- Vardenafil dihydrochloride
- Vardenafil hydrochloride
- Vardenafil hydrochloride trihydrate
- 224785-91-5Vardenafil hydrochloride
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Cas Database |
| Name |
Vardenafil hydrochloride trihydrate |
EINECS | 200-835-2 |
| CAS No. | 224785-90-4 | Density | 1.37 g/cm3 |
| PSA | 121.28000 | LogP | 4.63100 |
| Solubility | Soluble in water and alcohol | Melting Point |
230-235 °C |
| Formula | C23H32N6O4S | Boiling Point | 692.2 °C at 760 mmHg |
| Molecular Weight | 488.611 | Flash Point | 372.5 °C |
| Transport Information | N/A | Appearance | White crystalline powder |
| Safety | 16-36/37 | Risk Codes | 11-20/21/22-36 |
| Molecular Structure |
|
Hazard Symbols | F,Xn |
| Synonyms |
Piperazine,1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-(9CI);2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one;Nuviva;BAY 38-9456;1-((3-(3,4-Dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine;Vivanza; |
Article Data | 12 |
Vardenafil hydrochloride trihydrate Synthetic route
- 5308-25-8
4-ethylpiperazine
- 224789-21-3
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
- 224785-90-4
vardenafil
| Conditions | Yield |
|---|---|
| Stage #1: 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one With chlorosulfonic acid at 0 - 22℃; for 0.75h; Stage #2: 4-ethylpiperazine In dichloromethane at -3 - 25℃; for 0.75h; Product distribution / selectivity; |
- 5308-25-8
4-ethylpiperazine
- 224789-26-8
4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride
- 224785-90-4
vardenafil
| Conditions | Yield |
|---|---|
| In dichloromethane |
- 224789-21-3
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
- 224785-90-4
vardenafil
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: chlorosulfonic acid / dichloromethane / 24 h / 23 - 90 °C 2: dichloromethane View Scheme |
- 5308-25-8
4-ethylpiperazine
- 224789-21-3
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
- 224785-90-4
vardenafil
| Conditions | Yield |
|---|---|
| Stage #1: 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one With chlorosulfonic acid at 0 - 22℃; for 0.75h; Stage #2: 4-ethylpiperazine In dichloromethane at -3 - 25℃; for 0.75h; Product distribution / selectivity; |
- 224789-21-3
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
- 224785-90-4
vardenafil
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: chlorosulfonic acid / dichloromethane / 24 h / 23 - 90 °C 2: dichloromethane View Scheme |
- 5308-25-8
4-ethylpiperazine
- 224789-26-8
4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride
- 224785-90-4
vardenafil
| Conditions | Yield |
|---|---|
| In dichloromethane |
- 224785-90-4
vardenafil
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water; acetone at 50℃; Solvent; Temperature; pH-value; Reagent/catalyst; | 77% |
- 224785-90-4
vardenafil
| Conditions | Yield |
|---|---|
| With hydrogenchloride; water In acetone at 29 - 55℃; for 0.5h; |
- 224785-90-4
vardenafil
| Conditions | Yield |
|---|---|
| Stage #1: vardenafil With water In acetone at 28℃; for 0.166667h; Stage #2: With hydrogenchloride; water In acetone at 5 - 55℃; for 0.5h; Stage #3: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethylpiperazine dihydrochloride dihydrate In acetone at 3℃; |
- 224785-90-4
vardenafil
| Conditions | Yield |
|---|---|
| Stage #1: vardenafil With hydrogenchloride; water In acetone at 5 - 56℃; for 0.5h; Stage #2: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethylpiperazine dihydrochloride dihydrate In acetone at 3℃; |
Vardenafil hydrochloride trihydrate Chemical Properties
IUPAC Name: 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one
Synonyms of Vardenafil hydrochloride trihydrate (CAS NO.224785-90-4): 1-((3-(3,4-Dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine ; 2-(2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo(5,1-f)(1,2,4)triazin-4-one ; BAY 38-9456 ; BAY38-9456 ; HSDB 7304 ; Levitra ; UNII-UCE6F4125H ; Vivanza ; Piperazine, 1-((3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)(1,2,4)triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethyl-
CAS NO: 224785-90-4
Classification Code: Enzyme Inhibitors ; Phosphodiesterase 5 Inhibitors ; Phosphodiesterase Inhibitors
Molecular Formula of Vardenafil hydrochloride trihydrate (CAS NO.224785-90-4): C23H32N6O4S
Molecular Weight: 488.603
Molecular Structure:
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Melting Point: 214-216°C
Polar Surface Area: 108.72 Å2
Index of Refraction: 1.656
Molar Refractivity: 130.63 cm3
Molar Volume: 355.4 cm3
Surface Tension: 53.3 dyne/cm
Density of Vardenafil hydrochloride trihydrate (CAS NO.224785-90-4): 1.37 g/cm3
Flash Point: 372.5 °C
Enthalpy of Vaporization: 101.43 kJ/mol
Boiling Point: 692.2 °C at 760 mmHg
Vapour Pressure: 5.17E-19 mmHg at 25°C
Vardenafil hydrochloride trihydrate Uses
Vardenafil hydrochloride trihydrate (CAS NO.224785-90-4) is used as a selective phsphodiesterase type 5 (PDE5) inhibitor.
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