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Cas Database |
| Name |
TETRAHYDRO-1,4-OXAZINYLMETHYLCODEINE |
EINECS | N/A |
| CAS No. | 509-67-1 | Density | 1.34g/cm3 |
| PSA | 54.40000 | LogP | 1.07930 |
| Solubility | N/A | Melting Point |
91°C |
| Formula | C23H30 N2 O4 | Boiling Point | 577.8°Cat760mmHg |
| Molecular Weight | 398.502 | Flash Point | 303.2°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx. Used as an antitussive agent. See also CODEINE. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Morphinan-6a-ol, 7,8-didehydro-4,5a-epoxy-17-methyl-3-(2-morpholinoethoxy)-(8CI); Morphine, 3-O-(2-morpholinoethyl)- (7CI); Morphine,O3-(2-morpholinoethyl)- (6CI); 3-[2-(4-Morpholinyl)ethyl]morphine; Biocalyptol;Codylin; Ethnine; Folcodin; Folcodine; Galenphol; Galphol; Glycodine; Hibernyl;Homocodeine; Memine; Morpholinylethylmorphine; Neocodine;O-2-Morpholinoethylmorphine; O3-(2-Morpholinoethyl)morphine; Pectolin;Pholcodine; Pholtex; Tussokon; Weifacodine; b-Morpholinylethylmorphine |
Article Data | 3 |
TETRAHYDRO-1,4-OXAZINYLMETHYLCODEINE Chemical Properties
Product Name: Pholcodine
Synonyms: (5Alpha,6Alpha)-7,8-Didehydro-4,5-epoxy-17-methyl-3-[2-(4-morpholinyl)ethoxy]morphinan-6-ol ; 3-(2-(4-morpholinyl)ethyl)Morphine ; 3-(2-morpholinoethyl)Morphine ; 3-Morpholylaethylmorphin ; 3-O-(2-morpholinoethyl)-Morphin ; 7,8-Didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-al ; 7,8-Didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-alpha-ol ; Beta-morpholinoethylmorphine
CAS: 509-67-1
Molecular Formula: C23H30N2O4
Molecular Weight:398.5
Molecular Struture: 
EINECS: 208-102-9
Mol File: 509-67-1.mol
Surface Tension: 63.4 dyne/cm
Density: 1.34 g/cm3
Flash Point: 303.2 °C
Enthalpy of Vaporization: 90.97 kJ/mol
Boiling Point: 577.8 °C at 760 mmHg
Vapour Pressure: 3.44E-14 mmHg at 25°C
Index of Refraction: 1.659
Appearance: Tetrahydro-1,4-oxazinylmethylcodeine (509-67-1) is white or almost white, crystalline powder
TETRAHYDRO-1,4-OXAZINYLMETHYLCODEINE Uses
Tetrahydro-1,4-oxazinylmethylcodeine (509-67-1) is used for severe dry cough and moderate degree of pain. Newborn and child are easy to tolerate the drug, without causing constipation and digestive disorders.
TETRAHYDRO-1,4-OXAZINYLMETHYLCODEINE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 400mg/kg (400mg/kg) | Therapie. Vol. 7, Pg. 21, 1952. | |
| mouse | LD50 | intravenous | 230mg/kg (230mg/kg) | Therapie. Vol. 7, Pg. 21, 1952. | |
| mouse | LD50 | oral | 1gm/kg (1000mg/kg) | Cesko-Slovenska Farmacie. Vol. 12, Pg. 89, 1963. | |
| mouse | LD50 | subcutaneous | 540mg/kg (540mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 325, 1958. |
| rabbit | LD50 | intravenous | 300mg/kg (300mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 325, 1958. |
TETRAHYDRO-1,4-OXAZINYLMETHYLCODEINE Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx. Used as an antitussive agent. See also CODEINE.
TETRAHYDRO-1,4-OXAZINYLMETHYLCODEINE Specification
1.Properties: Tetrahydro-1,4-oxazinylmethylcodeine (509-67-1) is odorless, bitter taste; aqueous react alkaline . soluble in acetone or chloroform,, soluble in water and ether, dissolved in dilute hydrochloric acid.
2.Pharmacological effects: This product has a central antitussive effect similar to codeine phosphate, but also has sedative and analgesic effect, but it's addictive is weaker than codeine phosphate.
3.Consumption usage:Oral: 1 5 ~ 15mg, 1 3 times a day. Maximum dose: 60mg / d.
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