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1025967-78-5

Basic Information
CAS No.: 1025967-78-5
Name: lifitegrast
Molecular Structure:
Molecular Structure of 1025967-78-5 (lifitegrast)
Formula: C29H24Cl2N2O7S
Molecular Weight: 615.48
Synonyms: lifitegrast;Lifitegrast, SAR 1118;L-Phenylalanine,N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-;N-[[2-(6-Benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-L-phenylalanine;SAR 1118;(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid;(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic
EINECS: -0
Density: 1.479±0.06 g/cm3(Predicted)
Melting Point:
Boiling Point: 811.9±65.0 °C(Predicted)
Flash Point:
Solubility:
Appearance:
Hazard Symbols:
Risk Codes:
Safety:
Transport Information:
PSA: 142.37000
LogP: 6.17690
Synthetic route

lifitegrast dicyclohexylamine salt

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
With phosphoric acid In dichloromethane; water at 50℃; for 0.5h;96%
1194550-67-8

((S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-methylsulfonyl)phenyl)propanoate

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
With formic acid; palladium 10% on activated carbon; triethylamine In tetrahydrofuran; methanol at 20℃; for 4h;95%
With formic acid; palladium 10% on activated carbon; triethylamine In tetrahydrofuran; methanol Reagent/catalyst; Solvent;n/a
With lithium hydroxide monohydrate In water; acetone at -5 - 0℃; for 1h; Reagent/catalyst; Solvent; Temperature;
With hydrogenchloride In water; acetonitrile at 3 - 25℃; for 19.5h; Solvent; Temperature; Reagent/catalyst; Inert atmosphere;3.8 g

2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3 ,4-tetrahydroisoquinoline-6-carboxylic acid

(S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoic acid

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Stage #1: 2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3 ,4-tetrahydroisoquinoline-6-carboxylic acid With [2-(1H-indol-3-yl)-ethyl]-methylamine; N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 40℃; for 2h; Inert atmosphere;
Stage #2: (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoic acid In tetrahydrofuran at 20 - 30℃;
92%
Stage #1: 2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3 ,4-tetrahydroisoquinoline-6-carboxylic acid With triethylamine In N,N-dimethyl-formamide at 28℃; for 0.166667h;
Stage #2: With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 5 - 8℃; for 2h;
Stage #3: (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoic acid In N,N-dimethyl-formamide at 8℃; for 1h;

(S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoic acid

3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl 2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylate

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Stage #1: (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoic acid; 3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl 2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylate With N-ethyl-N,N-diisopropylamine In acetonitrile at 40 - 45℃;
Stage #2: With hydrogenchloride In water at 0 - 5℃; for 1h; pH=5;
87%
With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20 - 45℃; for 4h;
77095-51-3

benzofuran-6-carboxylic acid

851785-70-1

(S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -10 - 20℃; Reagent/catalyst; Solvent; Temperature;83.8%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 10 - 20℃; for 1.5h;

C30H26Cl2N2O7S

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
With water; lithium hydroxide In methanol at 25 - 30℃; for 3h; Reagent/catalyst; Solvent;80%

C19H12Cl3NO3

(S)-2-amino-3-(3-(methylsulphonyl)phenyl)propanoic acid hydrochloride

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Stage #1: (S)-2-amino-3-(3-(methylsulphonyl)phenyl)propanoic acid hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Inert atmosphere;
Stage #2: C19H12Cl3NO3 In dichloromethane at 0 - 5℃; Temperature; Inert atmosphere;
77%
82278-73-7

(2S)-3-(3-bromophenyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 9 h / 100 °C
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C
3: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 0 °C
4: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
5: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
7: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: copper(l) iodide; caesium carbonate; L-proline; sodium methansulfinate / dimethyl sulfoxide / 9 h / 95 - 100 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap
3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C
4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
4.2: 18 h / 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
7.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 7 steps
1: copper(l) iodide; caesium carbonate; L-proline; sodium methansulfinate / dimethyl sulfoxide / 9 h / 95 - 100 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap
3: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C
4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
5: hydrogenchloride / water; 1,4-dioxane
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
7: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
1289646-76-9

