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Cas Database |
| Name |
Thiazole-2-carboxylic acid |
EINECS | N/A |
| CAS No. | 14190-59-1 | Density | 1.525 g/cm3 |
| PSA | 78.43000 | LogP | 0.84130 |
| Solubility | Slightly soluble in water. | Melting Point |
91.6-93 °C |
| Formula | C4H3NO2S | Boiling Point | 310.6 °C at 760 mmHg |
| Molecular Weight | 129.139 | Flash Point | 141.6 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | 26-36/37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols | R36/37/38:; |
| Synonyms |
1,3-Thiazole-2-carboxylicacid;2-Carboxythiazole;2-Thiazolecarboxylic acid,thiazole-2-carboxylic acid; |
Article Data | 24 |
Thiazole-2-carboxylic acid Synthetic route
| Conditions | Yield |
|---|---|
| Stage #1: 2-bromo-1,3-thiazole With n-butyllithium In tetrahydrofuran Stage #2: carbon dioxide | 73% |
| Stage #1: 2-bromo-1,3-thiazole With n-butyllithium In diethyl ether; hexane at -78℃; for 0.166667h; Stage #2: carbon dioxide In diethyl ether; hexane at -78℃; for 1.16667h; | 64% |
- 288-47-1
1,3-thiazole
- 124-38-9
carbon dioxide
A
- 14527-41-4
thiazole-5-carboxylic acid
B
- 14190-59-1
1,3-thiazole-2-carboxylic acid
| Conditions | Yield |
|---|---|
| Stage #1: carbon dioxide With AuOH(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene); potassium hydroxide In tetrahydrofuran at 20℃; under 1125.11 Torr; for 0.25h; Stage #2: 1,3-thiazole In tetrahydrofuran at 20℃; under 1125.11 Torr; for 12h; Stage #3: With hydrogenchloride In tetrahydrofuran; water regioselective reaction; | A 27% B 61% |
| Conditions | Yield |
|---|---|
| With n-butyllithium; carbon dioxide | A 57% B n/a |
- 14527-42-5
thiazole-2-carboxylic acid ethyl ester
- 14190-59-1
1,3-thiazole-2-carboxylic acid
| Conditions | Yield |
|---|---|
| Stage #1: thiazole-2-carboxylic acid ethyl ester With potassium hydroxide; ethanol; water at 20℃; for 2h; Stage #2: With hydrogenchloride; water In ethanol | 25% |
| With potassium hydroxide | |
| Stage #1: thiazole-2-carboxylic acid ethyl ester With potassium hydroxide; ethanol at 120℃; for 0.5h; Stage #2: With hydrogenchloride; water In ethanol pH=4.0; | |
| Stage #1: thiazole-2-carboxylic acid ethyl ester With potassium hydroxide; ethanol at 120℃; for 0.5h; Stage #2: With hydrogenchloride In ethanol; water pH=4.0; | |
| Stage #1: thiazole-2-carboxylic acid ethyl ester With potassium hydroxide; ethanol; water at 20℃; for 2h; Stage #2: With hydrogenchloride; water |
- 288-47-1
1,3-thiazole
- 14190-59-1
1,3-thiazole-2-carboxylic acid
| Conditions | Yield |
|---|---|
| With diethyl ether; phenyllithium anschliessend Behandeln mit CO2; |
- 3034-53-5
2-bromo-1,3-thiazole
- 14190-59-1
1,3-thiazole-2-carboxylic acid
| Conditions | Yield |
|---|---|
| With n-butyllithium; diethyl ether anschliessend mit CO2; |
- 115-08-2
thiocarboxamide
- 14190-59-1
1,3-thiazole-2-carboxylic acid
| Conditions | Yield |
|---|---|
| beim anschliessenden Verseifen; reagirt analog mit 2-Chlor-acetessigsaeure-aethylester, 3-Chlor-laevulinsaeure-aethylester,; |
- 1192365-76-6
C4H2NO2S(1-)*Li(1+)
- 14190-59-1
1,3-thiazole-2-carboxylic acid
| Conditions | Yield |
|---|---|
| With sulfuric acid; water |
| Conditions | Yield |
|---|---|
| Stage #1: 1,3-thiazole With n-butyllithium In tetrahydrofuran at -60℃; for 0.166667h; Stage #2: carbon dioxide In tetrahydrofuran | |
| Stage #1: 1,3-thiazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78 - 20℃; for 2h; Inert atmosphere; | 12 g |
- 14190-59-1
1,3-thiazole-2-carboxylic acid
- 115012-25-4
6-aminohexanoic acid phenylamide
| Conditions | Yield |
|---|---|
| With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; | 94% |
Thiazole-2-carboxylic acid Chemical Properties
IUPAC Name: 1,3-Thiazole-2-carboxylic acid
Synonyms of Thiazole-2-carboxylic acid (CAS NO.14190-59-1): 1,3-Thiazole-2-carboxylic acid ; 2-Thiazolecarboxylic acid,thiazole-2-carboxylic acid
CAS NO: 14190-59-1
Molecular Formula: C4H3NO2S
Molecular Weight: 129.1371
Molecular Structure:
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Melting Point: 91.6-93°C
ProductCategories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts ; Thiazole series ; Carboxylic Acids ; Thiazoles, Isothiazoles &Benzothiazoles ; Carboxylic Acids ; Thiazoles, Isothiazoles & Benzothiazoles
Polar Surface Area: 67.43 Å2
Index of Refraction: 1.617
Molar Refractivity: 29.65 cm3
Molar Volume: 84.6 cm3
Surface Tension: 72 dyne/cm
Density of Thiazole-2-carboxylic acid (CAS NO.14190-59-1): 1.525 g/cm3
Flash Point: 141.6 °C
Enthalpy of Vaporization: 58.22 kJ/mol
Boiling Point: 310.6 °C at 760 mmHg
Vapour Pressure: 0.000256 mmHg at 25°C
Thiazole-2-carboxylic acid Safety Profile
Risk Statements of Thiazole-2-carboxylic acid (CAS NO.14190-59-1): 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
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