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Sodium gualenate

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Name

Sodium gualenate

EINECS 228-309-8
CAS No. 6223-35-4 Density N/A
PSA 65.58000 LogP 4.51650
Solubility N/A Melting Point 98°C(lit.)
Formula C15H17NaO3S Boiling Point N/A
Molecular Weight 300.354 Flash Point N/A
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 6223-35-4 (Sodium gualenate) Hazard Symbols N/A
Synonyms

1-Azulenesulfonicacid, 3,8-dimethyl-5-(1-methylethyl)-, sodium salt (9CI);1-Azulenesulfonicacid, 5-isopropyl-3,8-dimethyl-, sodium salt (7CI,8CI);Azulen SN;Azulene SN;Azunol ST;Azupromin;Guaiazulene 3-sulfonate sodium salt;Guaiazulene soluble;Sodium 1,4-dimethyl-7-isopropylazulene-3-sulfonate;Sodium3-methyl-5-isopropyl-8-methylazulenesulfonate;Sodium5-isopropyl-3,8-dimethyl-1-azulenesulfonate;Sodium7-isopropyl-1,4-dimethylazulene-3-sulfonate;Sodium guaiazulene-3-sulfonate;Sodium guaiazulenesulfonate;

Article Data 5

Sodium gualenate Synthetic route

489-84-9

7-isopropyl-1,4-dimethyl-azulene

6223-35-4

Azulon

Conditions
ConditionsYield
With sulfuric acid; acetic anhydride at 20℃; for 2h; Cooling with ice;87.5%
Stage #1: 7-isopropyl-1,4-dimethyl-azulene With sulfuric acid; acetic anhydride at 20℃; for 4h;
Stage #2: With sodium hydroxide In water
57%
Multi-step reaction with 2 steps
1: sulfuric acid; acetic anhydride / 3 h / 20 °C
2: sodium hydroxide
View Scheme
Stage #1: 7-isopropyl-1,4-dimethyl-azulene With sulfuric acid; acetic anhydride at 20℃; for 3h;
Stage #2: With sodium hydroxide
16915-32-5

5-isopropyl-3,8-dimethyl-azulene-1-sulfonic acid

6223-35-4

Azulon

Conditions
ConditionsYield
With sodium hydroxide
110-85-0

piperazine

6223-35-4

Azulon

1-((5-isopropyl-3,8-dimethylazulen-1-yl)sulfonyl)piperazine

Conditions
ConditionsYield
Stage #1: Azulon With pyridine; oxalyl dichloride In dichloromethane
Stage #2: piperazine With pyridine; triethylamine
43%
6223-35-4

Azulon

1338350-96-1

N-ethyl-3,8-dimethyl-5-isopropyl-1-azulene sulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / Cooling with ice
2: pyridine; triethylamine / dichloromethane / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; pyridine; oxalyl dichloride / dichloromethane / Cooling with ice
2: triethylamine; pyridine / dichloromethane / 1 h / 20 °C
View Scheme
6223-35-4

Azulon

1338350-97-2

N-cyclohexyl-3,8-dimethyl-5-isopropyl-1-azulene sulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / Cooling with ice
2: pyridine; triethylamine / dichloromethane / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; pyridine; oxalyl dichloride / dichloromethane / Cooling with ice
2: triethylamine; pyridine / dichloromethane / 1 h / 20 °C
View Scheme
6223-35-4

Azulon

1338350-98-3

N-benzyl-3,8-dimethyl-5-isopropyl-1-azulene sulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / Cooling with ice
2: pyridine; triethylamine / dichloromethane / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; pyridine; oxalyl dichloride / dichloromethane / Cooling with ice
2: triethylamine; pyridine / dichloromethane / 1 h / 20 °C
View Scheme
6223-35-4

Azulon

1338350-99-4

N-(4-chlorophenyl)-3,8-dimethyl-5-isopropyl-1-azulene sulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / Cooling with ice
2: pyridine; triethylamine / dichloromethane / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; pyridine; oxalyl dichloride / dichloromethane / Cooling with ice
2: triethylamine; pyridine / dichloromethane / 1 h / 20 °C
View Scheme
6223-35-4

Azulon

1338351-00-0

N-(4-aminophenyl)-3,8-dimethyl-5-isopropyl-1-azulene sulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / Cooling with ice
2: pyridine; triethylamine / dichloromethane / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; pyridine; oxalyl dichloride / dichloromethane / Cooling with ice
2: triethylamine; pyridine / dichloromethane / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / dichloromethane / 4 h / 0 °C
2: dichloromethane / 12 h
3: trifluoroacetic acid / dichloromethane / 3 h
View Scheme
6223-35-4

Azulon

1338351-02-2

N-[4-(benzylideneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / Cooling with ice
2: pyridine; triethylamine / dichloromethane / 1 h / 20 °C
3: ethanol / 1 h / 20 °C
View Scheme
6223-35-4

Azulon

1338351-03-3

N-[4-(2-hydroxybenzylideneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / Cooling with ice
2: pyridine; triethylamine / dichloromethane / 1 h / 20 °C
3: ethanol / 1 h / 20 °C
View Scheme

Sodium gualenate Chemical Properties

Molecular Structure:

Molecular Formula: C15H17NaO3S
Molecular Weight: 300.3484
IUPAC Name: Sodium 3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate
Synonyms of Sodium gualenate (CAS NO.6223-35-4): 3,8-Dimethyl-5-(1-methylethyl)-1-azulenesulfonic acid sodium salt ; Azulen SN ; Azulon ; Azupromin ; CCRIS 3781 ; EINECS 228-309-8 ; Guajazulen-3-sulfonsaeure, natriumsalz ; Gualenate de sodium ; Gualenate de sodium [INN-French] ; Gualenato sodico ; Gualenato sodico [INN-Spanish] ; Gualenato sodidico ; Natrii gualenas ; Natrii gualenas [INN-Latin] ; Natrium 7-isopropyl-1,4-dimethyl-3-azulensulfonat ; Sodium 5-isopropyl-3,8-dimethyl-1-azulene sulfonate ; Sodium 7-isopropyl-1,4-dimethylazulene-3-sulfonate ; Sodium guaiazulene-3-sulfonate ; UNII-19WSH095WP ; 1-Azulenesulfonic acid, 3,8-dimethyl-5-(1-methylethyl)-, sodium salt (9CI) ; 1-Azulenesulfonic acid, 5-isopropyl-3,8-dimethyl-, sodium salt ; Azuletil sodium
CAS NO: 6223-35-4
Product Categories: Drug / Therapeutic Agent

Sodium gualenate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 105mg/kg (105mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Shinryo to Shinyaku. Medical Consultation and New Remedies. Vol. 11, Pg. 2533, 1974.
mouse LD50 oral 1540mg/kg (1540mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 615, 1969.
mouse LD50 subcutaneous 145mg/kg (145mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Shinryo to Shinyaku. Medical Consultation and New Remedies. Vol. 11, Pg. 2533, 1974.
rat LD50 intraperitoneal 180mg/kg (180mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Shinryo to Shinyaku. Medical Consultation and New Remedies. Vol. 11, Pg. 2533, 1974.
rat LD50 oral 6380mg/kg (6380mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 615, 1969.
rat LD50 subcutaneous 520mg/kg (520mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Shinryo to Shinyaku. Medical Consultation and New Remedies. Vol. 11, Pg. 2533, 1974.

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