- Tosyl azide
- Tosyl chloride
- Tosyl cyanide
- Tosyl isocyanate
- Tosyl-L-Asparagine
- Tosyl-l-phenylalanylchloromethyl ketone
- Tosylmethyl isocyanide
- Tosylphenylalanyl chloromethyl ketone
- 408367-99-7[1,1'-Biphenyl]-2-carboxylicacid, 3'-(trifluoromethyl)-
- 40836-94-02-methyl-sulphanyl-4,5-dihydrothiazoline hydroiodide
- 4084-27-9D-erythro-Hexos-2-ulose,3-deoxy-
- 40843-25-2Propanoic acid,2-[4-(2,4-dichlorophenoxy)phenoxy]-
- 40843-28-5Propanoic acid,2-[4-(4-methylphenoxy)phenoxy]-
- 40843-35-4Propanoic acid,2-[4-(2-chlorophenoxy)phenoxy]-
- 40843-52-5Phenol,4-(4-chloro-3-methylphenoxy)-
- 40843-73-0Phenol,4-(2,4-dichlorophenoxy)-
- 4084-38-2Benzenemethanol,2,3,5,6-tetrafluoro-
- 40846-66-0Butanoic acid,2-isocyano-3-methyl-, methyl ester
Hot Products
- 4090-51-12,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide
- 40910-49-41-ETHOXY-1-(3,7-DIMETHYL-1,6-OCTADIEN-3-YLOXY)ETHANE
- 4091-39-83-Chloro-2-butanone
- 409325-06-02-Propenoic acid, (3-phenoxyphenyl)methyl ester
- 409353-44-24-(3-Formyl-2,5-dimethyl-pyrrol-1-yl)-3-methyl-benzoic acid
- 40963-98-2ethyl 5-methoxy-1,2-dimethylindole-3-carboxylate
- 4096-48-4N-(carboxycarbonyl)-L-homoserine
- 4096-72-42,6-di-tert-butyl-4-chlorophenol
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
Tosyl isocyanate |
EINECS | 223-810-8 |
| CAS No. | 4083-64-1 | Density | 1.27 g/cm3 |
| PSA | 71.95000 | LogP | 2.10030 |
| Solubility | reacts with water | Melting Point |
5°C |
| Formula | C8H7NO3S | Boiling Point | 288.8 °C at 760 mmHg |
| Molecular Weight | 197.214 | Flash Point | 128.5 °C |
| Transport Information | UN 2206 6.1/PG 3 | Appearance | clear liquid |
| Safety | 26-28-30-28A | Risk Codes | 14-36/37/38-42 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
p-Toluenesulfonic acid,anhydride with isocyanic acid (7CI,8CI);4-Methylbenzenesulfonyl isocyanate;4-Methylphenylsulfonyl isocyanate;4-Toluenesulfonyl isocyanate;Additive TI;PTSI;p-Toluene sulphonyl isocyanate;p-Methylbenzenesulfonyl isocyanate;p-Methylphenylsulfonyl isocyanate;p-Toluenesulfonyl isocyanate;p-Tosyl isocyanate; |
Article Data | 28 |
Tosyl isocyanate Synthetic route
- 4083-64-1
Tosyl isocyanate
| Conditions | Yield |
|---|---|
| In toluene at 140℃; for 2h; Glovebox; | 84% |
- 941-55-9
4-toluenesulfonyl azide
- 201230-82-2
carbon monoxide
A
- 4083-64-1
Tosyl isocyanate
B
- 70-55-3
toluene-4-sulfonamide
| Conditions | Yield |
|---|---|
| With palladium diacetate In acetonitrile at 40℃; for 4h; Schlenk technique; | A 25% B 75% |
| Stage #1: 4-toluenesulfonyl azide; carbon monoxide With palladium diacetate In acetonitrile at 80℃; for 4h; Stage #2: With water | A 23 %Chromat. B 77 %Chromat. |
- 201230-82-2
carbon monoxide
- 55962-05-5
[N-(p-tolylsulfonyl)imino]phenyliodinane
- 4083-64-1
Tosyl isocyanate
| Conditions | Yield |
|---|---|
| bis(benzonitrile)palladium(II) dichloride In dichloromethane; acetonitrile under 28502.3 Torr; for 0.666667h; Ambient temperature; | 60% |
| Conditions | Yield |
|---|---|
| With 1,2,3-trichlorobenzene | |
| In 5,5-dimethyl-1,3-cyclohexadiene at 100℃; for 2h; Time; Temperature; Solvent; Inert atmosphere; |
- 101386-15-6
p-toluenesulphonyloxamoyl chloride
- 4083-64-1
Tosyl isocyanate
| Conditions | Yield |
|---|---|
| With 1,2-dichloro-benzene Heating; |
| Conditions | Yield |
|---|---|