(S)-2-((tert-butoxycarbonyl)amino)-3-((3-methylsulfonyl)phenyl)propanol

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C
2: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 0 °C
3: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
4: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
6: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap
2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C
3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
3.2: 18 h / 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
6.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 6 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap
2: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
4: hydrogenchloride / water; 1,4-dioxane
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
6: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 6 steps
1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 25 - 35 °C
1.2: 5 h / 25 - 45 °C
2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 25 - 35 °C
3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 25 - 35 °C
3.2: 5 h / 25 - 45 °C
4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 25 - 35 °C
5.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 25 - 35 °C
5.2: 5 h / 25 - 45 °C
6.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 25 - 35 °C
View Scheme
1289646-78-1

(S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-((3-methylsulfonyl)phenyl)propionate

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 0 °C
2: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
3: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
5: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C
2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
2.2: 18 h / 20 °C
3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
5.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 5 steps
1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C
2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
3: hydrogenchloride / water; 1,4-dioxane
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
5: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
1194550-59-8

(2S)-2-amino-3-(3-(methanesulfonyl)phenyl)propionic acid benzyl ester hydrochloride

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
2: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
4: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
1.2: 18 h / 20 °C
2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
4.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 4 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
2: hydrogenchloride / water; 1,4-dioxane
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
4: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
14046-52-7

N-(2-chloroethyl)-3,5-dichlorobenzylamine hydrochloride

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: aluminum (III) chloride / 185 °C
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / -78 - 20 °C
3.2: -78 - 20 °C
4.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
5.1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
7.1: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: aluminum (III) chloride; ammonium chloride / 185 °C
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
4.2: 18 h / 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
7.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 9 steps
1: aluminum (III) chloride; ammonium chloride / 185 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
3: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
4: hydrogenchloride / 1,4-dioxane
5: sodium hydrogencarbonate
6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
7: hydrogenchloride / water; 1,4-dioxane
8: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
9: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
1289646-72-5

C28H23Cl2N

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / -78 - 20 °C
1.2: -78 - 20 °C
2.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
3.1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
5.1: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
2.2: 18 h / 20 °C
3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
5.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 7 steps
1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
2: hydrogenchloride / 1,4-dioxane
3: sodium hydrogencarbonate
4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
5: hydrogenchloride / water; 1,4-dioxane
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
7: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
1194550-56-5

5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
2: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
4: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
1.2: 18 h / 20 °C
2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
4.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 6 steps
1: hydrogenchloride / 1,4-dioxane
2: sodium hydrogencarbonate
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
4: hydrogenchloride / water; 1,4-dioxane
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
6: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 3 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 h / 28 °C
2: sodium hydroxide / 1,4-dioxane; water / 2 h / 28 °C
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 1.5 h / 10 - 20 °C
View Scheme
1194550-63-4

C46H40Cl2N2O5S

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
3: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
3: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / 1,4-dioxane; water / 2 h / 28 °C
2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 1.5 h / 10 - 20 °C
View Scheme
1194550-65-6

benzyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-[3-(methylsulfonyl)phenyl]propanoate hydrochloride

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
2: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
10203-08-4

3,5-dichlorobenzaldehyde

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: methanol; sodium cyanoborohydride / 20 °C
2.1: aluminum (III) chloride / 185 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
4.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / -78 - 20 °C
4.2: -78 - 20 °C
5.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
6.1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
8.1: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 10 steps
1: sodium cyanoborohydride
2: aluminum (III) chloride; ammonium chloride / 185 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
4: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
5: hydrogenchloride / 1,4-dioxane
6: sodium hydrogencarbonate
7: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
8: hydrogenchloride / water; 1,4-dioxane
9: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
10: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 11 steps
1.1: ethanol / 2 h / 20 - 78 °C
2.1: sulfuric acid / dichloromethane / 7 h / 120 - 125 °C
2.2: 5 h / 0 - 50 °C / pH 12
3.1: platinum(IV) oxide / methanol / 0.17 h / 20 °C / Inert atmosphere
3.2: 25 h / 20 °C / 6464.52 Torr / Inert atmosphere
3.3: 0 - 40 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
5.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
6.1: hydrogenchloride / 1,4-dioxane
7.1: sodium hydrogencarbonate
8.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
9.1: hydrogenchloride / water; 1,4-dioxane
10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
11.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 8 steps
1.1: sodium cyanoborohydride
2.1: aluminum (III) chloride; ammonium chloride / 185 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
4.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
5.2: 18 h / 20 °C
6.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
8.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 9 steps
1.1: ethanol / 2 h / 20 - 78 °C
2.1: sulfuric acid / dichloromethane / 7 h / 120 - 125 °C
2.2: 5 h / 0 - 50 °C / pH 12
3.1: platinum(IV) oxide / methanol / 0.17 h / 20 °C / Inert atmosphere
3.2: 25 h / 20 °C / 6464.52 Torr / Inert atmosphere
3.3: 0 - 40 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
5.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
6.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
6.2: 18 h / 20 °C
7.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
9.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
89315-56-0

