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Streptomycin sulfate

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Name

Streptomycin sulfate

EINECS 223-286-0
CAS No. 3810-74-0 Density 1.2302 (rough estimate)
PSA 911.80000 LogP -8.65400
Solubility Water solubility: 0.1 g/mL, clear Melting Point N/A
Formula C42H84N14O36S3 Boiling Point 948.2 °C at 760 mmHg
Molecular Weight 1457.4 Flash Point 527.3 °C
Transport Information N/A Appearance White to off-white powder
Safety 26-36 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 3810-74-0 (Streptomycin sulfate) Hazard Symbols HarmfulXn,IrritantXi
Synonyms

D-Streptamine,O-2-deoxy-2-(methylamino)-a-L-glucopyranosyl-(1?;4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)(9CI);Streptomycin, sulfate (2:3) (salt) (8CI);Ag Streptomycin;Agri-Strep;Agrimycin 17;Agrimycin sulfate;Ambistryn S;Hortocyna;KeyStrepto;Strepto;Streptobrettin;Streptomycinsesquisulfate;Streptomycin sesquisulphate;Streptonex;Strycin;

 

Streptomycin sulfate Chemical Properties

Synonyms: N,N'''-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (2:3) (salt) ; Agristrep ; Ambistryn S ; Bis-(4-O-(2-O-(2-desoxy-2-methylamino-alpha-L-glucopyranosyl)-alpha-L-streptosyl)-L-streptidin)-trisulfat
Molecular Formula: C42H84N14O36S3
Molecular Weight: 1457.3836 
EINECS: 223-286-0
Flash Point: 527.3 °C
Enthalpy of Vaporization: 156.55 kJ/mol
Boiling Point: 948.2 °C at 760 mmHg
Storage tempreture: 2-8 °C
Water solubility: 0.1 g/mL, clear
Appearance: White to off-white powder
Structure of Streptomycin sulfate (CAS NO.3810-74-0):
                   
IUPAC Name: 2-[3-(Diaminomethylideneamino)-4-[3-[4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine ; Sulfuric acid
Canonical SMILES: CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O
InChI: InChI=1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)
InChIKey: QTENRWWVYAAPBI-UHFFFAOYSA-N
Product Category of Streptomycin sulfate (CAS NO.3810-74-0): Aminoglycosides (Antibiotics for Research and Experimental Use);Biochemistry;Antibiotic Explorer;Chemical Structure;Fungicides;Pesticides;Principle;Peptide Synthesis/Antibiotics

Streptomycin sulfate Uses

 Streptomycin sulfate (CAS NO.3810-74-0) has been used for infection of infective endocarditis, plague and tularemia, influenza bacilli and gram-negative bacteria caused by TB, Brucella and non-hemolytic Bacillus hammer.

Streptomycin sulfate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 oral 400mg/kg (400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 14, Pg. 510, 1969.
infant TDLo intraperitoneal 170mg/kg (170mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
British Medical Journal. Vol. 1, Pg. 557, 1961.
mouse LD50 intravenous 90200ug/kg (90.2mg/kg)   Antibiotiki. Vol. 18, Pg. 444, 1973.
mouse LD50 oral 430mg/kg (430mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982.
mouse LD50 subcutaneous 403mg/kg (403mg/kg)   Antibiotics Annual. Vol. 4, Pg. 574, 1956/1957.
rat LD50 oral 430mg/kg (430mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982.
rat LD50 subcutaneous 600mg/kg (600mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 597, 1962.

 

Streptomycin sulfate Safety Profile

Moderately toxic by ingestion and subcutaneous routes. Human teratogenic effects by intramuscular route: developmental abnormalities of the eye and ear. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also STREPTOMYCIN and SULFATES.

Streptomycin sulfate Specification

 Streptomycin sulfate , ever using CAS.: 298-39-5, its cas register number is 3810-74-0.

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