-602-5
Merck: 14,7978
BRN: 3656994

Pyridoxal hydrochloride Uses

3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4 carbaldehyde hydrochloride (65-22-5) is used as biochemical research and drug research, as a nutritional agent.

Pyridoxal hydrochloride Production

Pyridoxal oxime derived from vitamin B6 reacted with hydroxylamine hydrochloride,then reacted with the silver with reaction of nitrite.

Pyridoxal hydrochloride Toxicity Data With Reference

1.	orl-rat LD50:2150 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),922.
2.	scu-rat LD50:530 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),922.
3.	ivn-rat LD50:320 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),922.
4.	orl-mus LD50:1800 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),922.
5.	ipr-mus LD50:400 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD691-490 .
6.	scu-mus LD50:530 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),922.
7.	ivn-mus LD50:390 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),922.
8.	ivn-cat LD50:160 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),922.
9.	ims-cat LD50:152 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),922.
10.	ivn-rbt LD50:465 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research.

Pyridoxal hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Pyridoxal hydrochloride Safety Profile

Poison by intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NO_x and HCl. See also ALDEHYDES.
Safety information of 3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4 carbaldehyde hydrochloride (65-22-5):
Hazard Codes Xi
Risk Statements
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
24/25 Avoid contact with skin and eyes
22 Do not breathe dust
36 Wear suitable protective clothing
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany 2
RTECS UV1225000
F 8

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