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Name |
Sulfathiazole sodium |
EINECS | 205-638-5 |
CAS No. | 144-74-1 | Density | N/A |
PSA | 112.91000 | LogP | 3.04690 |
Solubility | N/A | Melting Point |
175oC (form a); 202oC (form b) |
Formula | C9H8N3NaO2S2 | Boiling Point | 479.5 °C at 760 mmHg |
Molecular Weight | 277.303 | Flash Point | 243.8 °C |
Transport Information | N/A | Appearance | N/A |
Safety | 26-36-24/25-23 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
Benzenesulfonamide,4-amino-N-2-thiazolyl-, monosodium salt (9CI);Sodium norsulfazole;Sodium sulfathiazolate;Norsulfazole soluble;Sodium sulfathiazole;Soluble norsulfazole;Solublesulfathiazole;Soluthiazomide;Sulfathiazole sodium salt;Sulphathiazole sodium;2-(p-Amino-N-sodiobenzenesulfonamide)thiazole;2-(p-Aminobenzenesulfonamido)thiazole sodium salt;2-Sulfanilamidothiazolesodium salt;Norsulfazol sodium;Sodium 2-sulfanilamidothiazole;Norsulfazole sodium;Norsulfazole sodium salt; |
Article Data | 1 |
Conditions | Yield |
---|---|
at 20℃; | 97% |
Conditions | Yield |
---|---|
In methanol pptn. on addn. of Cu-salt to warm soln. of 2 equiv. ligand (stirring); collection (filtration), drying; elem. anal.; | 90% |
sulfathiazole sodium
Conditions | Yield |
---|---|
In water aq. soln. of CoCl2 was added to 2.2 equiv. of S-compd. in H2O, stirring at room temp.; standing for 4 d, solid was centrifuged off, washed with H2O several times, dried (vac., away from light), elem. anal.; liq. was stood for 7-12 d, crystals were centrifuged off, washed with H2O several times, dried (vac., away from light), elem. anal.; | A 88.6% B 88% |
sulfathiazole sodium
methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate
Conditions | Yield |
---|---|
In acetic acid for 0.333333h; Reflux; | 78% |
Conditions | Yield |
---|---|
In methanol for 4h; Reflux; | 60% |
(E)-3-(4-methoxyphenyl)propenoyl chloride
sulfathiazole sodium
Conditions | Yield |
---|---|
With pyridine In tetrahydrofuran for 25.5h; Cooling with ice; | 55% |
Conditions | Yield |
---|---|
at 85 - 150℃; Kinetics; |
sulfathiazole sodium
chlorothio-trichloro-methane
4-amino-N-thiazol-2-yl-N-trichloromethylsulfanyl-benzenesulfonamide
Conditions | Yield |
---|---|
In benzene Heating; |
Reported in EPA TSCA Inventory.
The Sulfathiazole sodium, with the CAS registry number 144-74-1, is also known as Benzenesulfonamide, 4-amino-N-2-thiazolyl-, sodium salt (1:1). It belongs to the classification code of Drug / Therapeutic Agent. Its EINECS registry number is 205-638-5. This chemical's molecular formula is C9H8N3NaO2S2 and molecular weight is 277.30. What's more, both its IUPAC name and systematic name are the same which is called Sodium (4-aminophenyl)sulfonyl-(1,3-thiazol-2-yl)azanide. It is a sulfonamide for the treatment of infection in susceptible strains.
Physical properties about Sulfathiazole sodium are: (1)ACD/LogP: 0.05; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.04; (4)ACD/LogD (pH 7.4): -0.26; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 24.92; (8)ACD/KOC (pH 7.4): 12.59; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 98.92 Å2; (13)Flash Point: 243.8 °C; (14)Enthalpy of Vaporization: 74.38 kJ/mol; (15)Boiling Point: 479.5 °C at 760 mmHg; (16)Vapour Pressure: 2.35E-09 mmHg at 25 °C.
When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin, eyes and respiratory system or other mucous membranes. Therefore, you should wear suitable protective clothing. You can not breathe the gas/fumes/vapour/spray and you should avoid contacting with skin and eyes. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1) SMILES: [Na+].O=S(=O)([N-]c1nccs1)c2ccc(N)cc2
(2) InChI: InChI=1S/C9H8N3O2S2.Na/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;/h1-6H,10H2;/q-1;+1
(3) InChIKey: GWIJGCIVKLITQK-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 1320mg/kg (1320mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 284, 1944. | |
mouse | LD50 | intravenous | 708mg/kg (708mg/kg) | Journal of the Indiana State Medical Association. Vol. 33, Pg. 503, 1940. | |
mouse | LD50 | oral | 3800mg/kg (3800mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 338, 1953. | |
mouse | LD50 | parenteral | 1950mg/kg (1950mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 328, 1940. | |
mouse | LD50 | subcutaneous | 1434mg/kg (1434mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 71, Pg. 138, 1941. | |
rat | LDLo | intraperitoneal | 750mg/kg (750mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 45, Pg. 15, 1940. |