5,7-dichloro-1,2,3,4-tetrahydroisoquinoline

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / -78 - 20 °C
2.2: -78 - 20 °C
3.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
4.1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
6.1: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
3.2: 18 h / 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
6.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 8 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
2: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
3: hydrogenchloride / 1,4-dioxane
4: sodium hydrogencarbonate
5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
6: hydrogenchloride / water; 1,4-dioxane
7: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
8: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
82311-69-1

(S)-2-amino-3-(3-bromophenyl)propanoic acid

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: sodium hydrogencarbonate / 1,4-dioxane; water / 20 °C
2: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 9 h / 100 °C
3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C
4: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 0 °C
5: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
6: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
7: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C
8: palladium 10% on activated carbon; formic acid; triethylamine / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate / water; 1,4-dioxane
2.1: copper(l) iodide; caesium carbonate; L-proline; sodium methansulfinate / dimethyl sulfoxide / 9 h / 95 - 100 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap
4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C
5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
5.2: 18 h / 20 °C
6.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
8.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 8 steps
1: sodium hydrogencarbonate / water; 1,4-dioxane
2: copper(l) iodide; caesium carbonate; L-proline; sodium methansulfinate / dimethyl sulfoxide / 9 h / 95 - 100 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap
4: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C
5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
6: hydrogenchloride / water; 1,4-dioxane
7: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
8: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
1000210-73-0

(3,5-dichloro-benzylidene)-(2,2-diethoxy-ethyl)-amine

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: sulfuric acid / dichloromethane / 7 h / 120 - 125 °C
1.2: 5 h / 0 - 50 °C / pH 12
2.1: platinum(IV) oxide / methanol / 0.17 h / 20 °C / Inert atmosphere
2.2: 25 h / 20 °C / 6464.52 Torr / Inert atmosphere
2.3: 0 - 40 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
4.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
5.1: hydrogenchloride / 1,4-dioxane
6.1: sodium hydrogencarbonate
7.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
8.1: hydrogenchloride / water; 1,4-dioxane
9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
10.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 8 steps
1.1: sulfuric acid / dichloromethane / 7 h / 120 - 125 °C
1.2: 5 h / 0 - 50 °C / pH 12
2.1: platinum(IV) oxide / methanol / 0.17 h / 20 °C / Inert atmosphere
2.2: 25 h / 20 °C / 6464.52 Torr / Inert atmosphere
2.3: 0 - 40 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
4.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
5.2: 18 h / 20 °C
6.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
8.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
73075-58-8

5,7-dichloro isoquinoline

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: platinum(IV) oxide / methanol / 0.17 h / 20 °C / Inert atmosphere
1.2: 25 h / 20 °C / 6464.52 Torr / Inert atmosphere
1.3: 0 - 40 °C
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
4.2: 18 h / 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
7.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 9 steps
1.1: platinum(IV) oxide / methanol / 0.17 h / 20 °C / Inert atmosphere
1.2: 25 h / 20 °C / 6464.52 Torr / Inert atmosphere
1.3: 0 - 40 °C
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
4.1: hydrogenchloride / 1,4-dioxane
5.1: sodium hydrogencarbonate
6.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
7.1: hydrogenchloride / water; 1,4-dioxane
8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
9.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
14446-24-3

6-hydroxy-1,2,3,4-tetrahydroisoquinoline

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: N-chloro-succinimide / acetonitrile / 20 °C
2: sodium carbonate / methanol / 20 °C
3: pyridine / dichloromethane / 0.17 h / 0 - 2 °C
4: N-ethyl-N,N-diisopropylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 20 °C / Reflux
5: sodium hydroxide / methanol / Reflux
6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
7: hydrogenchloride / water; 1,4-dioxane
8: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
9: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
851784-78-6

C15H16Cl2F3NO5S

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 20 °C / Reflux
2: sodium hydroxide / methanol / Reflux
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
4: hydrogenchloride / water; 1,4-dioxane
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
6: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
851784-80-0

