Paul Delos Boyer (born July 31, 1918) is an American biochemist and analytical chemist. He shared the 1997 Nobel Prize in Chemistry for research on the "enzymatic mechanism underlying the biosynthesis of adenosine triphosphate (ATP)" (ATP synthase) with John E. Walker; the remainder of the Prize in that year was awarded to Danish chemist Jens Christian Skou for his discovery of the Na+/K+-ATPase.

He received a B.S. in chemistry from Brigham Young University in 1939 and obtained a Wisconsin Alumni Research Foundation Scholarship for graduate studies.
After Boyer received his Ph.D. degree in biochemistry from the University of Wisconsin–Madison in 1943, he spent years at Stanford University on a war-related research project dedicated to stabilization of serum albumin for transfusions.
In 1955, he received a Guggenheim Fellowship and worked with Professor Hugo Theorell on the mechanism of alcohol dehydrogenase.
In 1956, he accepted a Hill Foundation Professorship and moved to the medical campus of the University of Minnesota.
In 1959-1960, he served as Chairman of the Biochemistry Section of the American Chemical Society (ACS) and in 1969-1970 as President of the American Society of Biological Chemists.
In 1981, he was Faculty Research Lecturer at UCLA. In that same year, he was awarded the prestigious Tolman Medal by the Southern California Section of the American Chemical Society.