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Basic Information
| CAS No.: | 10210-17-0 |
|---|---|
| Name: | 3-(4-HYDROXYPHENYL)-1-PROPANOL |
| Article Data: | 49 |
| Molecular Structure: | |
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|
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| Formula: | C9H12 O2 |
| Molecular Weight: | 152.193 |
| Synonyms: | 1-Propanol,3-(p-hydroxyphenyl)- (6CI,7CI,8CI); 1-(4-Hydroxyphenyl)-3-propanol;3-(4-Hydroxyphenyl)-1-propanol; 3-(4-Hydroxyphenyl)propanol;3-(p-Hydroxyphenyl)-1-propanol; 3-(p-Hydroxyphenyl)propyl alcohol;4-(3-Hydroxypropyl)phenol; 4-Hydroxybenzenepropanol; Dihydro-p-coumaryl alcohol |
| EINECS: | 233-511-4 |
| Density: | 1.129 g/cm3 |
| Melting Point: | 51-54 °C(lit.) |
| Boiling Point: | 311.6 °C at 760 mmHg |
| Flash Point: | 154.4 °C |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-37/39 |
| PSA: | 40.46000 |
| LogP: | 1.31710 |
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Synthetic route
- 5597-50-2
3-(4-hydroxyphenyl)propionic acid methyl ester
- 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3-(4-hydroxyphenyl)propionic acid methyl ester With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 4 - 5h; Heating / reflux; Stage #2: With sodium hydroxide; water In tetrahydrofuran; ethyl acetate | 100% |
| Stage #1: 3-(4-hydroxyphenyl)propionic acid methyl ester With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 4 - 5h; Heating / reflux; Stage #2: With sodium hydroxide In tetrahydrofuran; water; ethyl acetate at 20℃; Stage #3: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate pH=7.0; | 100% |
| With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 4 - 5h; Heating / reflux; | 100% |
- 501-97-3
4-hydroxyphenylpropionic acid
- 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol
Conditions
| Conditions | Yield |
|---|---|
| With borane-THF; Trimethyl borate In tetrahydrofuran at 0℃; for 4h; Inert atmosphere; | 99% |
| With sodium tetrahydroborate; Trimethyl borate; dimethyl sulfate In tetrahydrofuran at 20℃; for 1.5h; | 98% |
| With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; | 98% |
- 3690-05-9
para-coumaryl alcohol
- 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol
Conditions
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 12h; | 98% |
- 54965-55-8
methyl 3-(4-acetyloxyphenyl)propanoate
- 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol
Conditions
| Conditions | Yield |
|---|---|
| With lithium borohydride In tetrahydrofuran at 70℃; for 22h; | 95.5% |
| With lithium aluminium tetrahydride; diethyl ether |
- 23795-02-0
3-(4-hydroxy-phenyl)-propionic acid ethyl ester
- 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol
Conditions
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere; | 95% |
| Stage #1: 3-(4-hydroxy-phenyl)-propionic acid ethyl ester With lithium aluminium tetrahydride In tetrahydrofuran for 6h; Heating / reflux; Stage #2: With ethyl acetate; sodium sulfate In tetrahydrofuran; water Stage #3: With hydrogenchloride In tetrahydrofuran; water pH=7.0; | 68% |
| With lithium aluminium tetrahydride In tetrahydrofuran at 55℃; for 12h; | 13.5 g |
| Multi-step reaction with 3 steps 1: 89.1 percent / K2CO3; NaI / acetone / 48 h / Heating 2: 66.2 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 3: 84.3 percent / H2 / 10 percent Pd/C / ethanol / 20 °C / 760 Torr View Scheme |
- 25823-43-2
3-(4-acetoxyphenyl)propyl acetate
- 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol
Conditions
| Conditions | Yield |
|---|---|
| With aluminum oxide In neat (no solvent) at 65℃; for 0.0416667h; microwave irradiation; | 92% |
- 61440-45-7
3-[4-(benzyloxy)phenyl]propan-1-ol
- 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In acetic acid | 89% |
| With hydrogen; palladium on activated charcoal In ethanol at 20℃; under 760 Torr; Hydrogenolysis; | 84.3% |
| With hydrogen; palladium on activated charcoal In ethanol Ambient temperature; | 0.149 g |
- 7400-08-0
p-Coumaric Acid
- 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol
Conditions
| Conditions | Yield |
|---|---|
| With whole cell cultures of dichomitus albidofuscus at 24℃; for 72h; Darkness; Microbiological reaction; | 82% |
| Multi-step reaction with 3 steps 1: aq. HCl / 6 h / Heating 2: H2 / 10percent Pd/C / methanol / 0.5 h / 760 Torr / Ambient temperature 3: LiBH4 / diethyl ether; toluene / 0.25 h / Heating View Scheme | |
| Multi-step reaction with 4 steps 1.1: pyridine / 1 h / 20 °C 2.1: chloroformic acid ethyl ester; triethylamine / 1,4-dioxane / 1 h / Inert atmosphere 2.2: 1 h / Inert atmosphere 3.1: potassium hydroxide / ethanol / 8 h / Inert atmosphere 4.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 6 h / 20 °C / 2250.23 Torr View Scheme |
- 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol
Conditions
| Conditions | Yield |
|---|---|
| aluminum oxide for 0.183333h; Irradiation; | 78% |
| With cerium(IV) triflate In acetonitrile at 20℃; for 0.25h; | 75% |
- 36294-23-2
4-(3-hydroxypropyl)-2,6-di-tert-butylphenol
- 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol
Conditions
| Conditions | Yield |
|---|---|
| at 324℃; for 11h; | 76% |
Raw Materials
Downstream Products