2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium hydroxide / methanol / Reflux
2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
3: hydrogenchloride / water; 1,4-dioxane
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
5: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 3 steps
1: lithium hydroxide; water / methanol / 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: lithium hydroxide; water / methanol / 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C
3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / -10 - 20 °C
View Scheme
851784-82-2

2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
2: hydrogenchloride / water; 1,4-dioxane
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
4: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / -10 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 25 - 35 °C
1.2: 2 h / 25 - 35 °C
2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / tetrahydrofuran / 0.5 h / 25 - 35 °C
2.2: 3 h / 25 - 35 °C
3.1: pyridine; lithium iodide hydrate / 100 - 105 °C
4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 25 - 35 °C
4.2: 2 h / 25 - 35 °C
View Scheme
1609545-55-2

C9H9Cl2NO*C7H8O3S

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: sodium carbonate / methanol / 20 °C
2: pyridine / dichloromethane / 0.17 h / 0 - 2 °C
3: N-ethyl-N,N-diisopropylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 20 °C / Reflux
4: sodium hydroxide / methanol / Reflux
5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
6: hydrogenchloride / water; 1,4-dioxane
7: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
8: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
851784-76-4

tert-butyl 5,7-dichloro-6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: pyridine / dichloromethane / 0.17 h / 0 - 2 °C
2: N-ethyl-N,N-diisopropylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 20 °C / Reflux
3: sodium hydroxide / methanol / Reflux
4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
5: hydrogenchloride / water; 1,4-dioxane
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
7: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 5 steps
1: pyridine / -20 - 20 °C
2: 1,3-bis-(diphenylphosphino)propane; N-ethyl-N,N-diisopropylamine; palladium diacetate / N,N-dimethyl acetamide / 20 °C
3: lithium hydroxide; water / methanol / 20 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1: pyridine / -20 - 20 °C
2: 1,3-bis-(diphenylphosphino)propane; N-ethyl-N,N-diisopropylamine; palladium diacetate / N,N-dimethyl acetamide / 20 °C
3: lithium hydroxide; water / methanol / 20 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C
5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / -10 - 20 °C
View Scheme
1194550-65-6

benzyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-[3-(methylsulfonyl)phenyl]propanoate hydrochloride

benzofuran-6-carboxylic chloride

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
2: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
6272-26-0

6-hydroxybenzofuran-3-one

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: triethylamine / acetone
2: sodium tetrahydroborate / methanol / 20 °C
3: hydrogenchloride; water / tetrahydrofuran / 28 °C / Inert atmosphere; Darkness
4: dichloromethane / 72 h
5: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave
6: lithium hydroxide; water / methanol
7: oxalyl dichloride / N,N-dimethyl-formamide / 5.5 h
8: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
9: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
73075-47-5

5,7-dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h
3.2: 18 h / 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
6.1: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 8 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 25 °C
2: n-butyllithium; N,N,N,N,-tetramethylethylenediamine
3: hydrogenchloride / 1,4-dioxane
4: sodium hydrogencarbonate
5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
6: hydrogenchloride / water; 1,4-dioxane
7: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C
8: triethylamine; palladium 10% on activated carbon; formic acid / tetrahydrofuran; methanol
View Scheme
1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

101-83-7

N-cyclohexyl-cyclohexanamine

lifitegrast dicyclohexylamine salt

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 24h;70%
1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

84674-32-8

1-isobutyric acid chloromethyl ester

1-(isobutyryloxy)ethyl (2S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 16h; Sealed tube;61%
80196-03-8

1-Chloroethyl methyl carbonate

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

1-((methoxycarbonyl)oxy)ethyl (2S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20 - 50℃; for 38h;42%
5912-58-3

1-chloroethyl acetate

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

1-acetoxyethyl (2S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 16h; Sealed tube;39%
1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

methyl (2R)-2-(((1-chloroethoxy)carbonyl)oxy)propanoate

1-(((((R)-1-methoxy-1-oxopropan-2-yl)oxy)carbonyl)oxy)ethyl (2S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 16h; Sealed tube;37%
1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

2-((((1-chloroethoxy)carbonyl)oxy)methyl)propane-1,3-diyl bis(2,2-dimethylpropanoate)

2-((8S)-10-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinolin-6-yl)-5-methyl-8-(3-(methylsulfonyl)benzyl)-3,7,10-trioxo-2,4,6-trioxa-9-azadecyl)propane-1,3-diyl bis(2,2-dimethylpropanoate)

