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SODIUM PRASTERONE SULFATE
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Name

SODIUM PRASTERONE SULFATE

 EINECS 214-152-2
CAS No. 1099-87-2 Density N/A
PSA 91.88000 LogP 4.44450
Solubility N/A Melting Point 148-149 °C (dec.)(lit.)
Formula C19H27NaO5S Boiling Point N/A
Molecular Weight 390.476 Flash Point 9℃
Transport Information N/A Appearance White to off-white powder
Safety 16-26-36/37/39-45 Risk Codes 11-34
Molecular Structure Molecular Structure of 1099-87-2 (Sodium prasterone sulfate) Hazard Symbols FlammableF, CorrosiveC
Synonyms

Teloin;Androst-5-en-17-one, 3b-hydroxy-, hydrogen sulfate, sodium salt(6CI,7CI,8CI);DHA-S;DHEA sulfate sodium salt;Dehydroepiandrosterone sulfatesodium salt;Dehydroisoandrosterone sulfate sodium salt;Mylis;NSC 72822;Prasterone sodium sulfate;Sodium dehydroepiandrosterone sulfate;Sodiumdehydroepiandrosterone-3-sulfate;Sodium prasterone sulfate;Androst-5-en-17-one,3-(sulfooxy)-, sodium salt, (3b)- (9CI);

Article Data 2

SODIUM PRASTERONE SULFATE Synthetic route

pyridinium salt of 3β-sulfooxy-androsten-(5)-one-(17)

pyridinium salt of 3β-sulfooxy-androsten-(5)-one-(17)

1099-87-2

Sodium prasterone sulfate

Conditions
ConditionsYield
With water; sodium chloride
53-43-0

dehydroepiandrosterone

1099-87-2

Sodium prasterone sulfate

Conditions
ConditionsYield
With pyridine; chlorosulfonic acid at 22℃; for 2h;
7647-01-0

hydrogenchloride

1099-87-2

Sodium prasterone sulfate

53-43-0

dehydroepiandrosterone

Conditions
ConditionsYield
at 25℃;
1099-87-2

Sodium prasterone sulfate

aqueous BaCl2

aqueous BaCl2

53-43-0

dehydroepiandrosterone

Conditions
ConditionsYield
at 100℃;

SODIUM PRASTERONE SULFATE Chemical Properties

IUPAC Name:sodium [(3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] sulfate (1099-87-2)
Synonyms : Sodium dehydroepiandrosterone-3-sulfate
Product Categories: 17-Ketosteroids;Biochemistry ; Steroids
Molecular Structure:   1099-87-2
Molecular Formula:  C19H27NaO5S
Molecular Weight : 390.47
CAS : 1099-87-2
EINECS:  214-152-2
Mol File: 1099-87-2.mol
Melting point: 148-149 °C (dec.)(lit.)
Refractive index : 10 ° (C=4, MeOH)
Solubility  methanol: clear to hazy
Appearance: Sodium prasterone sulfate (1099-87-2) is color  white to off-white powder
Merck : 2871

SODIUM PRASTERONE SULFATE Uses

 Sodium prasterone sulfate (1099-87-2) is used as endogenous adrenal androgens.

SODIUM PRASTERONE SULFATE Toxicity Data With Reference


 

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravaginal > 500mg/kg (500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 444, 1998.
mouse LD50 intraperitoneal 460mg/kg (460mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976.
mouse LD50 intravaginal > 500mg/kg (500mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 48, Pg. 189, 1994.
mouse LD50 intravenous 274mg/kg (274mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 687, 1982.
mouse LD50 subcutaneous 899mg/kg (899mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976.
rat LD50 intraperitoneal 523mg/kg (523mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976.
rat LD50 intravaginal > 500mg/kg (500mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 48, Pg. 189, 1994.
rat LD50 intravenous 468mg/kg (468mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976.
rat LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 687, 1982.
rat LD50 subcutaneous 1005mg/kg (1005mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976.
women TDLo intravenous 4mg/kg (4mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Japan Medical Gazette. Vol. 18(5), Pg. 10, 1981.

SODIUM PRASTERONE SULFATE Safety Profile

Hazard Codes : F,C
Risk Statements:  11-34
11:  Highly Flammable
34:  Sodium prasterone sulfate (1099-87-2) can causes burns.   
Safety Statements:  16-26-36/37/39-45
16:  Keep away from sources of ignition - No smoking
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection
WGK Germany:  3
RTECS : BV8397400

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