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Topotecan hydrochloride

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Name

Topotecan hydrochloride

EINECS 601-607-9
CAS No. 119413-54-6 Density 1.49 g/cm3
PSA 104.89000 LogP 2.64880
Solubility N/A Melting Point 213-218 °C
Formula C23H23N3O5.HCl Boiling Point 782.9 °C at 760 mmHg
Molecular Weight 457.914 Flash Point 427.3 °C
Transport Information N/A Appearance White Crystalline Solid
Safety 26-36/37/39-45 Risk Codes 25-36/37/38-46
Molecular Structure Molecular Structure of 119413-54-6 (Topotecan hydrochloride) Hazard Symbols ToxicT
Synonyms

Topotecan HCl;Hycamtin;NSC 609669;Nogitecan hydrochloride;SKF 104864A;SKFS 104864A;

Article Data 10

Topotecan hydrochloride Chemical Properties

The Molecular formula of  Topotecan HCl (119413-54-6): C23H24ClN3O5
The Molecular Weight of  Topotecan HCl (119413-54-6): 457.91
Molecular Structure : 
Melting point:  213-218 °C 
Index of Refraction: 1.733
Surface Tension: 82.8 dyne/cm
Density: 1.49 g/cm3
Flash Point: 427.3 °C
Enthalpy of Vaporization: 119.49 kJ/mol
Boiling Point: 782.9 °C at 760 mmHg
Vapour Pressure: 8.13E-26 mmHg at 25 °C 
Appearance of Topotecan HCl (119413-54-6): White Crystalline Solid

 

Topotecan hydrochloride Uses

 Topotecan HCl (119413-54-6) is naturally occurring amino acid.It is the precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme.And it is antineoplastic (photosensitizer),especially a DNA topoisomerase I inhibitor,just like semisynthetic analog of Camptothecin.

Topotecan hydrochloride Safety Profile

The Hazard Codes of  Topotecan HCl (119413-54-6) :  T
The Risk Statements information of  Topotecan HCl (119413-54-6): 25-36/37/38-46
25:  Toxic if swallowed 
46:  May cause heritable genetic damage
36/37/38:  Irritating to eyes, respiratory system and skin
The Safety Statements information of  Topotecan HCl (119413-54-6): 26-36/37/39-45
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice    
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection 

Topotecan hydrochloride Specification

 Topotecan HCl (119413-54-6),also called topotecan monohydrochloride;topetecan hydrochloride;5-piperazin-1-yl-benzofuran-2-carboxylic acid ethyl ester,is white crystalline solid.

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