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; Sealed tube;36%
58304-44-2

propanoic acid,1-chloroethyl ester

1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

C34H32Cl2N2O9S

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 18h; Inert atmosphere;35%
1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

2-((((1-chloroethoxy)carbonyl)oxy)methyl)propane-1,3-diyl diacetate

2-((8S)-10-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinolin-6-yl)-5-methyl-8-(3-(methylsulfonyl)benzyl)-3,7,10-trioxo-2,4,6-trioxa-9-azadecyl)propane-1,3-diyl diacetate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 72h;34%
1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

98298-66-9

1-(isopropoxycarbonyloxy)ethyl chloride

1-((isopropoxycarbonyl)oxy)ethyl (2S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 2h;24%
1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

40258-80-8

1-chloroethyl pivalate

1-(((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoyl)oxy)ethyl pivalate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 40℃; for 72h; Inert atmosphere;22%
1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

1-chloroethyl 5-((R)-1,2-dithiolan-3-yl)pentanoate

1-(((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoyl)oxy)ethyl 5-((R)-1,2-dithiolan-3-yl)pentanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 16h;4%
1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

50893-36-2

1-Chloroethyl ethyl carbonate

1-((ethoxycarbonyl)oxy)ethyl (2S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 40℃; for 20h; Inert atmosphere;3%
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    Lifitegrast CAS No.:1025967-78-5 Name: Lifitegrast Synonyms: N-[[2-(6-Benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-L-phenylalanine; SAR 1118

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  • Lifitegrast

  • Casno:

    1025967-78-5

    Lifitegrast

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 100.0-100.0/Kilogram

    HangYu Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. HangYu Chemical consis

    Zibo HangYu Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals

  •  Zibo Hangyu Import&Export Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-15988566987

    Address:Room1701, Tianxing Building,Licheng district, jinan, Shandong, China

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  • Lifitegrast

  • Casno:

    1025967-78-5

    Lifitegrast

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Chemvon Biotechnology Co. Ltd., established in the end of 2004, is a high-technology pharmaceutical and fine chemical company in R&D, manufacturing and sales of Lifitegrast . With the experience and specialization in technology of asymmetric sy

    Chemvon Biotechnology Co. Ltd is a high-technology pharmaceutical and fine chemical company, which is speciallized in RD, manufacturing and sales of APIs (Active Pharmaceutical I

  •  Chemvon Biotechnology Co. Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-21-58550039;86-21-31268550-8004

    Address:Suite B-10#, 6999 Chuansha Road, Pudong District, Shanghai 201202, China

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  • 1025967-78-5 	lifitegrast

  • Casno:

    1025967-78-5

    1025967-78-5 lifitegrast

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1000.0-1000.0/Kilogram

    Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

    Our company engages in Electronic chemicals such as OLED,Photoresist chemical,Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

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  • Best Quality Lifitegrast with good supplier

  • Casno:

    1025967-78-5

    Best Quality Lifitegrast with good supplier

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    Product name: Lifitegrast CAS No.:1025967-78-5 Molecule Formula:C29H24Cl2N2O7S Molecule Weight:615.48 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

    Siwei Development Group Ltd. is a reputed professional enterprise in China dedicated to the Amino Acids production and sales of fine chemical products.Over the years we have been m

  •  Siwei Development Group Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-82881840

    Address:Rm2-2-503 Zhongdingyuan, Xianghurenjia Wenyan Xiaoshan, Hangzhou China

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  • Lifitegrast

  • Casno:

    1025967-78-5

    Lifitegrast

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    how to confirm the product quality before placing orders you can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. you can send us your product specifications and request

    ShoChem Co. Ltd (Shochem) is mainly engaged in development of highly value-added pharmaceutical intermediates, fine chemicals, API synthesis, and the above process optimization. We

  •  Shochem(Shanghai) Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:021-50800795

    Address:No.1043, Halei Rd, Zhangjiang Hi-Tech Park, Shanghai, Postcode 201203, China

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  • Lifitegrast

  • Casno:

    1025967-78-5

    Lifitegrast

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    Why choice me: √1, We guarantee deeply analyze and demonstrate, purity more than 99% √ 2, Factory outlet with priority price & large stock. √ 3, Special magic vacuum safe package & safe shipping wa

    Zibo Dorne chemical technology co., LTD. Is a comprehensive chemical enterprise integrating r&d, production and sales. It is a leading manufacturer and supplier of chemical product

