CAS No.103-80-0,phenylacetyl chloride Suppliers,MSDS download

Products Categories

Pharmaceutical (52)
Others (19)
Organic Chemicals (18)
Reagent (4)
Agrochemicals (4)
Basic Inorganic Chemicals (1)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	103-80-0
Name:	phenylacetyl chloride
Article Data:	166
Cas Database

Formula:	C₈H₇ClO
Molecular Weight:	154.596
Synonyms:	Benzeneacetyl chloride;Acetylchloride, phenyl- (6CI,7CI,8CI);2-Phenylacetyl chloride;2-Phenylethanoylchloride;Phenacetyl chloride;Phenylacetic acid chloride;Phenylaceticchloride;a-Phenylacetyl chloride;
EINECS:	203-146-5
Density:	1.16 g/cm³
Melting Point:	91oC
Boiling Point:	218.7 °C at 760 mmHg
Flash Point:	90 °C
Appearance:	Colourless liquid
Hazard Symbols:	C
Risk Codes:	34-37-14
Safety:	26-36/37/39-45-25-27
Transport Information:	UN 2577 8/PG 2
PSA:	17.07000
LogP:	1.99450

Synthetic route

: 103-82-2
phenylacetic acid

: 103-80-0
phenylacetyl chloride

Conditions

Conditions	Yield
With thionyl chloride In dichloromethane	100%
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 23℃;	100%
With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	100%

: 383865-57-4
4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine

A: N-(4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-2-phenyl-acetamide

B: 103-80-0
phenylacetyl chloride

Conditions

Conditions	Yield
	A 37% B n/a

: 103-82-2
phenylacetic acid

: 79-37-8
oxalyl dichloride

: 103-80-0
phenylacetyl chloride

: 79-37-8
oxalyl dichloride

: 114-70-5
sodium phenylacetate

: 103-80-0
phenylacetyl chloride

Conditions

Conditions	Yield
With benzene

: 937611-56-8
4-chloro-1,3,4-triphenyl-butan-2-one

A: 588-59-0
stilbene

B: 103-80-0
phenylacetyl chloride

: 5437-84-3
phenyl-acetic acid hydrazide; hydrochloride

: 103-80-0
phenylacetyl chloride

Conditions

Conditions	Yield
With Nitroethane; chlorine

: 114-70-5
sodium phenylacetate

A: 1555-80-2
phenylacetic anhydride

B: 103-80-0
phenylacetyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride

: 79-37-8
oxalyl dichloride

: 108-88-3
toluene

: 94-36-0
dibenzoyl peroxide

: 103-80-0
phenylacetyl chloride

...Expand

: 103-82-2
phenylacetic acid

: 79-37-8
oxalyl dichloride

: 71-43-2
benzene

A: 1555-80-2
phenylacetic anhydride

B: 103-80-0
phenylacetyl chloride

...Expand

: 140-29-4
phenylacetonitrile

: 103-80-0
phenylacetyl chloride

Conditions

Conditions	Yield
With thionyl chloride; sulfuric acid Multistep reaction;

Raw Materials

140-29-4

103-82-2

114-70-5

88211-07-8

629-01-6

5437-84-3

108-88-3

79-37-8

Downstream Products

Total:89 Page 1 of 3 1 2 3 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 103-80-0

Specification

The Phenylacetyl chloride with CAS registry number of 103-80-0 is also known as Phenylacetic acid chloride. The IUPAC name is 2-Phenylacetyl chloride. It belongs to product categories of Pharmaceutical Intermediates; Acid Halides; Carbonyl Compounds; Organic Building Blocks. Its EINECS registry number is 203-146-5. In addition, the formula is C₈H₇ClO and the molecular weight is 154.60. This chemical is a colourless liquid that soluble in water and ether. It may destroy living tissue on contact and should be sealed in ventilated, cool, dry place away from oxidants, alkali, alcohols and water. What's more, this chemical is used as intermediates for pharmaceuticals, pesticides, spices and organic synthesis.

Physical properties about Phenylacetyl chloride are: (1)ACD/LogP: 1.628; (2)ACD/LogD (pH 5.5): 1.63; (3)ACD/LogD (pH 7.4): 1.63; (4)ACD/BCF (pH 5.5): 10.17; (5)ACD/BCF (pH 7.4): 10.17; (6)ACD/KOC (pH 5.5): 183.07; (7)ACD/KOC (pH 7.4): 183.07; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.535; (11)Molar Refractivity: 40.681 cm³; (12)Molar Volume: 130.755 cm³; (13)Polarizability: 16.127 10-24cm³; (14)Surface Tension: 39.2970008850098 dyne/cm; (15)Density: 1.182 g/cm³; (16)Flash Point: 89.971 °C; (17)Enthalpy of Vaporization: 45.51 kJ/mol; (18)Boiling Point: 218.704 °C at 760 mmHg; (19)Vapour Pressure: 0.123999997973442 mmHg at 25°C

Preparation of Phenylacetyl chloride: it is prepared by reaction of benzeneacetic acid with thionyl chloride. The reaction releases sulfur dioxide and hydrogen chloride gas at room temperature. When reaction is complete, the reaction mixture is heated to 30-40 °C for 25 hours and benzene is added. After steaming volatile matter, product is obtained by collecting distillate at 55-57 °C (0.133kPa). The yield is about 80-85%.

Uses of Phenylacetyl chloride: it is used to produce 1,2-diphenyl-ethanone by reaction with iodobenzene. The reaction occurs with reagent NBu₄BF₄, catalyst NiBr₂bpy and solvent acetonitrile with ambient temperature. The yield is about 35%.

Phenylacetyl chloride is used to produce 1,2-diphenyl-ethanone by reaction with iodobenzene.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to respiratory system and reacts violently with water. It can cause burns. During using it, wear suitable protective clothing, gloves and eye/face protection. Avoid contact with eyes. After using it, take off immediately all contaminated clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If accident happens or you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1=CC=C(C=C1)CC(=O)Cl
2. InChI: InChI=1S/C8H7ClO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2
3. InChIKey: VMZCDNSFRSVYKQ-UHFFFAOYSA-N