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Zinc pyrithione

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Zinc pyrithione

EINECS 236-671-3
CAS No. 13463-41-7 Density 1.782 g/cm3 (25oC)
Solubility <0.1 g/100 mL at 21 °C in water Melting Point 262oC
Formula 2(C5H4NOS).Zn Boiling Point 253.8 °C at 760 mmHg
Molecular Weight 317.68 Flash Point 107.3 °C
Transport Information UN 2811 6.1/PG 2 Appearance Fine beige granules
Safety 26-28-36/37/39-45 Risk Codes 24/25-26-37/38-41
Molecular Structure Molecular Structure of 13463-41-7 (Zinc pyrithione) Hazard Symbols VeryT+
Synonyms

2(1H)-Pyridinethione, 1-hydroxy-, zinc complex;2-Mercaptopyridine 1-oxide zinc salt;2-Pyridinethiol-1-oxide, zinc salt;AI3-62421;BC-J;Biocut ZP;Bis(1-hydroxy-2(1H)-pyridinethionato)zinc;

 

Zinc pyrithione Chemical Properties

The Molecular Structure of Zinc pyrithione (CAS NO.13463-41-7):

Molecular formula :C10H8N2O2S2Zn
Molar mass: 317.70 g/mol 
Nominal Mass: 316 Da
Average Mass: 317.7217 Da
Monoisotopic Mass: 315.931864 Da
EINECS: 236-671-3  
IUPAC Name: zinc 1-oxidopyridine-2-thione   
Product Categories: Organometallics;Heterocyclic Compounds;Classes of Metal Compounds;Transition Metal Compounds;Zn (Zinc) Compounds 
Water Solubility: Insoluble (<0.1 g/100 mL at 21 ºC)
InChI
InChI=1/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2/rC10H8N2O2S2Zn/c13-11-7-3-1-5-9(11)15-17-16-10-6-2-4-8-12(10)14/h1-8H
Smiles
c1([n+](cccc1)[O-])S[Zn]Sc1[n+](cccc1)[O-]

Zinc pyrithione Uses

1. Zinc pyrithione (CAS NO.13463-41-7) can be  used as an antifungal and antibacterial agent. It  has antibacterial properties and is effective against many pathogens from the streptococcus and staphylococcus class.It is best known  in treating dandruff and seborrhoeic dermatitis.It is also used in treating  psoriasis, eczema, fungus,ringworm,  athletes foot, dry skin, tinea,atypical dermatitis,  and vitiligo.
2.Used in paint:due to its low solubility in water (8 ppm at neutral pH),  Zinc pyrithione (CAS NO.13463-41-7) is suitable for use in outdoor paints and other products that provide protection against mildew and algae. When used in latex paints and the water contains high amount of iron, a sequestering agent that will preferentially bind the iron ions is needed. Its decomposition by ultraviolet light is slow, providing years of protection even against direct sunlight.

Zinc pyrithione Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 600mg/kg (600mg/kg)   Clinical Toxicology. Vol. 13, Pg. 1, 1978.
Link to PubMed
dog LDLo intravenous 25mg/kg (25mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966.
Link to PubMed
guinea pig LD50 oral > 2gm/kg (2000mg/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 425, 1965.
mammal (species unspecified) LC50 inhalation 140mg/m3/4H (140mg/m3)   United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0790-1035,
monkey LDLo intravenous 25mg/kg (25mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966.
 
mouse LD50 intraperitoneal 26800ug/kg (26.8mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1067, 1974.
mouse LD50 oral 160mg/kg (160mg/kg)   Clinical Toxicology. Vol. 13, Pg. 1, 1978.
 
mouse LD50 subcutaneous 730mg/kg (730mg/kg)   Clinical Toxicology. Vol. 13, Pg. 1, 1978.
 
rabbit LD50 skin 100mg/kg (100mg/kg)   Yakkyoku. Pharmacy. Vol. 32, Pg. 965, 1981.
rabbit LDLo intravenous 10mg/kg (10mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966.
 
rat LC50 inhalation 140mg/m3/4H (140mg/m3) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. OTS0527753-1,
rat LD50 oral 177mg/kg (177mg/kg)   Toxicology Annual. Vol. 3, Pg. 1, 1979.

Zinc pyrithione Safety Profile

Hazard Codes: VeryT+
Risk Statements: 24/25-26-37/38-41 
R24/25: Toxic in contact with skin and if swallowed 
R26: Very Toxic by inhalation 
R37/38: Irritating to respiratory system and skin
R41: Risk of serious damage to the eyes
Safety Statements: 26-28-36/37/39-45 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28: After contact with skin, wash immediately with plenty of soap-suds
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: ZH0950000
HazardClass: 6.1(b)
PackingGroup: III

Zinc pyrithione Specification

 Zinc pyrithione (CAS NO.13463-41-7) is also called as 1-Hydroxy-2-pyridine thione, zn salt ; 1-Hydroxypyridine-2-thione zinc ; 1-Hydroxypyridine-2-thione zinc salt ; 2-Pyridinethiol 1-oxide zinc salt ; 2-Mercaptopyridine n-oxide zinc ; 2-Mercaptopyridine n-oxide zinc salt ; 2-Mercaptopyridine-1-oxide zinc salt ; Mercaptopyridine n-oxide zinc salt .

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