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Name	Pyrrolidine,2-[diphenyl[(trimethylsilyl)oxy]methyl]-,(2R)-	EINECS	N/A
CAS No.	943757-71-9	Density	1.021 g/cm³
PSA	21.26000	LogP	4.86250
Solubility	N/A	Melting Point	N/A
Formula	C₂₀H₂₇NOSi	Boiling Point	412.7 °C at 760 mmHg
Molecular Weight	325.526	Flash Point	203.4 °C
Transport Information	N/A	Appearance	N/A
Safety	26	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	(diphenyl(trimethylsilyloxy)methyl)pyrrolidine;(2R)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine;diphenyl prolinol silyl ether;(2R)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine;(R)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine;(R)-α,α-Diphenylprolinol trimethylsilyl ether;

Pyrrolidine,2-[diphenyl[(trimethylsilyl)oxy]methyl]-,(2R)- Synthetic route

: 943757-71-9
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine

: 837-95-6
2-nitro-4-(trifluoromethyl)benzenesulfonyl chloride

: C27H29F3N2O5SSi

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	95%

: 943757-71-9
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: (R)-2-(diphenyl((trimethylsilyl)oxy)methyl)-1-((4-nitrophenyl)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	94%

: 943757-71-9
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine

: 162010-78-8
4-chlorosulfonyl-3-nitrobenzoic acid methyl ester

: C28H32N2O7SSi

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	93%

: 943757-71-9
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: (R)-2-(diphenyl((trimethylsilyl)oxy)methyl)-1-((2-nitrophenyl)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	92%

: 943757-71-9
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine

: 121-51-7
3-nitrobenzenesulphonyl chloride

: (R)-2-(diphenyl((trimethylsilyl)oxy)methyl)-1-((3-nitrophenyl)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	91%

: 943757-71-9
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine

: 18092-54-1
4-methoxy-2-nitrobenzenesulfonyl chloride

: C27H32N2O6SSi

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	90%

: 943757-71-9
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine

: 4533-96-4
4-chloro-2-nitrobenzenesulfonyl chloride

: C26H29ClN2O5SSi

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	88%

: 943757-71-9
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine

: 264224-82-0
(E)-4-methyl-2-(2-nitrovinyl)phenol

: 75-07-0
acetaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1631165-98-4
(-)-(E)-ethyl 3-((2S,3R,4R)-2,6-dimethyl-4-(nitromethyl)chroman-3-yl)acrylate

Conditions

Conditions	Yield
Stage #1: (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; (E)-4-methyl-2-(2-nitrovinyl)phenol; acetaldehyde In chloroform at -40 - -5℃; Wittig-Horner Reaction; Stage #2: ethyl (triphenylphosphoranylidene)acetate In chloroform at 20℃; for 2h;	87%

: 568586-10-7
4-fluoro-2-nitrobenzene-1-sulfonyl chloride

: 943757-71-9
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine

: C26H29FN2O5SSi

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	85%

: 943757-71-9
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine

: 61131-72-4
trans-4-bromo-2-(2-nitrovinyl)phenol

: 75-07-0
acetaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1631165-96-2
(-)-(E)-ethyl 3-((2S,3R,4R)-6-bromo-2-methyl-4-(nitromethyl)chroman-3-yl)acrylate

Conditions

Conditions	Yield
Stage #1: (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; trans-4-bromo-2-(2-nitrovinyl)phenol; acetaldehyde In chloroform at -40 - -5℃; Wittig-Horner Reaction; Stage #2: ethyl (triphenylphosphoranylidene)acetate In chloroform at 20℃; for 2h;	83%

Pyrrolidine,2-[diphenyl[(trimethylsilyl)oxy]methyl]-,(2R)- Specification

The Pyrrolidine,2-[diphenyl[(trimethylsilyl)oxy]methyl]-,(2R)-, with the CAS registry number 943757-71-9, has the systematic name of (2R)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine. It is also called (R)-α,α-Diphenylprolinol trimethylsilyl ether. And the molecular formula of this chemical is C₂₀H₂₇NOSi.

The physical properties of Pyrrolidine,2-[diphenyl[(trimethylsilyl)oxy]methyl]-,(2R)- are as following: (1)ACD/LogP: 5.29; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 2.2; (4)ACD/LogD (pH 7.4): 2.44; (5)ACD/BCF (pH 5.5): 4.97; (6)ACD/BCF (pH 7.4): 8.62; (7)ACD/KOC (pH 5.5): 14.46; (8)ACD/KOC (pH 7.4): 25.08; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 12.47 Å²; (13)Index of Refraction: 1.535; (14)Molar Refractivity: 99.29 cm³; (15)Molar Volume: 318.6 cm³; (16)Polarizability: 39.36×10^-24cm³; (17)Surface Tension: 33.8 dyne/cm; (18)Density: 1.021 g/cm³; (19)Flash Point: 203.4 °C; (20)Enthalpy of Vaporization: 66.54 kJ/mol; (21)Boiling Point: 412.7 °C at 760 mmHg; (22)Vapour Pressure: 5.06E-07 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O([Si](C)(C)C)C(c1ccccc1)(c2ccccc2)[C@@H]3NCCC3
(2)InChI: InChI=1/C20H27NOSi/c1-23(2,3)22-20(19-15-10-16-21-19,17-11-6-4-7-12-17)18-13-8-5-9-14-18/h4-9,11-14,19,21H,10,15-16H2,1-3H3/t19-/m1/s1
(3)InChIKey: RSUHWMSTWSSNOW-LJQANCHMBE

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