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Tetraethylene glycol

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Name

Tetraethylene glycol

EINECS 203-989-9
CAS No. 112-60-7 Density 1.125 g/cm3
PSA 68.15000 LogP -0.97920
Solubility Soluble in water Melting Point -5.6 °C(lit.)
Formula C8H18O5 Boiling Point 328 °C at 760 mmHg
Molecular Weight 194.228 Flash Point 176.7 °C
Transport Information N/A Appearance colorless to light yellowish liquid
Safety 24/25 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 112-60-7 (Bis[2-(2-hydroxyethoxy)ethyl] ether) Hazard Symbols N/A
Synonyms

Tetraethyleneglycol (6CI,7CI,8CI);1,11-Dihydroxy-3,6,9-trioxaundecane;2,2'-[Oxybis(2,1-ethanediyloxy)]bisethanol;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethanol;3,6,9-Trioxaundecane-1,11-diol;Bis[2-(2-hydroxyethoxy)ethyl] ether;Hi-Dry;NSC 1262;

Article Data 28

Tetraethylene glycol Synthetic route

107-21-1

ethylene glycol

111-44-4

3-oxa-1,5-dichloropentane

112-60-7

Tetraethylene glycol

Conditions
ConditionsYield
With sodium hydroxide In dimethyl sulfoxide at 90℃; for 9h;32%
With sodium
75-21-8

oxirane

107-21-1

ethylene glycol

112-60-7

Tetraethylene glycol

Conditions
ConditionsYield
at 210℃; under 36775.4 Torr;
75-21-8

oxirane

107-21-1

ethylene glycol

A

112-60-7

Tetraethylene glycol

B

111-46-6

diethylene glycol

C

112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Conditions
ConditionsYield
at 130 - 210℃; unter Druck, 1 Mol Aethylenoxyd;
75-21-8

oxirane

111-46-6

diethylene glycol

A

112-60-7

Tetraethylene glycol

B

4792-15-8

Pentaethylene glycol

C

112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

75-21-8

oxirane

112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

112-60-7

Tetraethylene glycol

Conditions
ConditionsYield
unter Druck;
75-21-8

oxirane

112-60-7

Tetraethylene glycol

Conditions
ConditionsYield
With acetic acid Verseifung das entstehenden Diacetat des Tetraaethylenglykols mit Baryt;
107-21-1

ethylene glycol

106-93-4

ethylene dibromide

112-60-7

Tetraethylene glycol

Conditions
ConditionsYield
at 115 - 120℃;
107-21-1

ethylene glycol

106-93-4

ethylene dibromide

A

112-60-7

Tetraethylene glycol

B

4792-15-8

Pentaethylene glycol

C

111-46-6

diethylene glycol

D

112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Conditions
ConditionsYield
at 115 - 120℃; Produkt5: Hexaaethylenglykol;
111-44-4

3-oxa-1,5-dichloropentane

112-60-7

Tetraethylene glycol

Conditions
ConditionsYield
at 65℃;
68375-97-3

2-methyl-14-crown-5

A

112-60-7

Tetraethylene glycol

B

75-07-0

acetaldehyde

Conditions
ConditionsYield
With water; hydrogenchloride In 1,4-dioxane Rate constant; Equilibrium constant; Ambient temperature; effect of alkali and alkaline earth metal chlorides and concentrations of HCl;

Tetraethylene glycol Consensus Reports

Reported in EPA TSCA Inventory.

Tetraethylene glycol Specification

The Tetraethylene glycol, with the CAS registry number 112-60-7, is also known as Bis[2-(2-hydroxyethoxy)ethyl] ether. It belongs to the product categories of Ethylene Glycols; Ethylene Glycols & Monofunctional Ethylene Glycols. Its EINECS registry number is 203-989-9. This chemical's molecular formula is C8H18O5 and molecular weight is 194.23. Its IUPAC name is called 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol. This chemical's classification codes are Mutation data; Skin / Eye Irritant. It is colorless to straw-colored liquid. In addition, it should be stored in a cool, ventilated warehouse and kept away from fire and heat.

Physical properties of Tetraethylene glycol: (1)ACD/LogP: -2.23; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.23; (4)ACD/LogD (pH 7.4): -2.23; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.46; (8)ACD/KOC (pH 7.4): 1.46; (9)#H bond acceptors: 5; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 12; (12)Index of Refraction: 1.455; (13)Molar Refractivity: 47.41 cm3; (14)Molar Volume: 174.6 cm3; (15)Surface Tension: 41.3 dyne/cm; (16)Density: 1.111 g/cm3; (17)Flash Point: 176.7 °C; (18)Enthalpy of Vaporization: 66.1 kJ/mol; (19)Boiling Point: 328 °C at 760 mmHg; (20)Vapour Pressure: 1.47E-05 mmHg at 25°C.

Uses of Tetraethylene glycol: it can be used in organic synthesis as a solvent, hot carrier and gas chromatography stationary phase. Besides, it can be used with drying solvents, moisturizing agents, softening agents, nitro spray, etc.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. You should avoid contacting it with skin and eyes.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(COCCOCCOCCO)O
(2)InChI: InChI=1S/C8H18O5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h9-10H,1-8H2
(3)InChIKey: UWHCKJMYHZGTIT-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Union Carbide Data Sheet. Vol. 3, Pg. 3, 1969.
rat LD50 oral 28900uL/kg (28.9mL/kg)   Union Carbide Data Sheet. Vol. 3/3/1969,

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