  •  Zibo Dorne chemical technology co. LTD

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-533-2362027

    Address:No. 416, 4th floor, zhongguancun science and technology city, no. 1, west 6th road, zhangdian district

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  • Lifitegrast

  • Casno:

    1025967-78-5

    Lifitegrast

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Our company advantages: 1 The highest quality with the competitive price. 2、 Professional human services. 3、 The fastest and safest delivery service. 4、Our old customers all around the world. 5、 The high purity products. 6、We have a suf

    Hangzhou Yunuo Chemical Co., Ltd. is located in Hangzhou City, China We are specialized in fine chemicals and basic chemical auxiliary materials, Organic compounds, rubber

  •  HANGZHOU YUNUO CHEMICAL CO.,LTD

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:0571-83715115

    Address:hangzhou

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  • lifitegrast

  • Casno:

    1025967-78-5

    lifitegrast

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    1, High quality with competitive price: 2, Fast and safe delivery 3.Excellent pre-sales and after-sales service 4. Well-trained and professional technologist and sales with rich experience in the field Appearance:see detailed specifications Sto

    Hangzhou Clap Technology Co., Ltd is a leading manufacturer and supplier of API, Pharma intermediates, organic and inorganic compounds, rare earth, pesticide, raw drugs, fine chemi

  •  HANGZHOU CLAP TECHNOLOGY CO,.LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-571-56972507

    Address:Room 4198,Floor 4,No.4,ShanXian Road XiaCheng District,HangZhou city,ZheJiang province,China

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  • Lifitegrast

  • Casno:

    1025967-78-5

    Lifitegrast

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

    Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in No

  •  Huarong Industrial Group Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-571-86758373

    Address:Room1707, 7Th Floor, Xin Chuanmei Industry Building , No.58 of Xintang Road, Jianggan District, Hangzhou, China.

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  • lifitegrast

  • Casno:

    1025967-78-5

    lifitegrast

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Hangzhou KieRaychem Co.,Ltd.is located in Yuhang District of Hangzhou City and specialized in the chemical product customization, development, sales, import and export. Current business is focused on fine chemicals, pharmaceutical materials and int

    Hangzhou KieRaychem Co.,Ltd.is located in Yuhang District of Hangzhou City and specialized in the chemical product customization, development, sales, import and export. Current bus

  •  Hangzhou KieRay Chem Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-15336573147

    Address:Room 260, Building 3, No. 76 Xingqiao North Road, Xingqiao Street, Yuhang District, Hangzhou City, Zhejiang Province, China

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  • lifitegrast

  • Casno:

    1025967-78-5

    lifitegrast

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:

    Triumph International Development Limilted is engaged in the API, pharmaceutical intermediates research and developmen.Adhering to the "customer first" business philosophy,we suppl

  •  Triumph International Development Limilted

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-536-7971999

    Address:Yinhai Road,Shouguang

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  • Lifitegrast/ supplier with competitive price in stock-Rechems

  • Casno:

    1025967-78-5

    Lifitegrast/ supplier with competitive price in stock-Rechems

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    1.Custom synthetic service could be provided and COA/HPLC/HNMR is available. 2.Professional synthesis laboratory and production base. 3.Strong synthesis team and service team.4.Professional data management system.5.We provide the professional test da

    Shanghai Rechem science Co., Ltd. is specialized in R&D of active drug molecules and customized chemical synthesis. Our company follows closely the industry trend, and the latest r

  •  Shanghai Rechem Science Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-21-51623867

    Address:Shanghai

       Inquiry Now

  • Lifitegrast/ 1025967-78-5

  • Casno:

    1025967-78-5

    Lifitegrast/ 1025967-78-5

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Zhengzhou Meitong Pharmaceutical Technology Co., Ltd. is a leading domestic Pharmaceutical intermediates; APIs; Impurities; Fine industry chemical manufacturer.Why Choose us:1: High purity and Competitive price2: Quality control.3: Packing as your re

    Zhengzhou Meitong Pharmaceutical Technology Co., Ltd. is a leading domestic medicine, biotechnology and cosmetics, health products research and development outsourcing services ent

  •  Zhengzhou Meitong Pharmaceutical Technology Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-0371-55216238

    Address:No. 1#1111,Guanzhouguoji,No.189, Yufeng Rd,Zhengzhou,Henan, China 450008

       Inquiry Now

  • lifitegrast

  • Casno:

