Irwin A. Rose (born July 16, 1926) is an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.

Rose attended Washington State University for one year prior to serving in the Navy during WWII. Upon returning from the war he received his B.S. in 1948 and his Ph.D. in biochemistry in 1952, both from the University of Chicago.
He joined Fox Chase Cancer Center's division of basic in 1963 and stayed there until he retired in 1995.