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Uridine 5'-Monophosphate Disodium Salt Hydrate
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Name

Uridine 5'-Monophosphate Disodium Salt Hydrate

 EINECS 222-211-9
CAS No. 3387-36-8 Density 1.865g/cm3
PSA 186.78000 LogP -1.85850
Solubility 40 g/100 mL (20 °C) in water Melting Point 208-210 °C
Formula C9H11N2Na2O9P Boiling Point N/A
Molecular Weight 368.148 Flash Point N/A
Transport Information N/A Appearance Crystalline
Safety 22-24/25-36-26 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 3387-36-8 (Disodium uridine-5'-monophosphate) Hazard Symbols IrritantXi
Synonyms

5'-Uridylicacid, disodium salt (7CI,8CI,9CI);5'-UMP disodium salt;Disodium 5'-UMP;Disodium 5'-uridylate;Disodium UMP;Disodium uridine 5'-phosphate;NSC 20257;UMP disodium salt;Uridine5'-(dihydrogen phosphate) disodium salt;Uridine 5'-monophosphate disodiumsalt;Uridylic acid disodium salt;Disodium uridine-5'-monophosphate;

Article Data 8

Uridine 5'-Monophosphate Disodium Salt Hydrate Synthetic route

uridine 5'-(5-dimethylaminoisoquinolin-1-yl)methylphosphate

A

3387-36-8

disodium uridine-5'-monophosphate

B

75795-45-8

5-dimethylamino-1-hydroxymethylisoquinoline

Conditions
ConditionsYield
With snake venom phosphodiesterase for 3h; enzymatic hydrolysis; var.: pH;

uridine 5'-(5-dimethylamino-2-oxidoisoquinolin-1-yl)methylphosphate

A

3387-36-8

disodium uridine-5'-monophosphate

B

75795-49-2

5-dimethylamino-1-hydroxymethylisoquinolin-2-oxide

Conditions
ConditionsYield
With sodium acetate; snake venom phosphodiesterase at 37℃; for 3h; enzymatic hydrolysis, pH=8; half-life=7 h (pH=4.1), 12 h (pH=10.1), 24 h (pH=7.1), T=37 deg C;
154-85-8

orotic acid sodium salt

87372-47-2, 94902-32-6, 108321-05-7, 129136-58-9

5-phospho-D-ribosyl α-1-pyrophosphate

3387-36-8

disodium uridine-5'-monophosphate

Conditions
ConditionsYield
With DL-dithiothreitol; magnesium chloride for 192h; PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase; Yield given;
58-96-8

uridine

3387-36-8

disodium uridine-5'-monophosphate

Conditions
ConditionsYield
Multistep reaction.;

orotidine 5‘-monophosphate trisodium salt

3387-36-8

disodium uridine-5'-monophosphate

Conditions
ConditionsYield
With ODCase from Methanobacterium thermoautotrophicum In various solvent(s) at 55℃; pH=7.5; Enzyme kinetics; Further Variations:; Temperatures;
With orotidine 5'-monophosphate decarboxylase mutant Q215A/Y217F/R235A In aq. buffer at 25℃; pH=7.1; Kinetics; Reagent/catalyst; Enzymatic reaction;
532-20-7, 613-83-2, 7261-25-8, 7687-39-0, 13221-22-2, 14795-83-6, 15761-67-8, 20074-49-1, 25545-03-3, 25545-04-4, 32445-75-3, 34436-17-4, 36441-93-7, 36468-53-8, 37110-85-3, 37388-49-1, 38029-69-5, 40461-77-6, 40461-89-0, 41546-19-4, 41546-20-7, 41546-21-8, 41546-26-3, 41546-29-6, 41546-30-9, 41546-31-0, 126872-16-0, 131064-98-7

D-Ribose

3387-36-8

disodium uridine-5'-monophosphate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Na2ATP, MgCl2*6H2O, PEP-K+, DTT, K2HPO4, Na2EDTA / 72 h / PAN-immobilized pyruvate kinase, adenylate kinase, PRPP synthetase, pH 7.5
2: MgCl2*6H2O, DTT / 192 h / PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase
View Scheme
108321-99-9, 150713-51-2

