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Tetramisole hydrochloride

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Name

Tetramisole hydrochloride

EINECS 225-799-5
CAS No. 5086-74-8 Density N/A
PSA 40.90000 LogP 2.32160
Solubility Water Solubility :200 g/L (20 °C) Melting Point 266-267 °C(lit.)
Formula C11H12N2S.HCl Boiling Point 344.4 °C at 760 mmHg
Molecular Weight 240.757 Flash Point 162.1 °C
Transport Information N/A Appearance white to pale cream crystalline powder
Safety 26-36 Risk Codes 22-36/37/38-20/21/22
Molecular Structure Molecular Structure of 5086-74-8 (Tetramisole hydrochloride) Hazard Symbols IrritantXi,HarmfulXn
Synonyms

Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride (9CI);Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (?à)- (8CI);2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride;Anthelvet;Citarin;Concurat;Curaminth;DL-Tetramisole hydrochloride;McN JR8299;NSC 170985;NSC 215179;Nilverm;Nilverom;R 8299;Ripercol;Verminject;

Article Data 7

Tetramisole hydrochloride Synthetic route

phosphorous pentasulfide

phosphorous pentasulfide

7440-44-0

pyrographite

65329-73-9

1-(2-acetoxy-ethyl)-4-phenyl-imidazolidin-2-one

5086-74-8

tetramisole hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In ethanol; chloroform; toluene
With hydrogenchloride; sodium hydroxide In ethanol; chloroform; toluene
phosphorous pentasulfide

phosphorous pentasulfide

65329-69-3

1-(2-methoxy-ethyl)-4-phenyl-imidazolidin-2-one

5086-74-8

tetramisole hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In ethanol; chloroform; toluene
phosphorous pentasulfide

phosphorous pentasulfide

65329-72-8

1-(2-hydroxy-ethyl)-4-phenyl-imidazolidin-2-one

5086-74-8

tetramisole hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In ethanol; chloroform; toluene
With hydrogenchloride; sodium hydroxide In ethanol; chloroform; toluene
65329-70-6

1-(2-methoxy-ethyl)-4-phenyl-imidazolidine-2-thione

5086-74-8

tetramisole hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; acetone
With hydrogenchloride In ethanol; acetone
65329-69-3

1-(2-methoxy-ethyl)-4-phenyl-imidazolidin-2-one

5086-74-8

tetramisole hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; diphosphorus pentasulfide; sodium hydroxide In ethanol; chloroform; toluene
Multi-step reaction with 2 steps
1: hydrogenchloride; sodium hydroxide / chloroform; acetone; toluene
2: hydrogenchloride / ethanol; acetone
View Scheme
69510-65-2

1-(2-hydroxy-ethyl)-4-phenyl-imidazolidine-2-thione

5086-74-8

tetramisole hydrochloride

Conditions
ConditionsYield
In hydrogenchloride; isopropyl alcohol
70-11-1

α-bromoacetophenone

5086-74-8

tetramisole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid / methanol; dichloromethane; chloroform; water
2: palladium / ethanol; hydrogen
3: hydrogenchloride; diphosphorus pentasulfide; sodium hydroxide / ethanol; chloroform; toluene
View Scheme
Multi-step reaction with 4 steps
1: acetic acid / methanol; dichloromethane; chloroform; water
2: palladium / ethanol; hydrogen
3: hydrogenchloride; sodium hydroxide / chloroform; acetone; toluene
4: hydrogenchloride / ethanol; acetone
View Scheme
65346-98-7

1-(2-methoxy-ethyl)-4-phenyl-1,3-dihydro-imidazol-2-one

5086-74-8

tetramisole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium / ethanol; hydrogen
2: hydrogenchloride; diphosphorus pentasulfide; sodium hydroxide / ethanol; chloroform; toluene
View Scheme
Multi-step reaction with 3 steps
1: palladium / ethanol; hydrogen
2: hydrogenchloride; sodium hydroxide / chloroform; acetone; toluene
3: hydrogenchloride / ethanol; acetone
View Scheme
5086-74-8

tetramisole hydrochloride

5036-02-2

Tetramisole

Conditions
ConditionsYield
With sodium hydroxide In diethyl ether; water at 20℃; for 0.5h; Inert atmosphere;95%
15243-33-1

dodecacarbonyl-triangulo-triruthenium

5086-74-8

tetramisole hydrochloride

[Ru3(μ-Cl)(μ-.eta(2)-levamisole-C,S)(CO)9]

Conditions
ConditionsYield
In tetrahydrofuran all manipulations under N2; mixt. of Ru and org. compds. in THF stirred and refluxed for 40 min; cooled to room temp., filtered, filtrate concd., pptd. with hexane, elem. anal.;93%

Tetramisole hydrochloride Chemical Properties

IUPAC Name: 6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride
Product Category of Tetramisole hydrochloride (CAS NO.5086-74-8): API;Veterinaries
Molecular Formula: C11H13ClN2S
Molecular Weight: 240.75 g/mol
EINECS: 225-799-5
Flash Point: 162.1 °C 
Melting point:  266-267 °C(lit.)
Water Solubility: 200 g/L (20 °C)
Enthalpy of Vaporization: 58.83 kJ/mol 
Boiling Point: 344.4 °C at 760 mmHg
Vapour Pressure: 6.61E-05 mmHg at 25 °C 
Appearance: White to pale cream crystalline powder
Structure of Tetramisole hydrochloride  (CAS NO.5086-74-8):
                       

Tetramisole hydrochloride Uses

 Tetramisole hydrochloride  (CAS NO.5086-74-8) can be used as intermediate of levamisole and anti-worm drugs.

Tetramisole hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
duck LD50 oral 958mg/kg (958mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Veterinariya. Veterinary Science. Vol. 54(5), Pg. 64, 1978.
human TDLo oral 2mg/kg (2mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Toxicology and Applied Pharmacology. Vol. 20, Pg. 602, 1971.
mouse LD50 intravenous 22mg/kg (22mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Nature. Vol. 209, Pg. 1084, 1966.
mouse LD50 oral 210mg/kg (210mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Nature. Vol. 209, Pg. 1084, 1966.
mouse LD50 subcutaneous 84mg/kg (84mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Nature. Vol. 209, Pg. 1084, 1966.
rat LD50 intravenous 24mg/kg (24mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Nature. Vol. 209, Pg. 1084, 1966.
rat LD50 oral 480mg/kg (480mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Nature. Vol. 209, Pg. 1084, 1966.
rat LD50 subcutaneous 130mg/kg (130mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Nature. Vol. 209, Pg. 1084, 1966.

  Tetramisole hydrochloride (CAS NO.5086-74-8) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.

Tetramisole hydrochloride Safety Profile

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-20/21/22
20/21/22: Tetramisole hydrochloride (5086-74-8) is harmful by inhalation, in contact with skin and if swallowed
36/37/38:  Irritating to eyes, respiratory system and skin
Safety Statements:  26-36
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing
WGK Germany:  3
RTECS:  NJ5950000

Tetramisole hydrochloride Specification

 Tetramisole hydrochloride , its cas register number is 5086-74-8. It also can be called Levamisole hydrochloride ; DL-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride ; and Nilverm . It is stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Its hazardous polymerization will not occur. In addition, it should be stored in a cool, dry place.
 It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water, and get medical aid immediately. In addition, Tetramisole hydrochloride  (CAS NO.5086-74-8) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.

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