| In dichloromethane at 20℃; for 15h; | |
| In dichloromethane at 20℃; for 10h; |
- 1189-71-5
isocyanate de chlorosulfonyle
- 70841-00-8
dibutyl di(p-methylphenyl)tin
- 4083-64-1
Tosyl isocyanate
| Conditions | Yield |
|---|---|
| at 40℃; for 10h; |
| Conditions | Yield |
|---|---|
| bis(benzonitrile)palladium(II) dichloride In dichloromethane; acetonitrile at 20℃; under 30002.4 Torr; Yield given; |
| Conditions | Yield |
|---|---|
| tris-(dibenzylideneacetone)dipalladium(0) In dichloromethane at 55℃; under 30002.4 Torr; Yield given; |
- 201230-82-2
carbon monoxide
- 52867-19-3
diphenyl-N-(p-toluenesulfonyl)selenimide
- 4083-64-1
Tosyl isocyanate
| Conditions | Yield |
|---|---|
| With bis(benzonitrile)palladium(II) dichloride; benzonitrile In dichloromethane under 26252.1 Torr; r.t., 30 min then 50 deg C, 2.5 h; |
Tosyl isocyanate Chemical Properties
IUPAC Name: 4-Methyl-N-(oxomethylidene)benzenesulfonamide
Synonyms of p-Toluene sulphonyl isocyanate (CAS NO.4083-64-1): EINECS 223-810-8 ; Benzenesulfonyl isocyanate, 4-methyl- ; p-Toluenesulphonyl isocyanate ; p-Toluenesulfonic acid, anhydride with isocyanic acid
CAS NO: 4083-64-1
Molecular Formula: C8H7NO3S
Molecular Weight: 197.2111
Molecular Structure:
.png)
Melting Point: 5°C
Product Categories: Benzene derivatives ; Benzene derivates ; Sulfur Compounds (for Synthesis) ; Synthetic Organic Chemistry
Polar Surface Area: 71.95 Å2
Index of Refraction: 1.566
Molar Refractivity: 50.33 cm3
Molar Volume: 154.2 cm3
Surface Tension: 48.7 dyne/cm
Density: 1.27 g/cm3
Flash Point: 128.5 °C
Enthalpy of Vaporization: 50.69 kJ/mol
Boiling Point: 288.8 °C at 760 mmHg
Vapour Pressure: 0.00396 mmHg at 25°C
Tosyl isocyanate Uses
p-Toluene sulphonyl isocyanate (CAS NO.4083-64-1) is used as a water scavenger in urethane products. End application include adhesives, coatings and sealants. It is also used as an intermediate in organic synthesis.
Tosyl isocyanate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LC50 | inhalation | > 640ppm/1H (640ppm) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | International Journal of Toxicology. Vol. 19, Pg. 368, 2000. |
| rat | LD50 | intraperitoneal | 775mg/kg (775mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | International Journal of Toxicology. Vol. 19, Pg. 368, 2000. |
| rat | LD50 | oral | 2234mg/kg (2234mg/kg) | GASTROINTESTINAL: OTHER CHANGES | International Journal of Toxicology. Vol. 19, Pg. 368, 2000. |
Tosyl isocyanate Safety Profile
The Hazard Codes of p-Toluene sulphonyl isocyanate (CAS NO.4083-64-1): 
Xn
The Risk Statements information:
14: Reacts violently with water
42: May cause sensitization by inhalation
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
30: Never add water to this product
RIDADR: UN 2206 6.1/PG 3
WGK Germany: 1
RTECS: DB9032000
F: 10
HazardClass: 6.1
PackingGroup: III
Moderately toxic by ingestion and intraperitoneal routes. Low toxicity by inhalation. A mild skin and moderate eye irritant. When heated to decomposition it emits toxic vapors of NOx and SOx.
Tosyl isocyanate Standards and Recommendations
APPEARANCE: clear liquid
Assay (GC): 98.0% min
SUM IMPURITY: 2.0% max
Tosyl isocyanate Specification
PACKING: 200kgs in drum
HAZARD CLASS: 6.1 (Packing Group: II)
UN NO.: 2206
What can I do for you?
Get Best Price
