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Basic Information
| CAS No.: | 10272-07-8 |
|---|---|
| Name: | 3,5-Dimethoxyaniline |
| Molecular Structure: | |
|
|
|
| Formula: | C8H11NO2 |
| Molecular Weight: | 153.181 |
| Synonyms: | 3,5-Dimethoxy-phenylamine;3,5-Dimethoxybenzeneamine;Benzenamine, 3,5-dimethoxy-;3，5-dimethoxy aniline;5-Aminoresorcinol dimethylether; |
| EINECS: | 233-616-5 |
| Density: | 1.096 g/cm3 |
| Melting Point: | 54-57 ºC |
| Boiling Point: | 178 ºC (20 mmHg) |
| Flash Point: | 135 ºC |
| Solubility: | insoluble in water |
| Appearance: | White crystal or Colorless liquid |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 22-36/37/38-20/21/22 |
| Safety: | 26-36-36/37/39-22 |
| Transport Information: | UN 2811 |
| PSA: | 44.48000 |
| LogP: | 1.86720 |
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Synthetic route
- 85862-68-6
1-azido-3,5-dimethoxybenzene
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; palladium In water for 1.5h; Inert atmosphere; | 99% |
| With sodium sulfide; water for 0.5h; Reflux; | 96% |
| With ammonium hydroxide at 90℃; for 0.5h; | 90% |
| With triethylamine; tris[tert-butyl]phosphonium tetrafluoroborate In tetrahydrofuran; water at 20℃; for 15h; Staudinger Azide Reduction; | 94 %Spectr. |
- 85657-94-9
N-(3,5-dimethoxyphenyl)-2,2,2-trifluoroacetamide
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With water; potassium carbonate In methanol for 20h; Ambient temperature; | 94% |
- 106018-88-6
2-Trimethylsilanyl-ethanesulfonic acid (3,5-dimethoxy-phenyl)-amide
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With cesium fluoride In N,N-dimethyl-formamide at 95℃; for 40h; | 93% |
- 7051-16-3
1-chloro-3,5-dimethoxybenzene
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation; | 93% |
| With ammonium hydroxide; potassium phosphate; copper(l) iodide; N1,N2-bis(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide In water; dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere; | 88% |
| With ammonium hydroxide; potassium phosphate; copper(l) iodide; N1,N2-bis(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide In dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere; Schlenk technique; | 88% |
- 79257-61-7
N-(3,5-dimethoxy-phenyl)-acetamide
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: N-(3,5-dimethoxy-phenyl)-acetamide With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.05h; Inert atmosphere; Stage #2: With water In tetrahydrofuran Inert atmosphere; chemoselective reaction; | 86% |
| With alkaline solution |
- 192182-54-0
3,5-dimethoxyphenylboronic acid
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 16h; | 82% |
- 20469-65-2
1-bromo-3,5-dimethoxybenzene
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 1-bromo-3,5-dimethoxybenzene With magnesium In tetrahydrofuran Inert atmosphere; Stage #2: With C10H17NO In tetrahydrofuran; toluene at -78℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water; toluene Inert atmosphere; | 78% |
| With ammonium hydroxide; copper(l) iodide; N,N'-bis(3,5-dimethoxyphenyl)cyclopentane-1,1-dicarboxamide; caesium carbonate In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; Sealed tube; | 68% |
| With ammonia; sodium; ferric nitrate |
- 25245-27-6
1-iodo-3,5-dimethoxybenzene
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; copper(l) iodide; N,N'-bis(3,5-dimethoxyphenyl)cyclopentane-1,1-dicarboxamide; caesium carbonate In dimethyl sulfoxide at 20℃; for 24h; Inert atmosphere; Sealed tube; | 75% |
- 500-99-2
3,5-dimethoxyphenol
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3,5-dimethoxyphenol With Nonafluorobutanesulfonyl fluoride; tris(trimethylsilyl)amine; potassium hexamethylsilazane In tetrahydrofuran at 60℃; for 5h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; for 0.0833333h; pH=3 - 4; Reagent/catalyst; Solvent; | 75% |
- 1132-21-4
3,5-dimethoxybenzoic acid
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3,5-dimethoxybenzoic acid With diphenylphosphoranyl azide; triethylamine In toluene at 80℃; Stage #2: With sodium hydroxide In tetrahydrofuran; toluene at 20℃; for 2h; | 43% |
| Stage #1: 3,5-dimethoxybenzoic acid With diphenylphosphoranyl azide; triethylamine In toluene at 80℃; Stage #2: With sodium hydroxide In tetrahydrofuran for 2h; | 43% |
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3,5-Dimethoxyaniline
Chemistry
Formula：C8H11NO2
Molecular Weight：153.18
Appearance：Beige crystals
Solubility in water：Soluble
Melting Point：66 – 68
Boiling Point：303
3,5-Dimethoxyaniline`s Synonyms：BENZENAMINE, 3,5-DIMETHOXY-;3,5-DIMETHOXYANILINE;3,5-DIMETHOXYPHENYLAMINE;5-AMINORESORCINOL DIMETHYL ESTER;5-AMINORESORCINOL DIMETHYL ETHER;AKOS 91392;3,5-dimethoxy-benzenamin;3,5-dimethoxy-Benzenamine
Molecular Structure:
Molecular Weight：153.18
Appearance：Beige crystals
Solubility in water：Soluble
Melting Point：66 – 68
Boiling Point：303
3,5-Dimethoxyaniline`s Synonyms：BENZENAMINE, 3,5-DIMETHOXY-;3,5-DIMETHOXYANILINE;3,5-DIMETHOXYPHENYLAMINE;5-AMINORESORCINOL DIMETHYL ESTER;5-AMINORESORCINOL DIMETHYL ETHER;AKOS 91392;3,5-dimethoxy-benzenamin;3,5-dimethoxy-Benzenamine
Molecular Structure:
Toxicity Data With Reference
3,5-Dimethoxyaniline may cause gastrointestinal irritation with nausea, vomiting and diarrhea. respiratory tract irritation and skin or eyes irritation. The toxicological properties of this substance have not been fully investigated
Consensus Reports
Stability:Stable under normal temperatures and pressures
First Aid Measures:
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical ai
Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Storage：Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling：Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
First Aid Measures:
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical ai
Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Storage：Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling：Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Safety Profile
Hazard Codes: Xn, Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-36/37/39-22
WGK Germany: 3
Hazard Note: Irritant
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
S 22 Do not breathe dust.
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-36/37/39-22
WGK Germany: 3
Hazard Note: Irritant
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
S 22 Do not breathe dust.
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
Specification
Flash Point: 142
Fire Fighting: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam.
Personal Protection: Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Fire Fighting: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam.
Personal Protection: Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.