    1025967-78-5

    lifitegrast

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

    Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in carbomer, Dibenzylamine,meglumine,lead acetate and other chemical raw materials and chemical reagents research

  •  Hebei Mojin Biotechnology Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:13231137666

    Address:room 1401,A building,Enjoy city,shijiazhuang city,hebei province,China

       Inquiry Now

  • Lifitegrast

  • Casno:

    1025967-78-5

    Lifitegrast

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    High quality / commercialize;Stable production capacity.Appearance:actual character Storage:Temperature controlled NMT 30℃ Package:As customer request Application:Used for Synthesis API and Research Transportation:Follow the MSDS

    Wit Pharma is a high-tech pharmaceutical company integrating R&D, production and sales, which is committed to the research and development of small molecule pharmaceutical intermed

  •  Nanjing Zhiyan Pharmaceutical Technology Co. Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-18602559219

    Address:Nanjing

       Inquiry Now

  • Lifitegrast Cas No: 1025967-78-5

  • Casno:

    1025967-78-5

    Lifitegrast Cas No: 1025967-78-5

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    factory Storage:Shading, sealed and preserved. Package:Grams, Kilograms Application:An organic synthetic intermediate used Transportation:According to customer request Port:Qingdao

    SHANDONG JILING CHEMICAL CO.,LTD, is founded in October 2006 with register capital of RMB 110 million. We are professional Optical Brightening Agent manufacturer, is a chemical en

  •  Shandong Jiling Chemical Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-135-73799911

    Address:58 North Industrial Road, Jinan, Shandong, China.

       Inquiry Now

  • lifitegrast

  • Casno:

    1025967-78-5

    lifitegrast

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

    GIHI CHEMICALS CO.,LIMITED, its former company is a small manufacturer who is specialized in the production of ester products which are used in the daily chemicals ,cosmetic produc

  •  GIHI CHEMICALS CO.,LIMITED

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:571-86217390

    Address:Huacai International Building,Sandun,Westlake District,Hangzhou 310030,Zhejiang,China

       Inquiry Now

  • Lifitegrast

  • Casno:

    1025967-78-5

    Lifitegrast

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

    As a member of TAIHO Group,Hubei Taiho Chemical Co.,Ltd,is a professional new-type chemicals enterprise combined into research and development,production and sales.We adhere to the

  •  Hubei Taiho Chemical Co.,LTD

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-18120399543

    Address:No. 49 taifeng Road,Qianjiang City,Hubei,China

       Inquiry Now

  • Lifitegrast with approved quality

  • Casno:

    1025967-78-5

    Lifitegrast with approved quality

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Wuhan Prominence Bio-technology Co., Ltd is a leading provider and manufacturer of pharmaceutical and chemical products. Mainly involves API, pharmaceutical intermediates peditides and natural extract etc. We are capable to supply you with any quanti

    Wuhan Prominence Bio-technology Co., Ltd is a leading provider and manufacturer of pharmaceutical and chemical products. Mainly involves API, pharmaceutical intermediates peptides

  •  Wuhan Prominence Bio-technology Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 18327075275

    Address:wuhan

       Inquiry Now

  • 99.78% Pharmaceutical Raw Materials Lifitegrast CAS NO.1025967-78-5

  • Casno:

    1025967-78-5

    99.78% Pharmaceutical Raw Materials Lifitegrast CAS NO.1025967-78-5

    Min.Order: 10 Gram

    FOB Price:  USD $ 1.0-2.0/Gram

    1,Best Quality: Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so

    Hubei Jusheng Technology Co., Ltd., is a large group corporation which engaged in the R&D and manufacture of chemicals, Pharmaceuticals and intermediates. We have earned ourselves

  •  Hubei Jusheng Technology Co., Ltd.,

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-18871490254

    Address:High-tech Industrial Park,Tianmen city,Hubei province.

       Inquiry Now

  • 99.78% Pharmaceutical Raw Materials Lifitegrast CAS NO.1025967-78-5

  • Casno:

    1025967-78-5

    99.78% Pharmaceutical Raw Materials Lifitegrast CAS NO.1025967-78-5

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    99.78% Pharmaceutical Raw Materials Lifitegrast CAS NO.1025967-78-5 Application:99.78% Pharmaceutical Raw Materials Lifitegrast CAS NO.1025967-78-5

    Hubei Xinrunde Chemical Co., Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredient(s)

  •  Hubei XinRunde Chemical Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8615102730682

    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

       Inquiry Now

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