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TIAPRIDE HYDROCHLORIDE

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Name

TIAPRIDE HYDROCHLORIDE

EINECS 256-908-4
CAS No. 51012-33-0 Density 1.15 g/cm3
PSA 84.09000 LogP 3.44400
Solubility N/A Melting Point approximate 200℃ (dec.)
Formula C15H24 N2 O4 S . Cl H Boiling Point 498.1 °C at 760 mmHg
Molecular Weight 364.894 Flash Point 255.1 °C
Transport Information N/A Appearance N/A
Safety Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx, NOx, and HCl. Risk Codes N/A
Molecular Structure Molecular Structure of 51012-33-0 (Tiapride hydrochloride) Hazard Symbols N/A
Synonyms

Benzamide,N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)-, monohydrochloride(9CI); Gramalil; Italprid; Luxoben; Sereprile; Tiapridal; Tiapridehydrochloride; Tiapridex

 

TIAPRIDE HYDROCHLORIDE Chemical Properties

UPAC Name: N-(2-diethylaminoethyl)-2-methoxy-5-methylsulfonylbenzamide hydrochloride (51012-33-0)
SynonymsTtiapride hydrochloride ; N-[2-(diethylamino)ethyl]-5-[methyl-sulfonyl]-o-anisamide hydrochloride ; N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)benzamidehydrochloride ; N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)-benzamidmonohydroch ; N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)-benzamidmonohydrochloride ; N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulphonyl)benzamide monohydrochloride ; TiapridHCl;Tiapridhydrochlorid
CAS: 51012-33-0
MF: C15H25ClN2O4S
MW: 364.89
MS:
EINECS: 256-908-4
Mol File: 51012-33-0.mol
Flash Point: 255.1 °C 
Enthalpy of Vaporization: 76.63 kJ/mol 
Boiling Point: 498.1 °C at 760 mmHg 
Vapour Pressure: 4.65E-10 mmHg at 25°C 
Storage temp:  StoreTiapride hydrochloride (51012-33-0)  at 2-8°C.

TIAPRIDE HYDROCHLORIDE Uses

Tiapride hydrochloride (51012-33-0)is antipsychotics.

TIAPRIDE HYDROCHLORIDE Production

Tiapride hydrochloride (51012-33-0)is prepared by reacting 2-methoxy-5-methylsulfonylbenzoic acid (I) with isobutyl chloroformate (A) in dioxane to give the corresponding anhydride (II), which is finally condensed with N,N-diethylethylenediamine (B).
 

TIAPRIDE HYDROCHLORIDE Toxicity Data With Reference

Organism

Test Type

Route

Reported Dose (Normalized Dose)

Effect

Source

dog

LD50

oral

240mg/kg (240mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
sense organs and special senses: ptosis: eye
behavioral: somnolence (general depressed activity)

Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.

mouse

LD50

intraperitoneal

336mg/kg (336mg/kg)

behavioral: altered sleep time (including change in righting reflex)
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold

Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.

mouse

LD50

intravenous

189mg/kg (189mg/kg)

behavioral: altered sleep time (including change in righting reflex)
behavioral: convulsions or effect on seizure threshold
behavioral: somnolence (general depressed activity)

Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.

mouse

LD50

oral

1340mg/kg (1340mg/kg)

behavioral: altered sleep time (including change in righting reflex)
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold

Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.

mouse

LD50

subcutaneous

755mg/kg (755mg/kg)

behavioral: altered sleep time (including change in righting reflex)
behavioral: convulsions or effect on seizure threshold
ehavioral: somnolence (general depressed activity)

Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.

rat

LD50

intraperitoneal

421mg/kg (421mg/kg)

sense organs and special senses: ptosis: eye
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold

Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.

rat

LD50

intravenous

254mg/kg (254mg/kg)

sense organs and special senses: ptosis: eye
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold

Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.

rat

LD50

oral

4840mg/kg (4840mg/kg)

sense organs and special senses: ptosis: eye
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold

Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.

rat

LD50

subcutaneous

1130mg/kg (1130mg/kg)

sense organs and special senses: ptosis: eye
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold

Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.

TIAPRIDE HYDROCHLORIDE Safety Profile

WGK Germany:  2
RTECS:  CV4203800

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