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Tris(2-methyl-1-aziridinyl)phosphine oxide

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Name

Tris(2-methyl-1-aziridinyl)phosphine oxide

EINECS 200-326-5
CAS No. 57-39-6 Density 1.275 g/cm3
PSA 35.91000 LogP 1.02050
Solubility N/A Melting Point 25°C
Formula C9H18N3OP Boiling Point 311.678 °C at 760 mmHg
Molecular Weight 215.235 Flash Point 142.298 °C
Transport Information UN 2810 Appearance Water white to straw coloured viscous liquid
Safety Risk Codes R38
Molecular Structure Molecular Structure of 57-39-6 (Tris(2-methyl-1-aziridinyl)phosphine oxide) Hazard Symbols Xi
Synonyms

Phosphineoxide, tris(2-methyl-1-aziridinyl)- (6CI,8CI);EMT 50003;MAPO;MAPO(chemosterilant);Metapa;Metapoxide;Metepa;Methaphoxide;Methyl aphoxide;NSC 54054;Trimethylaziridinylphosphine oxide;Tris(1,2-propylene)phosphoramide;Tris(2-methylaziridinyl)phosphine oxide;Tris(methylaziridinyl)phosphine oxide;

Article Data 2

Tris(2-methyl-1-aziridinyl)phosphine oxide Chemical Properties

IUPAC Name: 1-Bis(2-methylaziridin-1-yl)phosphoryl-2-methylaziridine
The MF of 1-Bis(2-methylaziridin-1-yl)phosphoryl-2-methylaziridine (57-39-6) is C9H18N3OP.

                                           
The MW of 1-Bis(2-methylaziridin-1-yl)phosphoryl-2-methylaziridine (57-39-6) is 215.23.
Synonyms of 1-Bis(2-methylaziridin-1-yl)phosphoryl-2-methylaziridine (57-39-6): 1,1',1'-Phosphinylidynetris(2-methyl)azridine ; 1,1',1'-Phosphinylidynetris(2-methyl-aziridine ; 1,1',1'-Phosphinylidynetris[2-methyl-aziridin]
Appearance: White to straw colored liquid with a strong ammonia-like odor
Index of Refraction: 1.576 
EINECS: 200-326-5 
Density: 1.27 g/ml 
Flash Point: 142.3 °C
Boiling Point: 311.7 °C

Tris(2-methyl-1-aziridinyl)phosphine oxide Uses

  1-Bis(2-methylaziridin-1-yl)phosphoryl-2-methylaziridine (57-39-6) is used in the manufacture of composite solid propellant and the coated layer.

Tris(2-methyl-1-aziridinyl)phosphine oxide Toxicity Data With Reference

1.    

dni-esc 10 mmol/L

    IJEBA6    Indian Journal of Experimental Biology. 22 (1984),453.
2.    

cyt-hmn:lym 20 mg/L

    SOGEBZ    Soviet Genetics. Translation of GNKAA5. 8 (1972),783.
3.    

orl-rat LD50:136 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 14 (1969),515.
4.    

skn-rat LD50:183 mg/kg

    BWHOA6    Bulletin of the World Health Organization. 31 (1964),737.
5.    

orl-mus LD50:292 mg/kg

    INHEAO    Industrial Health. 8 (1970),54.
6.    

skn-mus LD50:375 mg/kg

    INHEAO    Industrial Health. 8 (1970),54.
7.    

ipr-mus LDLo:3125 µg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 23 (1972),288.
8.    

scu-mus LD50:140 mg/kg

    INHEAO    Industrial Health. 8 (1970),54.
9.    

orl-ckn LD50:329 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 16 (1970),100.
10.    

orl-dom LDLo:50 mg/kg

    ANYAA9    Annals of the New York Academy of Sciences. 111 (1964),715.

Tris(2-methyl-1-aziridinyl)phosphine oxide Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 ,1975,p. 107.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Tris(2-methyl-1-aziridinyl)phosphine oxide Safety Profile

Poison by ingestion, skin contact, intraperitoneal, and subcutaneous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic data. Animal experiments suggest cholinesterase inhibition, possibly due to metabolic products of this material in the body. When heated to decomposition it emits very toxic fumes of NOx and POx.
Safety information of 1-Bis(2-methylaziridin-1-yl)phosphoryl-2-methylaziridine (57-39-6):
RIDADR  2810
HazardClass  6.1(b)
PackingGroup  III

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