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Tris(hydroxymethyl)aminomethanehydrochloride
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Name

Tris(hydroxymethyl)aminomethanehydrochloride

 EINECS 214-684-5
CAS No. 1185-53-1 Density 1.05g/mLat 20°C
PSA 86.71000 LogP -0.83690
Solubility soluble in water Melting Point 150-152 ºC
Formula C4H12ClNO3 Boiling Point 357 ºC at 760 mmHg
Molecular Weight 157.597 Flash Point 169.7 ºC
Transport Information N/A Appearance White crystalline powder
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 1185-53-1 (2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride) Hazard Symbols IrritantXi
Synonyms

Tris(Hydroxymethyl)aminomethane hydrochloride [TRIS·HCL];Tris HCl;Tris-HCL;1,3-Propanediol,2-amino-2-(hydroxymethyl)-, hydrochloride (8CI,9CI);2-Amino-2-(hydroxymethyl)-1,3-propanediolhydrochloride;T 6666;Tri(hydroxymethyl)aminomethane hydrochloride;Trischloride;Tris(hydroxymethyl)aminomethane hydrochloride;Trizma hydrochloride;

Article Data 5

Tris(hydroxymethyl)aminomethanehydrochloride Synthetic route

cis-2,8-diphenyl-5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane

1185-53-1

tris hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol for 1h; Heating;80%
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

1185-53-1

tris hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 3h;
40018-26-6

1,4-dithiane-2,5-diol

1185-53-1

tris hydrochloride

2-(2,5-dithia-7-azabicyclo[2.2.1]heptan-7-yl)-2-(hydroxymethyl)propane-1,3-diol

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 3h; Reflux;97%
933-40-4

cycloxexanone dimethyl ketal

1185-53-1

tris hydrochloride

C10H19NO3

Conditions
ConditionsYield
Stage #1: cycloxexanone dimethyl ketal; tris hydrochloride With toluene-4-sulfonic acid In N,N-dimethyl-formamide for 17h;
Stage #2: With triethylamine In ethyl acetate		94%
1125-88-8

benzaldehyde dimethyl acetal

1185-53-1

tris hydrochloride

51430-74-1

5-amino-5-hydroxymethyl-2-phenyl-1,3-dioxane

Conditions
ConditionsYield
With toluene-4-sulfonic acid; triethylamine for 12h; Ambient temperature;90%

3H3N*3H(1+)*[CrMo6O18(OH)6](3-)

1185-53-1

tris hydrochloride

77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2C4H11NO3*2H(1+)*[H3NC(CH2O)3]CrMo6O18(OH)3(2-)

Conditions
ConditionsYield
Stage #1: 3H3N*3H(1+)*[CrMo6O18(OH)6](3-); 2-amino-2-hydroxymethyl-1,3-propanediol In water at 130℃; for 13h;
Stage #2: tris hydrochloride In water at 20℃; for 0.166667h;		90%
1185-53-1

tris hydrochloride

77-76-9

2,2-dimethoxy-propane

53104-32-8

(5-amino-2,2-dimethyl-1,3-dioxan-5-yl)methanol

Conditions
ConditionsYield
With toluene-4-sulfonic acid; N,N-dimethyl-formamide for 12h; Ambient temperature;86%
Stage #1: tris hydrochloride; 2,2-dimethoxy-propane With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 20℃; for 60h;
Stage #2: With triethylamine In methanol; N,N-dimethyl-formamide Sonication;
Stage #3: With triethylamine In methanol; ethyl acetate; N,N-dimethyl-formamide at 20℃; for 0.166667h;		86%
Stage #1: tris hydrochloride; 2,2-dimethoxy-propane; toluene-4-sulfonic acid In N,N-dimethyl-formamide at 20℃; for 18h;
Stage #2: With triethylamine In ethyl acetate for 0.5h;		85%
1185-53-1

tris hydrochloride

66-99-9

β-naphthaldehyde

253437-24-0

5-amino-5-hydroxymethyl-2-(2-naphthyl)-1,3-dioxane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 12h; Condensation; Heating;85%
1185-53-1

tris hydrochloride

66-77-3

1-naphthaldehyde

253437-27-3

5-amino-5-hydroxymethyl-2-(1-naphthyl)-1,3-dioxane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 12h; Condensation; Heating;82%
35718-08-2

propargyl chloroformate

1185-53-1

tris hydrochloride

C8H13NO5

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 19h;80%

Tris(hydroxymethyl)aminomethanehydrochloride Chemical Properties

Molecular Structure:

Molecular Formula: C4H12ClNO3
Molecular Weight: 157.596
IUPAC Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride
Synonyms of Tris hydrochloride (CAS NO.1185-53-1): 2-Amino-2-hydroxymethyl-1,3-propanediol hydrochloride ; EINECS 214-684-5 ; Tris chloride ; Tris hydrochloride buffer ; Tris(hydroxymethyl)aminomethane hydrochloride ; Trizma hydrochloride ; Tromethamine HCl ; Tris(hydroxymethyl)aminomethanehydrochloride ; UNII-383V75M34E ; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride ; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1)
CAS NO: 1185-53-1
Product Categories:  Buffer
Melting Point: 150-152 °C
H bond acceptors: 4
H bond donors: 5
Freely Rotating Bonds: 7
Polar Surface Area: 30.93 Å2
Flash Point: 169.7 °C
Enthalpy of Vaporization: 69.73 kJ/mol
Boiling Point: 357 °C at 760 mmHg
Vapour Pressure: 1.57E-06 mmHg at 25°C

Tris(hydroxymethyl)aminomethanehydrochloride Uses

 Tris hydrochloride (CAS NO.1185-53-1) is used as a organic intermediate.
 

Tris(hydroxymethyl)aminomethanehydrochloride Safety Profile

Safety Information of Tris hydrochloride (CAS NO.1185-53-1):
Hazard Codes:Xi  
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing  
WGK Germany:3
F:3
HS Code:29221980

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