Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Rosuvastatin
Related Products

Hot Products

Basic Information Post buying leads Suppliers Cas Database
Name

Rosuvastatin

 EINECS 689-191-5
CAS No. 287714-41-4 Density 1.368 g/cm3
PSA 149.30000 LogP 3.48250
Solubility N/A Melting Point 161.9 °C
Formula C22H28FN3O6S Boiling Point 745.6 °C at 760 mmHg
Molecular Weight 481.545 Flash Point 404.7 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 287714-41-4 (Rosuvastatin) Hazard Symbols N/A
Synonyms

(E)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methylsulfonyl)(methyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoicacid;6-heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (6E)-;

Article Data 30

Rosuvastatin Synthetic route

289042-12-2

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

287714-41-4

rosuvastatin

Conditions
ConditionsYield
Stage #1: 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester With acetic acid In tetrahydrofuran at 5 - 35℃;
Stage #2: With lithium hydroxide In tetrahydrofuran at 5 - 35℃;		93%
Stage #1: 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester With hydrogenchloride In water; acetonitrile at 35 - 40℃; for 4h; Inert atmosphere; Darkness;
Stage #2: With sodium hydroxide In acetonitrile at 20 - 25℃; for 2h;
Stage #3: With hydrogenchloride In water pH=3 - 4; Time;		74.4%
Stage #1: 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester With hydrogenchloride; water In methanol at 25℃;
Stage #2: With water; sodium hydroxide In methanol at 30℃; for 7.5 - 8.5h;
Stage #3: With hydrogenchloride In water pH=3.5 - 4;
1007871-85-3

tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate

287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 2h; Product distribution / selectivity;81%
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 2h; Product distribution / selectivity;81%
147118-40-9

(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester

287714-41-4

rosuvastatin

Conditions
ConditionsYield
Stage #1: (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester With ethanol; sodium hydroxide at 0 - 20℃;
Stage #2: With hydrogenchloride In water; ethyl acetate pH=3.5 - 4.0; Product distribution / selectivity;
Stage #1: (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester With water; sodium hydroxide In ethanol at 0 - 20℃;
Stage #2: With hydrogenchloride In ethanol; Isopropyl acetate; water Product distribution / selectivity;
Stage #1: (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester With sodium hydroxide; water In acetonitrile at 0 - 30℃; for 1.25h;
Stage #2: With hydrogenchloride; water at 0 - 5℃;

(E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)-(3R,5S)-3,5-dihydroxyhept-6-enoic acid, calcium salt

287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride In water; acetonitrile at 20℃; for 1h; Product distribution / selectivity;
With hydrogenchloride In water at 20℃; for 1h; Product distribution / selectivity;
852820-97-4

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidine-5-yl]-3,5-dihydroxyhept-6-enoic acid isopropylamine

287714-41-4

rosuvastatin

Conditions
ConditionsYield
With sodium hydroxide; water In ethanol at 20℃; for 2h;

crestor

287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride; sodium chloride In water; acetonitrile at 0 - 20℃; pH=2.8 - 3.4;
With monosodium salt of ethylenediaminetetraacetic acid In water
With hydrogenchloride In water; ethyl acetate at 20 - 25℃; pH=3.5 - 3.7; Product distribution / selectivity;
With hydrogenchloride; water In ethyl acetate for 0.166667h; Product distribution / selectivity;
With water; edetate disodium
355806-00-7

rosuvastatin tert-butyl ester

287714-41-4

rosuvastatin

Conditions
ConditionsYield
With sodium hydroxide; ethanol; water at 20℃; for 2h; Product distribution / selectivity;
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In tetrahydrofuran at 50 - 55℃; for 1h;
Stage #2: With phosphoric acid; water Product distribution / selectivity;
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In tetrahydrofuran at 30℃; for 2h;
Stage #2: With hydrogenchloride; water at 20℃; Product distribution / selectivity;
355805-96-8

rosuvastatin methylamine salt

287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride In water; ethyl acetate at 25 - 30℃; pH=4.0;
With hydrogenchloride; water In ethyl acetate at 25 - 30℃; pH=4.0;

rosuvastatin sodium

287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride; water at 20℃; Product distribution / selectivity;
With phosphoric acid; water In 2-methylpropyl acetate Product distribution / selectivity;
With hydrogenchloride In diethyl ether; water for 0.5h; pH=5; Product distribution / selectivity;
925705-14-2

rosuvastatin α,α-dimethylphenethyl ester

287714-41-4

rosuvastatin

Conditions
ConditionsYield
With sodium hydroxide; water In tetrahydrofuran at 50℃; for 3h;

Rosuvastatin Chemical Properties

Molecular Structure of Rosuvastatin (CAS NO.287714-41-4):

IUPAC Name: (E,3R,5R)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid 
Empirical Formula: C22H28FN3O6S
Molecular Weight: 481.5376
H bond acceptors: 9
H bond donors: 3
Freely Rotating Bonds: 12
Polar Surface Area: 116.3 Å2
Index of Refraction: 1.597
Molar Refractivity: 119.98 cm3
Molar Volume: 351.8 cm3
Surface Tension: 62.2 dyne/cm
Density: 1.368 g/cm3
Flash Point: 404.7 °C
Enthalpy of Vaporization: 114.08 kJ/mol
Boiling Point: 745.6 °C at 760 mmHg
Vapour Pressure: 2.38E-23 mmHg at 25°C
InChI
InChI=1/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17+/m0/s1
Smiles
c1(nc(N(S(=O)(=O)C)C)nc(c1\C=C\[C@@H](C[C@H](CC(O)=O)O)O)c1ccc(cc1)F)C(C)C
Classification Code: Anticholesteremic Agents; Antihyperlipidemic; Antilipemic Agents; Antimetabolites; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors

Rosuvastatin Specification

  Rosuvastatin , with CAS number of 287714-41-4, can be called (E)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methylsulfonyl)(methyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoicacid ; 6-heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (6E)- .

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 287714-41-4