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| CAS No.: | 10136-57-9 |
|---|---|
| Name: | 5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE |
| Article Data: | 27 |
| Molecular Structure: | |
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|
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| Formula: | C10H8ClNO |
| Molecular Weight: | 193.633 |
| Synonyms: | 5-Chloromethyl-8-hydroxyquinoline;5-Chloromethyl-8-quinolinol;5-(chloromethyl)quinolin-8-ol; |
| Density: | 1.355 g/cm3 |
| Melting Point: | 180 °C |
| Boiling Point: | 388.1 ºC at 760 mmHg |
| Flash Point: | 188.5 ºC |
| PSA: | 33.12000 |
| LogP: | 3.48120 |
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| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 20℃; for 12h; | 91.4% |
| With hydrogenchloride In water at 0 - 60℃; for 10h; | 90% |
| With hydrogenchloride In water at 80℃; for 6h; | 87% |
- 4053-44-5
5-(hydroxymethyl)-8-hydroxyquinoline
- 10136-57-9
5-(chloromethyl)quinolin-8-ol
| Conditions | Yield |
|---|---|
| With thionyl chloride at 20℃; for 6h; |
- 10136-57-9
5-(chloromethyl)quinolin-8-ol
- 120014-30-4
debenzyldonepezil
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile for 8h; Reflux; | 88% |
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide for 48h; | 81% |
- 10136-57-9
5-(chloromethyl)quinolin-8-ol
- 1609078-44-5
(1-1-benzylpiperidin-4-yl)(prop-2-yn-1-yl-amino)acetonitrile
- 1609078-38-7
2-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)acetonitrile
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at 20℃; for 0.5h; | 80.6% |
| With triethylamine In dichloromethane at 20℃; for 0.5h; | 80.6% |
- 10136-57-9
5-(chloromethyl)quinolin-8-ol
- 81748-72-3
5-(aminomethyl)-8-hydroxyquinoline
- 1215290-53-1
5,5',5''-nitrilotris(methylene)triquinolin-8-ol
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile at 50℃; for 24h; | 73% |
- 10136-57-9
5-(chloromethyl)quinolin-8-ol
- 81748-72-3
5-(aminomethyl)-8-hydroxyquinoline
| Conditions | Yield |
|---|---|
| Stage #1: 5-(chloromethyl)quinolin-8-ol With hexamethylenetetramine In dimethyl sulfoxide at 20℃; Stage #2: With hydrogenchloride In water at 20℃; for 48h; | 70% |
| Stage #1: 5-(chloromethyl)quinolin-8-ol With potassium phtalimide In N,N-dimethyl-formamide at 150℃; for 5h; Stage #2: With hydrogenchloride In water at 150℃; for 9h; | |
| Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 5 h / 150 °C 2: hydrogenchloride / water / 20 °C / Reflux View Scheme |
- 10136-57-9
5-(chloromethyl)quinolin-8-ol
- 1609078-46-7
3-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)propanenitrile
- 1609078-40-1
3-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)propanenitrile
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at 0 - 20℃; | 69.5% |
- 10136-57-9
5-(chloromethyl)quinolin-8-ol
- 1609078-49-0
4-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)butanenitrile
- 1609078-42-3
4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at 0 - 20℃; | 65.4% |
| With triethylamine In dichloromethane at 0 - 20℃; | 65.4% |
- 110-85-0
piperazine
- 10136-57-9
5-(chloromethyl)quinolin-8-ol
- 22505-80-2
5,5'-(piperazine-1,4-diylbis(methylene))diquinolin-8-ol
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile at 20℃; for 72h; | 60% |
- Total:24 Page 1 of 1 1
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Chemistry
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Systematic Name: 5-(Chloromethyl)quinolin-8-ol
SMILES: ClCc1ccc(O)c2ncccc12
InChI: InChI=1/C10H8ClNO/c11-6-7-3-4-9(13)10-8(7)2-1-5-12-10/h1-5,13H,6H2
InChIKey: JGOBHUWKRDXZEY-UHFFFAOYAW
Empirical Formula: C10H8ClNO
Molecular Weight: 193.6296
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 2
Index of Refraction: 1.677
Molar Refractivity: 53.83 cm3
Molar Volume: 142.8 cm3
Surface Tension: 58.6 dyne/cm
Density: 1.355 g/cm3
Flash Point: 188.5 °C
Enthalpy of Vaporization: 66.22 kJ/mol
Boiling Point: 388.1 °C at 760 mmHg
Vapour Pressure: 1.41E-06 mmHg at 25 °C
Specification
8-Quinolinol,5-(chloromethyl)- (CAS NO.10136-57-9), its Synonyms are 5-(chloromethyl)quinolin-8-ol ; 5-Chloromethyl-8-quinolinol ; 5-Chloromethyl-8-hydroxyquinoline .