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CAS No.: | 10043-35-3 |
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Name: | Boric acid |
Molecular Structure: | |
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Formula: | BH3O3 |
Molecular Weight: | 61.833 |
Synonyms: | Boracic acid;Boron trihydroxide; |
EINECS: | 233-139-2 |
Density: | 1.438 g/cm3 |
Melting Point: | 169 °C |
Boiling Point: | 219-220 °C (9.7513 mmHg) |
Solubility: | 49.5 g/L (20 °C) in water |
Appearance: | white crystalline solid |
Hazard Symbols: |
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Risk Codes: | 36/37/38-60-63-62 |
Safety: | 26-36-53-45-37/39-36/37/39-22 |
PSA: | 60.69000 |
LogP: | -2.05180 |
The IUPAC name of OrthoOrthoboric acid is Orthoboric acid. With the CAS registry number 10043-35-3, it is also named as Boron hydroxide. The product's categories are Industrial/Fine Chemicals; Inorganics; BI - BZSpectroscopy; AAS; AAS CRMsAlphabetic; AASSpectroscopy; Application CRMs; B; Matrix Selection; Nitrate; Spectroscopy; Buffers A to ZBiological Buffers; SigmaUltra Buffers; Biological Buffers; Buffer Convenience Packaging; Buffer TabletsBiological Buffers; A-B, Puriss p.a. ACS; Analytical Reagents for General Use; Puriss p.a. ACS; Buffers A to Z; AlphabeticalMolecular Biology; BioUltra Buffers; etc., and the other registry numbers are 12795-04-9; 30698-98-7. Besides, it is white crystalline solid, which should be stored in dry, clean, cool and ventilated warehouse. In addition, its molecular formula is H3BO3 and molecular weight is 61.83.
The other characteristics of this product can be summarized as: (1)EINECS: 201-191-5; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5):; (6)ACD/KOC (pH 7.4):; (7)#H bond acceptors: 3; (8)#H bond donors: 3; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 60.69 Å2; (11)Index of Refraction: 1.385; (12)Molar Refractivity: 10.083 cm3; (13)Molar Volume: 43.003 cm3; (14)Polarizability: 3.997×10-24cm3; (15)Surface Tension: 59.198 dyne/cm; (16)Density: 1.438 g/cm3; (17)Melting point: 169 °C; (18)Boiling point: 300 °C; (19)Water solubility: 49.5 g/L (20 °C); (20)Vapor pressure: 2.6 mm Hg ( 20 °C).
Preparation of OrthoOrthoboric acid: this chemical can be prepared by the reaction of Sodium tetraborate decahydrate with Hydrochloric acid:
Na2B4O7.10H2O + 2 HCl → 4 B(OH)3 + 2 NaCl + 5 H2O
Uses of OrthoOrthoboric acid: this chemical is used for minor burns or cuts as an antiseptic. It is also used for acne treatment as an anti-bacterial. Its buffer is widely used for the electrophoresis of nucleic acids. What's more, it can be used as an insecticide to prevent and destroy existing wet and dry rot in timbers. It also can be used to lubricate carrom boards. It is mainly used for the manufacture of monofilament fiberglass usually referred to as textile fiberglass in industry. And it is used as a neutron poison to slow down the rate at which fission is occurring in nuclear power plants. Furthermore, it is often used to reduce surface oxidation and firescale from forming on metals during annealing and soldering operations in combination with denatured alcohol. It is also used in the production of the glass in LCD flat panel displays.
When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing, gloves and eye/face protection. Moreover, it is risk of impaired fertility. It is also possible risk of harm to the unborn child. Please do not breathe dust. And avoid exposure - obtain special instructions before use. Additionally, in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: B(O)(O)O
(2)InChI: InChI=1S/BH3O3/c2-1(3)4/h2-4H
(3)InChIKey: KGBXLFKZBHKPEV-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | LDLo | skin | 1500mg/kg (1500mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Quarterly Journal of Pharmacy & Pharmacology. Vol. 6, Pg. 714, 1933. |
child | LDLo | skin | 4gm/kg/4D (4000mg/kg) | Muenchener Medicinische Wochenschrift. Vol. 52, Pg. 763, 1905. | |
child | TDLo | oral | 500mg/kg (500mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Toxicology, Clinical Toxicology. Vol. 24, Pg. 269, 1986. |
dog | LDLo | oral | 1780mg/kg (1780mg/kg) | BRAIN AND COVERINGS: MENINGEAL CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: NAUSEA OR VOMITING | JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945. |
dog | LDLo | parenteral | 1gm/kg (1000mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Rassegna di Terapia e Patologia Clinica. Vol. 1, Pg. 472, 1929. |
dog | LDLo | subcutaneous | 1gm/kg (1000mg/kg) | BRAIN AND COVERINGS: MENINGEAL CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: NAUSEA OR VOMITING | JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945. |
guinea pig | LD50 | subcutaneous | 1200mg/kg (1200mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950, |
guinea pig | LDLo | oral | 1gm/kg (1000mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: OTHER CHANGES | Revista de la Asociacion Medica Argentina. Vol. 46, Pg. 1493, 1932. |
infant | LDLo | oral | 934mg/kg (934mg/kg) | JAMA, Journal of the American Medical Association. Vol. 90, Pg. 382, 1928. | |
infant | LDLo | skin | 1200mg/kg (1200mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | JAMA, Journal of the American Medical Association. Vol. 129, Pg. 332, 1945. |
infant | LDLo | subcutaneous | 1100mg/kg (1100mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950, |
infant | TDLo | oral | 800mg/kg/4W-I (800mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | Archives of Disease in Childhood. Vol. 58, Pg. 737, 1983. |
man | LDLo | oral | 429mg/kg (429mg/kg) | CARDIAC: OTHER CHANGES KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 345, 1993. |
man | LDLo | skin | 2430mg/kg (2430mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE | JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945. |
man | LDLo | unreported | 147mg/kg (147mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
man | TDLo | unreported | 170mg/kg (170mg/kg) | BEHAVIORAL: WAKEFULNESS BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING | Rassegna di Terapia e Patologia Clinica. Vol. 1, Pg. 472, 1929. |
mouse | LD50 | intravenous | 1240mg/kg (1240mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 117, 1961. |
mouse | LD50 | oral | 3450mg/kg (3450mg/kg) | JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945. | |
mouse | LD50 | subcutaneous | 1740mg/kg (1740mg/kg) | JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945. | |
mouse | LDLo | intraperitoneal | 800mg/kg (800mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964. |
rabbit | LDLo | intravenous | 800mg/kg (800mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964. |
rabbit | LDLo | oral | 4gm/kg (4000mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950, |
rabbit | LDLo | parenteral | 670mg/kg (670mg/kg) | Rassegna di Terapia e Patologia Clinica. Vol. 1, Pg. 472, 1929. | |
rabbit | LDLo | subcutaneous | 150mg/kg (150mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
rat | LCLo | inhalation | 28mg/m3/4H (28mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 27, 1982. | |
rat | LD50 | intravenous | 1330mg/kg (1330mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950, |
rat | LD50 | oral | 2660mg/kg (2660mg/kg) | JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945. | |
rat | LD50 | subcutaneous | 1400mg/kg (1400mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964. |
women | LDLo | oral | 200mg/kg (200mg/kg) | BEHAVIORAL: FLUID INTAKE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | Lancet. Vol. 2, Pg. 162, 1917. |
women | TDLo | oral | 400mg/kg (400mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 804, 1990. |