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Tilorone dihydrochloride

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Name

Tilorone dihydrochloride

EINECS N/A
CAS No. 27591-69-1 Density 1.102g/cm3
PSA 42.01000 LogP 5.94320
Solubility N/A Melting Point 230-233 °C
Formula C25H36Cl2N2O3 Boiling Point 552.3 °C at 760 mmHg
Molecular Weight 483.478 Flash Point 287.8 °C
Transport Information N/A Appearance orange yellow crystal powder
Safety 7-22-26-37/39 Risk Codes 20/21/22-36/37/38-40
Molecular Structure Molecular Structure of 27591-69-1 (Tilorone dihydrochloride) Hazard Symbols HarmfulXn
Synonyms

9H-Fluoren-9-one,2,7-bis[2-(diethylamino)ethoxy]-, dihydrochloride (9CI);Fluoren-9-one,2,7-bis[2-(diethylamino)ethoxy]-, dihydrochloride (8CI);Amixinum;Amyxin;DEAE-F;RMI 10008DA;RMI 10028DA;Tilorone hydrochloride;

Article Data 4

Tilorone dihydrochloride Chemical Properties

Molecular Structure of Tilorone dihydrochloride (CAS NO.27591-69-1):

IUPAC Name: 2,7-bis(2-diethylaminoethyloxy)fluoren-9-one dihydrochloride 
Empirical Formula: C25H36Cl2N2O3
Molecular Weight: 483.4709
H bond acceptors: 5
H bond donors: 0
Freely Rotating Bonds: 12
Polar Surface Area: 42.01Å2
Melting Point: 230-233 °C
Merck: 13,9517
Flash Point: 287.8 °C
Enthalpy of Vaporization: 83.28 kJ/mol
Boiling Point: 552.3 °C at 760 mmHg
Vapour Pressure: 3.05E-12 mmHg at 25°C
InChI
InChI=1/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H
Smiles
c12c3ccc(cc3C(c1cc(OCCN(CC)CC)cc2)=O)OCCN(CC)CC.Cl.Cl
Product Categories: Fluorene series; Fused Ring Systems

Tilorone dihydrochloride Toxicity Data With Reference

1.    

dnd-esc 20 µmol/L

    MUREAV    Mutation Research. 89 (1981),95.
2.    

dni-mus:leu 14,600 µg/L

    INNDDK    Investigational New Drugs. The Journal of New Anticancer Agents. 1 (1983),103.
3.    

orl-hmn TDLo:4 mg/kg:CNS,GIT

    CCROBU    Cancer Chemotherapy Reports, Part 1. 57 (1973),209.
4.    

orl-rat LD50:852 mg/kg

    SCIEAS    Science. 169 (1970),1213.
5.    

ipr-rat LD50:244 mg/kg

    SCIEAS    Science. 169 (1970),1213.
6.    

orl-mus LD50:959 mg/kg

    SCIEAS    Science. 169 (1970),1213.
7.    

ipr-mus LD50:145 mg/kg

    SCIEAS    Science. 169 (1970),1213.

Tilorone dihydrochloride Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. Human systemic effects by ingestion: somnolence, anorexia, hypermotility and diarrhea. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.Safety information of Tilorone dihydrochloride (CAS NO.27591-69-1):
Hazard Codes:  HarmfulXn
Risk Statements:
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
40: Limited evidence of a carcinogenic effect
Safety Statements:
7: Keep container tightly closed
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
RTECS: LL9000000

Tilorone dihydrochloride Specification

  Tilorone dihydrochloride , with CAS number of 27591-69-1, can be called 9H-Fluoren-9-one,2,7-bis[2-(diethylamino)ethoxy]-, dihydrochloride (9CI) ; Fluoren-9-one,2,7-bis[2-(diethylamino)ethoxy]-, dihydrochloride (8CI) ; Tilorone hydrochloride .

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