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SCH 20569
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Name

SCH 20569

 EINECS N/A
CAS No. 56391-56-1 Density 1.32g/cm3
PSA 199.73000 LogP -0.31800
Solubility N/A Melting Point N/A
Formula C21H41 N5 O7 Boiling Point 684.3°Cat760mmHg
Molecular Weight 475.586 Flash Point 367.7°C
Transport Information N/A Appearance N/A
Safety Poison by intravenous, intramuscular, and subcutaneous routes. An experimental teratogen. Human systemic effects by intravenous route: changes to kidney, ureter and bladder. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. Risk Codes N/A
Molecular Structure Molecular Structure of 56391-56-1 (NETILMICIN) Hazard Symbols N/A
Synonyms

1-N-Ethylsisomicin;1-N-Ethylsisomycin; Netilmicin; Netromycin; Sch 20569

Article Data 4

SCH 20569 Chemical Properties

Molecular Formula: C21H41N5O7
Molar mass: 475.5795 g/mol
EINECS: 260-146-8
Density: 1.32 g/cm3
Flash Point: 367.7 °C
Index of Refraction: 1.597
Boiling Point: 684.3 °C at 760 mmHg
Vapour Pressure: 1.1E-21 mmHg at 25°C
Water solubility: Soluble
Appearance: White crystalline powder
Product categories of SCH 20569 (56391-56-1): Aminoglycoside antibiotics; Drugs; Antibiotics
Structure of SCH 20569 (56391-56-1):
            
XLogP3-AA: -4.2
H-Bond Donor: 8
H-Bond Acceptor: 12
Systematic Name: 2-[4-Amino-3-[[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-ethylamino-2-hydroxy-cyclohexoxy]-5-methyl-4-methylamino-tetrahydropyran-3,5-diol 
SMILES: O(C2C(O)C(OC1O\C(=C/CC1N)CN)C(N)CC2NCC)C3OCC(O)(C(NC)C3O)C 
InChI: InChI=1/C21H41N5O7/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3 
InChIKey: CIDUJQMULVCIBT-UHFFFAOYAD 
Std. InChI: InChI=1S/C21H41N5O7/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3 
Std. InChIKey: CIDUJQMULVCIBT-UHFFFAOYSA-N

SCH 20569 Uses

 SCH 20569 (56391-56-1) is similar to Antibacterial spectrum , Gentamicin , Tobramycin , west shuttle mycin , and, Amikacin . but it is more effective than Staphylococcus and Enteric bacteria ,but less for suppressing Pseudomonas aeruginosa and bacteria of Puluo Wei Marsden .It has been used for respiratory infections, skin and soft tissue infections, urinary tract infections, wound infections, bone and joint infections, postpartum infections, gastrointestinal tract and biliary tract infection, sepsis and so on.

SCH 20569 Production

Production of SCH 20569 (56391-56-1) is the reaction of fermentation: producing bacterium is Micromonospora inyoensis 155OF-1G, by fermentation of N-ethyl-α-deoxy-D-amine and purification.

SCH 20569 Toxicity Data With Reference

1.    

ivn-hmn TDLo:52 mg/kg/7D-C:KID

     CMAJAX    Canadian Medical Association Journal. 120 (1979),161.
2.    

ipr-rat LD50:231 mg/kg

     JJANAX    Japanese Journal of Antibiotics. 35 (1982),461.
3.    

scu-rat LD50:169 mg/kg

     JJANAX    Japanese Journal of Antibiotics. 35 (1982),461.
4.    

ivn-rat LD50:25,200 µg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 31 (1981),816.
5.    

ivn-mus LD50:22 mg/kg

     JJANAX    Japanese Journal of Antibiotics. 35 (1982),461.
6.    

ims-mus LD50:63,100 µg/kg

     JJANAX    Japanese Journal of Antibiotics. 35 (1982),461.
7.    

ims-mus LD50:63,100 µg/kg

     JJANAX    Japanese Journal of Antibiotics. 35 (1982),461.
8.    

scu-dog LDLo:500 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 31 (1981),816.
9.    

ims-dog LD50:125 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 31 (1981),816.
10.    

scu-mky LDLo:75 mg/kg

     JIDIAQ    Journal of Infectious Diseases. 137 (1978),476.
11.  

SCH 20569 Safety Profile

Poison by intravenous, intramuscular, and subcutaneous routes. An experimental teratogen. Human systemic effects by intravenous route: changes to kidney, ureter and bladder. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

SCH 20569 Specification

 SCH 20569 (56391-56-1) also can be called Netilmicin ; 1-N-Ethylsisomicin ; Netromycin and Netilmicin sulfate .

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