CAS No.101363-10-4,RUFLOXACIN Suppliers

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Basic Information

Molecular Structure:
CAS No.:	101363-10-4
Name:	RUFLOXACIN

Formula:	C₁₇H₁₈FN₃O₃S
Molecular Weight:	363.413
Synonyms:	Rufloxacin;
Density:	1.547 g/cm³
Boiling Point:	574.6 °C at 760 mmHg
Flash Point:	301.3 °C
PSA:	91.08000
LogP:	1.69920

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Specification

This chemical is called Rufloxacin, and its systematic name is 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid. With the molecular formula of C₁₇H₁₈FN₃O₃S, its molecular weight is 363.41. The CAS registry number of this chemical is 101363-10-4, and its product category is Active Pharmaceutical Ingredients. Additionally, it's a quinolone.

Other characteristics of the Rufloxacin can be summarised as followings: (1)ACD/LogP: 1.85; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.237 ; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 5.894; (7)ACD/KOC (pH 7.4): 1.635; (8)#H bond acceptors: 6; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 89.39 Å²; (12)Index of Refraction: 1.72; (13)Molar Refractivity: 92.765 cm³; (14)Molar Volume: 234.943 cm³; (15)Polarizability: 36.775×10^-24cm³; (16)Surface Tension: 79.036 dyne/cm; (17)Density: 1.547 g/cm³; (18)Flash Point: 301.317 °C; (19)Enthalpy of Vaporization: 90.558 kJ/mol; (20)Boiling Point: 574.616 °C at 760 mmHg; (21)Vapour Pressure: 0 mmHg at 25°C.

Production method of this chemical: The Rufloxacin could be obtained by the reactant of rufloxacin-1-oxide. This reaction needs the reagent of PCl₃, and the solvent of dimethylformamide. The yield is 59 %. In addition, this reaction should be taken for 2 hours at the ambient temperature.

Uses of this chemical: This chemical is used as quinolone antibiotics. It has significant antibacterial activity on orchid positive and negative bacteria, particularly enterobacteriaceae. It has high effect of treatment on bacterial prostatitis, too. Additionally, this chemical can treat the urinary tract infection, lower respiratory tract infection.

You can still convert the following datas into molecular structure:
1.SMILES: CN1CCN(CC1)c2c(cc3c4c2SCCn4cc(c3=O)C(=O)O)F
2.InChI: InChI=1/C17H18FN3O3S/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24/h8-9H,2-7H2,1H3,(H,23,24) 3.InChIKey: NJCJBUHJQLFDSW-UHFFFAOYAU