- VINDESINE
- Vindesine sulfate
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| Name |
Vindesine sulfate |
EINECS | 261-984-7 |
| CAS No. | 59917-39-4 | Density | 1.41 g/cm3 |
| PSA | 247.80000 | LogP | 3.80150 |
| Solubility | N/A | Melting Point |
>250oC |
| Formula | C43H55N5O7.H2SO4 | Boiling Point | N/A |
| Molecular Weight | 852.018 | Flash Point | N/A |
| Transport Information | N/A | Appearance | Amorphous solid |
| Safety | 26-36 | Risk Codes | 40 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt);4-Desacetilvinblastina-C-3-carboxamida sulfato [Spanish];Fildesin (TN);Vindesine sulfate salt;Vindesine sulfate [USAN:JAN];Vindesine sulfate (JAN/USAN);Vindesina sulfato [Spanish];Fildesin;Desacetylvinblastine amide sulfate, compd. with mannitol;Lilly 99094;Desacetylvinblastine amide sulfate compound with mannitol;DAVA;3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate (1:1) (salt);Eldesine;3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate;Vincaleukoblastine, 3-(aminocarbonyl)-O(4)-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt), mixt. with D-mannitol;Eldisine;23-Amino-O(sup 4)-deacetyl-23-demethoxyvincaleukoblastine sulfate;Vincaleukoblastine, 3-(aminocarbonyl)-O(sup 4)-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt);Vincaleukoblastine,3-(aminocarbonyl)-O4- deacetyl-3-de(methoxycarbonyl)-,sulfate (1:1) (salt);Desacetylvinblastine amide sulfate;Vincaleukoblastine, 23-amino-O(sup 4)-deacetyl-23-demethoxy-, sulfate; |
Vindesine sulfate Chemical Properties
The molecular structure of Vindesine sulfate (59917-39-4) as follow:
EINECS: 261-984-7
Molecular formula: C43H57N5O11S
Formula weight: 852
Synonyms: 23-amino-o(sup4)-deacetyl-23-demethoxyvincaleukoblastine sulfate ; 23-amino-o(sup4)-deacetyl-23-demethoxy-vincaleukoblastin sulfate ; 3-carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate ; 4-desacetilvinblastina-c-3-carboxamida sulfato ; desacetylvinblastine amide sulfate ; eldesine ; eldisine
Melting point: >250 ℃
Appearance: Amorphous solid
The product categories about vindesine sulfate (59917-39-4) belong to intermediates & fine chemicals; pharmaceuticals.
Vindesine sulfate Uses
Vindesine sulfate (59917-39-4) is a synthetic derivative of the dimeric Catharanthus alkaloid vinblastine. It is used as a kind of anticancer drugs and the extensive usage is applied in antineoplastic combined chemotherapy protocols.
Vindesine sulfate Toxicity Data With Reference
| mouse | LD50 | intraperitoneal | 3500ug/kg (3.5mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983. |
| mouse | LD50 | intravenous | 6300ug/kg (6.3mg/kg) | Journal of Toxicology and Environmental Health. Vol. 1, Pg. 843, 1976. | |
| mouse | LD50 | subcutaneous | 6800ug/kg (6.8mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983. | |
| rat | LD50 | intraperitoneal | 1050ug/kg (1.05mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983. |
| rat | LD50 | intravenous | 1920ug/kg (1.92mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983. |
| rat | LD50 | subcutaneous | 1790ug/kg (1.79mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983. |
Vindesine sulfate Safety Profile
Poison by subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.
Hazard codes: 
Xn Harmful
Risk statements: 40 Limited evidence of a carcinogenic effect.
Safety statements: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36 Wear suitable protective clothing.
Vindesine sulfate Specification
Vindesine sulfate (59917-39-4) should be stored at 2-8 ℃. As an anticancer drug, the major side effects of it are myelosuppression and neurotoxicity.
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