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| Name |
Zipeprol dihydrochloride |
EINECS | 252-192-2 |
| CAS No. | 34758-84-4 | Density | 1.108g/cm3 |
| PSA | 45.17000 | LogP | 4.22010 |
| Solubility | N/A | Melting Point |
231° |
| Formula | C23H32 N2 O3 . 2 Cl H | Boiling Point | 507.7°Cat760mmHg |
| Molecular Weight | 440.46 | Flash Point | 260.8°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and parenteral routes. Human systemic effects by ingestion: convulsions, coma. An antitussive agent. When heated to decomposition it emits toxic fumes of NOx and ClH. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1-Piperazineethanol,4-(2-methoxy-2-phenylethyl)-a-(methoxyphenylmethyl)-, dihydrochloride (9CI); 3024CERM; Antituxil Z;CERM 3024; Citizeta; Mirsol; Respilene; Respirase; Zipeprol dihydrochloride;Zitoxil |
Zipeprol dihydrochloride Chemical Properties
IUPAC Name: 1-Methoxy-3-[4-(2-methoxy-2-phenylethyl)piperazin-1-yl]-1-phenylpropan-2-ol dihydrochloride
Synonyms: 1-Methoxy-3-[4-(2-methoxy-2-phenylethyl)piperazin-1-yl]-1-phenylpropan-2-ol dihydrochloride ; 1-Piperazineethanol, 4-(2-methoxy-2-phenylethyl)-alpha-(methoxyphenylmethyl)-, hydrochloride (1:2) ; 1-(2-Hydroxy-3-methoxy-3-phenylpropyl)-4-(2-methoxy-2-phenylethyl)piperazine dihydrochloride ; 1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydroxy-3-methoxy-3-phenyl)propylpiperazine dihydrochlroide
CAS NO:34758-84-4
Molecular Formula of 1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydro-xy-3-methoxy-3-phenyl)propyl-piperazine dihydrochloride (CAS NO.34758-84-4) :C23H34Cl2N2O3
Molecular Weight of 1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydro-xy-3-methoxy-3-phenyl)propyl-piperazine dihydrochloride (CAS NO.34758-84-4) :457.43
Molecular Structure of 1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydro-xy-3-methoxy-3-phenyl)propyl-piperazine dihydrochloride (CAS NO.34758-84-4) :.png)
EINECS: 252-192-2
Flash Point: 260.8 °C
Enthalpy of Vaporization: 81.9 kJ/mol
Boiling Point: 507.7 °C at 760 mmHg
Vapour Pressure: 3.95E-11 mmHg at 25°C
Melting point: 231°C
Appearance:White crystal or crystalline powder, odorless, bitter taste.
Solubility:Soluble in water and methanol
Zipeprol dihydrochloride Uses
1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydro-xy-3-methoxy-3-phenyl)propyl-piperazine dihydrochloride (CAS NO.34758-84-4) is used for cough by various causes .
Zipeprol dihydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 154mg/kg/3D-I (154mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Lancet. Vol. 1, Pg. 45, 1984. |
| dog | LD50 | oral | 228mg/kg (228mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981. |
| dog | LDLo | intravenous | 54600ug/kg (54.6mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 523, 1976. |
| human | TDLo | oral | 11mg/kg (11mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA | Lancet. Vol. 1, Pg. 45, 1984. |
| man | TDLo | oral | 10714ug/kg (10.714mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Lancet. Vol. 1, Pg. 45, 1984. |
| mouse | LD50 | intraperitoneal | 116mg/kg (116mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981. |
| mouse | LD50 | intravenous | 44300mg/kg (44300mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981. |
| mouse | LD50 | oral | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 523, 1976. | |
| mouse | LD50 | subcutaneous | 158mg/kg (158mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981. |
| rabbit | LD50 | oral | 173mg/kg (173mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981. |
| rat | LD50 | intraperitoneal | 77600ug/kg (77.6mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981. |
| rat | LD50 | intravenous | 32700ug/kg (32.7mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981. |
| rat | LD50 | oral | 435mg/kg (435mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981. |
| rat | LD50 | subcutaneous | 139mg/kg (139mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981. |
| women | TDLo | oral | 18mg/kg (18mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Lancet. Vol. 1, Pg. 45, 1984. |
Zipeprol dihydrochloride Safety Profile
Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and parenteral routes. Human systemic effects by ingestion: convulsions, coma. An antitussive agent. When heated to decomposition it emits toxic fumes of NOx and ClH.
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