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Tetracycline hydrochloride

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Tetracycline hydrochloride

EINECS 200-593-8
CAS No. 64-75-5 Density
Solubility 50 g/L in water Melting Point 220-223 °C(lit.)
Formula C22H24N2O8.HCl Boiling Point 799.4 °C at 760 mmHg
Molecular Weight 480.90 Flash Point 437.3 °C
Transport Information Appearance Yellow crystalline powder
Safety 26-36 Risk Codes 36/37/38-20/21/22
Molecular Structure Molecular Structure of 64-75-5 (2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-) Hazard Symbols IrritantXi, HarmfulXn

Neocycline B;Paltet;Panmycin hydrochloride;Partrex;Polyotic ointment;Purocyclina;Remicyclin;Riocyclin;Robitet;Subamycin;Supramycin;Tefilin;Tet-Cy;Tetrabakat;Tetrabid;Tetrabon;Tetrachel;Tetracompren;Tetracycline hydrochloride;Tetracyn;Tetralution;Tetrosol;Triphacyclin;Unicin;Vetquamycin 324;2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride (8CI);Achro;Achromycin hydrochloride;Ala-Tet;Ambracyn;Bristacycline;Cancycline-250;Criseociclina;Dumocyclin;Helvecyclin;Hostacycline;Medamycin;Tetracycline HCL;


Tetracycline hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Tetracycline hydrochloride Specification

The Tetracycline hydrochloride is an organic compound with the formula C22H24N2O8.HCl. The systematic name of this chemical is (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride (1:1). With the CAS registry number 64-75-5, it is also named as 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-, hydrochloride (1:1). The product's categories are Active Pharmaceutical Ingredients; Antibiotics for Research and Experimental Use; Biochemistry; Others (Antibiotics for Research and Experimental Use); Antibiotic Explorer; TA - TEAntibiotics; Tetracyclines Antibiotics; Bacteriostatic Antibiotics; Chemical Structure; L - ZAlphabetic; Principle; TetracyclinesMore...Close...; Antibacterial; Antibiotics; Interferes with Protein Synthesis Spectrum of Activity;L - ZAntibiotics; Mechanism of Action; Antibiotics T-ZAntibiotics; Antibiotics Antibiotics; Antibiotics Research Essentials; Antibiotics A to; Antibiotics by Application; Cell Culture; Chemical Structure Class; Core Bioreagents; Genetic Marker Selection Antibiotics; Reagents and Supplements; Tetracyclines; Research Essentials. Besides, it is a yellow crystalline powder, which is a broad-spectrum polyketide antibiotic produced by the streptomyces genus of actinobacteria.

Physical properties about Tetracycline hydrochloride are:
(1)# of Rule of 5 Violations: 2; (2)ACD/LogD (pH 5.5): -4; (3)ACD/LogD (pH 7.4): -4; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 10; (9)#H bond donors: 7; (10)#Freely Rotating Bonds: 7; (11)Polar Surface Area: 181.62 Å2; (12)Flash Point: 437.3 °C; (13)Enthalpy of Vaporization: 121.9 kJ/mol; (14)Boiling Point: 799.4 °C at 760 mmHg; (15)Vapour Pressure: 5.82E-27 mmHg at 25°C.

Safety information of Tetracycline hydrochloride:
When you are using this chemical, please be cautious about it as the following:It is harmful by inhalation, in contact with skin and if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.CN(C)[C@@H]2C(\O)=C(\C(N)=O)C(=O)[C@@]3(O)C(/O)=C4/C(=O)c1c(cccc1O)[C@@](C)(O)[C@H]4C[C@@H]23
(2)InChI: InChI=1/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
(4)Std. InChI: InChI=1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1

The toxicity data of Tetracycline hydrochloride is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 200mg/kg/7D-I (200mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE Clinical Pharmacy. Vol. 4, Pg. 455, 1985.
mouse LD50 intraperitoneal 368mg/kg (368mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 16, Pg. 33, 1964.
mouse LD50 intravenous 157mg/kg (157mg/kg)   Farmaco, Edizione Scientifica. Vol. 10, Pg. 197, 1955.
mouse LD50 oral 2759mg/kg (2759mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 16, Pg. 33, 1964.
mouse LD50 unreported 105mg/kg (105mg/kg)   "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks In New Drugs, Proceedings of the Symposium on Toxicological Testing for Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague, Czechoslovakia, Univerzita Karlova, 1979Vol. -, Pg. 55, 1979.
rabbit LDLo intrapleural 35mg/kg (35mg/kg) LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL)

Lung. Vol. 174, Pg. 373, 1996.
rat LD50 intraperitoneal 318mg/kg (318mg/kg)   Gendai no Rinsho. Vol. 2, Pg. 26, 1968.
rat LD50 intravenous 128mg/kg (128mg/kg)   Farmaco, Edizione Scientifica. Vol. 10, Pg. 197, 1955.
rat LD50 oral 6443mg/kg (6443mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 subcutaneous 700mg/kg (700mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Toxicology and Applied Pharmacology. Vol. 9, Pg. 445, 1966.

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