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Name |
Rifamycin, 3-formyl- |
EINECS | 236-311-5 |
CAS No. | 13292-22-3 | Density | 1.37 g/cm3 |
PSA | 218.38000 | LogP | 4.70460 |
Solubility | N/A | Melting Point |
182-184°C |
Formula | C38H47NO13 | Boiling Point | 855.4 °C at 760 mmHg |
Molecular Weight | 725.79 | Flash Point | 471.1 °C |
Transport Information | N/A | Appearance | Black-Red Solid |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-8-carboxaldehyde,1,2-dihydro-5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-,21-acetate (7CI,8CI);3-Formylrifampicin SV;3-Formylrifamycin;3-Formylrifamycin SV;NCI 145-635;Rifaldehyde;Rifamycin AF; |
Article Data | 6 |
rifampicin
3-formylrifamycin SV
Conditions | Yield |
---|---|
With hydrogenchloride; water at 55℃; for 8h; Temperature; | 95% |
With hydrogenchloride; water In diethyl ether at 20℃; for 96h; | 89% |
With ascorbic acid In hydrogenchloride at 50℃; for 12h; | |
With isoniazid for 24h; |
rifampicin
3-formylrifamycin SV
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; water at 20℃; for 96h; | 88.9% |
3-formylrifamycin SV
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water pH=7; | 78.17 g |
3-formylrifamycin SV
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In water pH=7; | 76.34g |
N1-cinnamyl-N4-amino piperazine
3-formylrifamycin SV
Conditions | Yield |
---|---|
With acetic acid In ethanol at 20 - 30℃; for 2h; | 98% |
Conditions | Yield |
---|---|
With acetic acid In methanol at 40 - 52℃; for 0.5h; | 97.9% |
3-formylrifamycin SV
1-amino-4-(2-hydroxyethyl)-piperazine
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 0.25h; | 97% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 0.333333h; | 97% |
In tetrahydrofuran for 0.25h; | 94% |
In tetrahydrofuran at 20℃; for 0.25h; Schlenk technique; Inert atmosphere; | 91% |
Conditions | Yield |
---|---|
With acetic acid In methanol at 45 - 50℃; for 2h; | 91.5% |
Conditions | Yield |
---|---|
In pyridine for 2.75h; Ambient temperature; | 90% |
The Rifamycin, 3-formyl-, with CAS registry number 13292-22-3, belongs to the following product categories: (1)Various Metabolites and Impurities; (2)Intermediates & Fine Chemicals; (3)Metabolites & Impurities; (4)Pharmaceuticals. This chemical is a kind of black-red solid. Its classification code is Drug / Therapeutic Agent. And the chemical formula of this chemical is C38H47NO13. What's more, its EINECS is 236-311-5.
Physical properties of Rifamycin, 3-formyl-: (1)ACD/LogP: 2.85; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): 1.96; (4)ACD/LogD (pH 7.4): 0.24; (5)#H bond acceptors: 14; (6)#H bond donors: 6; (7)#Freely Rotating Bonds: 9; (8)Polar Surface Area: 218.38 Å2; (9)Index of Refraction: 1.633; (10)Molar Refractivity: 188.15 cm3; (11)Molar Volume: 526.5 cm3; (12)Polarizability: 74.58×10-24cm3; (13)Surface Tension: 68.8 dyne/cm; (14)Density: 1.37 g/cm3; (15)Flash Point: 508.3 °C; (16)Enthalpy of Vaporization: 139.67 kJ/mol; (17)Boiling Point: 916.9 °C at 760 mmHg; (18)Vapour Pressure: 0 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: CC(=O)OC1C(C)C(O)C(C)C(O)C(C)\C=C\C=C(\C)C(=O)Nc4c(C=O)c(O)c3c2C(=O)C(C)(O/C=C/C(OC)C1C)Oc2c(C)c(O)c3c4O
(2)InChI: InChI=1/C38H47NO13/c1-16-11-10-12-17(2)37(48)39-28-23(15-40)32(45)25-26(33(28)46)31(44)21(6)35-27(25)36(47)38(8,52-35)50-14-13-24(49-9)18(3)34(51-22(7)41)20(5)30(43)19(4)29(16)42/h10-16,18-20,24,29-30,34,42-46H,1-9H3,(H,39,48)/b11-10+,14-13+,17-12-
(3)InChIKey: BBNQHOMJRFAQBN-AEZIOYLSBJ
(4)Std. InChI: InChI=1S/C38H47NO13/c1-16-11-10-12-17(2)37(48)39-28-23(15-40)32(45)25-26(33(28)46)31(44)21(6)35-27(25)36(47)38(8,52-35)50-14-13-24(49-9)18(3)34(51-22(7)41)20(5)30(43)19(4)29(16)42/h10-16,18-20,24,29-30,34,42-46H,1-9H3,(H,39,48)/b11-10+,14-13+,17-12-
(5)Std. InChIKey: BBNQHOMJRFAQBN-AEZIOYLSSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 416mg/kg (416mg/kg) | United States Patent Document. Vol. #4002754, | |
mouse | LD50 | intravenous | 299mg/kg (299mg/kg) | "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977Vol. -, Pg. 531, 1977. | |
mouse | LD50 | oral | 907mg/kg (907mg/kg) | United States Patent Document. Vol. #4002754, |