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Sodium picosulfate
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Name

Sodium picosulfate

 EINECS 233-120-9
CAS No. 10040-45-6 Density N/A
PSA 162.51000 LogP 4.10140
Solubility N/A Melting Point 272 - 275oC
Formula C18H13NNa2O8S2 Boiling Point N/A
Molecular Weight 481.415 Flash Point N/A
Transport Information N/A Appearance gray powder complex
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 10040-45-6 (Sodium picosulfate) Hazard Symbols N/A
Synonyms

Phenol,4,4'-(2-pyridinylmethylene)bis-, bis(hydrogen sulfate) (ester), disodium salt(9CI);Phenol, 4,4'-(2-pyridylmethylene)di-, bis(hydrogen sulfate) (ester)disodium salt (8CI);4,4'-(2-Pyridylmethylene)diphenol bis(hydrogen sulfate)disodium salt;DA 1773;Disodium bis[4-[(hydroxysulfonyl)oxy]phenyl](2-pyridyl)methane;Evacuol;Guttalax;Guttalax-Fher;LA 391;Laxoberal;Laxoberon;Neopax;Pico-Salax;Picolax;Picosulfate sodium;Picosulfol;Rapilax;Sodiumpicosulfate;

 

Sodium picosulfate Synthetic route

603-41-8

4,4'-(2-pyridylmethylene)diphenol

10040-45-6

Guttalax

Conditions
ConditionsYield
Stage #1: 4,4'-(2-pyridylmethylene)diphenol With pyridine; chlorosulfonic acid at 0 - 20℃; for 5h;
Stage #2: With sodium hydroxide Concentration; Cooling with ice;		86.4%
Stage #1: 4,4'-(2-pyridylmethylene)diphenol With pyridine; chlorosulfonic acid at 35 - 40℃; for 3h; Flow reactor;
Stage #2: With sodium hydroxide		59.9%
Stage #1: 4,4'-(2-pyridylmethylene)diphenol With pyridine; chlorosulfonic acid at 10 - 25℃; for 12h; Inert atmosphere; Large scale;
Stage #2: With water; sodium hydroxide at 0℃; pH=11; pH-value; Inert atmosphere; Large scale;		2.1 kg
104-92-7

1-bromo-4-methoxy-benzene

10040-45-6

Guttalax

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Inert atmosphere; Large scale
1.2: 4 h / 10 - 20 °C / Inert atmosphere; Large scale
2.1: hydrogen iodide; acetic acid / 6 h / 100 °C / Large scale
3.1: pyridine; chlorosulfonic acid / 12 h / 10 - 25 °C / Inert atmosphere; Large scale
3.2: 0 °C / pH 11 / Inert atmosphere; Large scale
View Scheme
2524-52-9

ethyl-2-picolinate

10040-45-6

Guttalax

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Inert atmosphere; Large scale
1.2: 4 h / 10 - 20 °C / Inert atmosphere; Large scale
2.1: hydrogen iodide; acetic acid / 6 h / 100 °C / Large scale
3.1: pyridine; chlorosulfonic acid / 12 h / 10 - 25 °C / Inert atmosphere; Large scale
3.2: 0 °C / pH 11 / Inert atmosphere; Large scale
View Scheme
10040-45-6

Guttalax

7585-39-9

β‐cyclodextrin

C18H13NO8S2(2-)*2Na(1+)*C42H70O35

Conditions
ConditionsYield
In water at 25℃;
10040-45-6

Guttalax

51264-33-6

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate

Conditions
ConditionsYield
With water at 40℃; for 730.5h; Temperature;
10040-45-6

Guttalax

A

51264-33-6

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate

B

603-41-8

4,4'-(2-pyridylmethylene)diphenol

Conditions
ConditionsYield
With water at 40℃; for 730.5h;
10040-45-6

Guttalax

A

51264-33-6

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate

B

603-41-8

4,4'-(2-pyridylmethylene)diphenol

C

(hydroxy(pyridin-2-yl)methylene)bis(4,1-phenylene) bis(sulfate)

Conditions
ConditionsYield
With water at 40℃; for 4383h; Temperature;
10040-45-6

Guttalax

A

51264-33-6

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate

B

(hydroxy(pyridin-2-yl)methylene)bis(4,1-phenylene) bis(sulfate)

Conditions
ConditionsYield
With water at 40℃; for 2191.5h; pH=4.5; pH-value; Temperature;

Sodium picosulfate Chemical Properties


IUPAC Name: disodium [4-[Pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate
Canonical SMILES: C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+]
InChI: InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2
EINECS: 233-120-9 
Empirical Formula: C18H13NNa2O8S2
Molecular Weight: 481.4073 
Classification Code of Sodium picosulfate (CAS NO.10040-45-6): Cathartics; Drug / Therapeutic Agent; Gastrointestinal Agents; Reproductive Effect

Sodium picosulfate Uses

 Sodium picosulfate (CAS NO.10040-45-6) is a laxative and is generally used for emergency evacuation of the bowel, usually for patients who are preparing to undergo a colonoscopy. It is usually a lemon flavour and has to be dissolved into a glass of water. It works very quickly, so access to a toilet at all times is recommended. It starts off just by making your bowel movements looser and more frequent, but within an hour or so of taking it the patient should experience diarrhoea. The most common side effects of Sodium picosulfate  are abdominal cramps and diarrhoea. The use of Sodium picosulfate has also been associated with certain electrolyte disturbances, such as hyponatremia and hypokalemia.

Sodium picosulfate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2900mg/kg (2900mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
mouse LD50 intravenous 1600mg/kg (1600mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
mouse LD50 oral 14500mg/kg (14500mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
mouse LD50 subcutaneous 6420mg/kg (6420mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Nara Igaku Zasshi. Journal of the Nara Medical Association. Vol. 28, Pg. 258, 1977.
rat LD50 intraperitoneal 3gm/kg (3000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
rat LD50 intravenous 1450mg/kg (1450mg/kg) BEHAVIORAL: ATAXIA Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
rat LD50 oral 11300mg/kg (11300mg/kg)   Drugs in Japan Vol. -, Pg. 993, 1995.
rat LD50 subcutaneous 6980mg/kg (6980mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: COMA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Nara Igaku Zasshi. Journal of the Nara Medical Association. Vol. 28, Pg. 258, 1977.

Sodium picosulfate Specification

  Sodium picosulfate (CAS NO.10040-45-6), its Synonyms are 2-Picolylidenebis(p-phenyl sodium sulfate) ; 4,4'-(2-Picolylidene)bis(phenylsulfuric acid) disodium salt ; 4,4'-(2-Pyridinylmethylene)bisphenol bis(hydrogen sulfate)(ester) disodium salt ; 4,4'-(2-Pyridylmethylene)diphenolbis(hydrogen sulfate) (ester) disodium salt ; DA-1773 ; Disodium 4,4'-disulfoxydiphenyl-(2-pyridyl)methane ; Picosulfate sodium ; Picosulfato sodico .

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