- RANITIDINE BISMUTH CITRATE
- Ranitidine Hcl
- Ranitidine hydrochloride
- Ranitidine hydrochloride
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Cas Database |
| Name |
Ranitidine hydrochloride |
EINECS | 275-207-4 |
| CAS No. | 71130-06-8 | Density | N/A |
| PSA | 111.56000 | LogP | 3.56600 |
| Solubility | H2O: 1.8 mg/mL | Melting Point |
N/A |
| Formula | C13H22N4O3S.HCl | Boiling Point | 437.1 °C at 760 mmHg |
| Molecular Weight | 350.87 | Flash Point | 218.2 °C |
| Transport Information | N/A | Appearance | tan solid |
| Safety | 22-24/25 | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-, hydrochloride; |
Article Data | 5 |
Ranitidine hydrochloride Chemical Properties
Molecular structure of Ranitidine hydrochloride (CAS NO.66357-35-5) is:
Product Name: Ranitidine hydrochloride
CAS Registry Number: 66357-35-5
IUPAC Name: (E)-1-N-[2-[[5-(dimethylaminomethyl)furan-2-yl]methylsulfanyl]ethyl]-1-N'-methyl-2-nitroethene-1,1-diamine
Product Categories: Active Pharmaceutical Ingredients
Empirical Formula: C13H22N4O3S
Molecular Weight: 314.4038
EINECS: 266-332-5
Appearance: white or light yellow crystalline powder, abnormal odor, taste bitter and astringent
Index of Refraction: 1.558
Molar Refractivity: 85.64 cm3
Molar Volume: 265.4 cm3
Surface Tension: 45 dyne/cm
Density: 1.184 g/cm3
Flash Point: 218.2 °C
Enthalpy of Vaporization: 69.37 kJ/mol
Boiling Point: 437.1 °C at 760 mmHg
Melting Point: 69-70 °C
log P (octanol-water): 0.27°C
Water Solubility: 2.47E+04 mg/L at 25 °C
Vapor Pressure: 1.20E-07 mm Hg at 25 °C
InChI: InChI=1/C13H22N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3/b13-9+
Smiles: c1(oc(CSCCN\C(=C\[N+](=O)[O-])NC)cc1)CN(C)C
Ranitidine hydrochloride Uses
Ranitidine hydrochloride (CAS NO.66357-35-5) can be used as Digestive system drugs ,Potent and long-acting histamine H2 receptor antagonist.
Ranitidine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 4286ug/kg/2D- (4.286mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | American Journal of Emergency Medicine. Vol. 17, Pg. 258, 1999. |
| man | TDLo | oral | 60mg/kg/14D-I (60mg/kg) | LIVER: "JAUNDICE, CHOLESTATIC" LIVER: LIVER FUNCTION TESTS IMPAIRED SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | American Journal of Gastroenterology. Vol. 93, Pg. 822, 1998. |
| mouse | LD50 | intramuscular | 280mg/kg (280mg/kg) | United States Patent Document. Vol. #4613602, | |
| mouse | LD50 | intravenous | 80mg/kg (80mg/kg) | United States Patent Document. Vol. #4613602, | |
| mouse | LD50 | oral | 884mg/kg (884mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 25, Pg. 749, 1990. | |
| rat | LD50 | intramuscular | 2018mg/kg (2018mg/kg) | United States Patent Document. Vol. #4613602, | |
| rat | LD50 | intravenous | 93mg/kg (93mg/kg) | United States Patent Document. Vol. #4613602, | |
| rat | LD50 | oral | > 5gm/kg (5000mg/kg) | United States Patent Document. Vol. #4613602, | |
| women | TDLo | oral | 12mg/kg/2D-I (12mg/kg) | KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS BLOOD: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER TOPICAL EXPOSURE" | American Journal of Emergency Medicine. Vol. 12, Pg. 67, 1994. |
Ranitidine hydrochloride Safety Profile
Safety Statements: 22-24/25
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
WGK Germany: 2
RTECS: KM6557000
Ranitidine hydrochloride Specification
Ranitidine hydrochloride (CAS NO.66357-35-5) is also called as 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro- ; MeSH Heading ; Ranitidine hydrochloride ; Ranitidine hydrochloride [USAN:INN:BAN] ; 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro- ; Achedos ; Acidex ; Atural ; Axoban ; Coralen ; Curan ; Duractin ; Ezopta ; Gastrial ; Gastrosedol ; Istomar ; Logast ; Major Ranitidine hydrochloride ; Mauran ; Microtid ; N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine ; Ptinolin ; Quantor ; Quicran ; RND ; Radinat ; Randin ; Ranidine ; Ranin ; Raniogas ; Ranisen ; Raniter ; Ranitidina ; Ranitidina [INN-Spanish] ; Ranitidinum [INN-Latin] ; Ranitiget ; Rantacid ; Ratic ; Raticina ; Sampep ; Taural ; Ul-Pep ; Ulceranin ; Urantac ; Verlost ; Vesyca ; Vizerul ; Weichilin ; Weidos ; Xanidine ; Zantab ; Zantadin .
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