α,β-D-ribofuranose-5-phophate disodium salt

3387-36-8

disodium uridine-5'-monophosphate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 mmol / Na2ATP, MgCl2*6H2O, PEP-K+, K2HPOu, Na2EDTA / 96 h / 30 °C / immobilized PRPP synthetase, pyruvate kinase, adenylate kinase, pH 7.4
2: MgCl2*6H2O, DTT / 192 h / PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase
View Scheme
4578-31-8

adenosine-5'-monophosphate disodium salt

3387-36-8

disodium uridine-5'-monophosphate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / Dowex 50 W-X8 (H+ form) / H2O / 0.14 h / Heating
2: 70 mmol / Na2ATP, MgCl2*6H2O, PEP-K+, K2HPOu, Na2EDTA / 96 h / 30 °C / immobilized PRPP synthetase, pyruvate kinase, adenylate kinase, pH 7.4
3: MgCl2*6H2O, DTT / 192 h / PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase
View Scheme

C9H13N3O11P2(2-)*2Na(1+)

3387-36-8

disodium uridine-5'-monophosphate

Conditions
ConditionsYield
With water; zinc(II) cation pH=5.5;
102-82-9

tributyl-amine

3387-36-8

disodium uridine-5'-monophosphate

uridine 5′-monophosphate tributylammonium salt

Conditions
ConditionsYield
Stage #1: disodium uridine-5'-monophosphate With DOWEX IR100S resin In water Industrial scale;
Stage #2: tributyl-amine In water at 15 - 25℃; pH=6.5 - 7.5; Industrial scale;		91.4%
With DOWEX IR100S resin In water at 15 - 25℃; pH=6.5 - 7.5; Industrial scale;91.4%
With DOWEX 50WX2-200 (H)

Uridine 5'-Monophosphate Disodium Salt Hydrate Specification

Uridine 5'-Monophosphate Disodium Salt Hydrate, with the CAS NO.3387-36-8, is also called Disodium [(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate; 5'-UMP disodium; CCRIS 6562; Disodium 5'-UMP; Disodium 5'-uridylate; Disodium UMP ; Disodium uridine 5'-monophosphate; Disodium uridine 5'-phosphate; EINECS 222-211-9 ; NSC 20257; Uridine 5'MP, disodium salt; Uridine-5-monophosphate disodium salt. It belongs to Biochemistry; Nucleosides, Nucleotides & Related Reagents; Nucleotides and their analogs; Nucleic acids. Uridine 5'-Monophosphate Disodium Salt Hydrate is used as flavoring agent.

Physical properties about Uridine 5'-Monophosphate Disodium Salt Hydrate are: (1)ACD/LogP: -1.583; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): -4.92; (4)ACD/LogD (pH 7.4): -5.90; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4):1.00; (9)#H bond acceptors: 11; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 6

Uses of Uridine 5'-Monophosphate Disodium Salt Hydrate: Uridine 5'-Monophosphate Disodium Salt Hydrate is used as flavoring agent: nucleotide added to the milk to increase volume to make it closer to human milk composition, increase resistance to infants and young children. And it can be used as auxiliary liver disease drug. It also used as production of intermediate nucleic acid drugs asn health food and biochemical reagents. And it for the manufacture of uridine triphosphate (UTP), poly gland urine, drugs such Furtulon.

When you are using this chemical, please be cautious about it as the following:
1. Do not breathe dust;
2. Avoid contact with skin and eyes;
3. Wear suitable protective clothing;
4. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C9H13N2O9P.2Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7+,8-;;/m1../s1;
(2)InChIKey=KURVIXMFFSNONZ-WAJQJQIOSA-L;
(3)Smilesc1cn(c(=O)[nH]c1=O)[C@H]2[C@H]([C@@H]([C@H](O2)COP(=O)([O-])[O-])O)O.[Na+].[Na+]

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 3394mg/kg (3394mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
mouse LD50 oral > 12gm/kg (12000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
mouse LD50 subcutaneous 3698mg/kg (3698mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
rat LD50 intraperitoneal 3111mg/kg (3111mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
rat LD50 oral > 12gm/kg (12000mg/kg)   Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
rat LD50 subcutaneous > 6gm/kg (6000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"		 Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.

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