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| CAS No.: | 103129-82-4 |
|---|---|
| Name: | (S)-Amlodipine |
| Article Data: | 25 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C20H25ClN2O5 |
| Molecular Weight: | 408.882 |
| Synonyms: | 3,5-Pyridinedicarboxylicacid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-,3-ethyl 5-methyl ester, (S)-;(-)-Amlodipine;(S)-(-)-Amlodipine;Levamlodipine;Levoamlodipine;Lodien;l-Amlodipine; |
| EINECS: | 1592732-453-0 |
| Density: | 1.227 g/cm3 |
| Melting Point: | 102-104°C |
| Boiling Point: | 527.2 °C at 760 mmHg |
| Flash Point: | 272.6 °C |
| Appearance: | white crystal powder |
| PSA: | 99.88000 |
| LogP: | 3.29540 |
- 103131-69-7Kinetensin
- 10313-60-7Benzeneacetyl chloride,3,4-dimethoxy-
- 103139-94-23H-Imidazo[4,5-f]quinoxalin-2-amine,3,5,8-trimethyl-
- 103-14-0Phenol,4-[(phenylmethyl)amino]-
- 103140-12-1Acetonitrile,2-(3,5-dichlorophenoxy)-
- 103141-09-91H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-
- 103146-25-4Benzonitrile,4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-
- 103146-26-5Benzonitrile,4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-,hydrobromide (1:1)
- 10314-98-41,4-Piperidinedicarboxylicacid, 1-(phenylmethyl) ester
- 10314-99-51-Piperidinecarboxylicacid,4-(chlorocarbonyl)-,phenylmethyl ester
- 103129-82-4
amlodipine
| Conditions | Yield |
|---|---|
| With sodium hydroxide In dichloromethane; water at 20℃; for 0.666667h; | 93.9% |
- 103129-82-4
amlodipine
| Conditions | Yield |
|---|---|
| With sodium hydroxide In dichloromethane; water at 20℃; for 0.5h; | 93% |
- 103129-82-4
amlodipine
| Conditions | Yield |
|---|---|
| With ammonia; water In dichloromethane for 0.5h; Product distribution / selectivity; | 92% |
- 88150-42-9
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
- 103129-82-4
amlodipine
| Conditions | Yield |
|---|---|
| Stage #1: 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine With D-(+)-camphoric acid In isopropyl alcohol at 20℃; for 12.5h; Stage #2: With sodium hydroxide In dichloromethane; water for 1h; Reagent/catalyst; | 90.5% |
| With D-tartaric acid In dimethyl sulfoxide; acetone at 20 - 60℃; for 1.5h; Reagent/catalyst; Solvent; | 45.2% |
| Stage #1: 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine With L-Tartaric acid In ISOPROPYLAMIDE at 5℃; for 2h; Resolution of racemate; Stage #2: With sodium hydroxide In dichloromethane; water for 0.666667h; | n/a |
| Multi-step reaction with 2 steps 1: water; iso-butanol / 1 h / 50 °C 2: sodium hydroxide / dichloromethane; water / pH 9 View Scheme |
- 103129-82-4
amlodipine
| Conditions | Yield |
|---|---|
| With sodium hydroxide In dichloromethane; water pH=9; | 90% |
| With sodium hydroxide In dichloromethane; water pH=9; | 90% |
- 103129-82-4
amlodipine
| Conditions | Yield |
|---|---|
| With ammonia; water In dichloromethane for 0.5h; Product distribution / selectivity; | 82% |
- 147-71-7
D-tartaric acid
- 88150-42-9
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
- 68-12-2, 33513-42-7
N,N-dimethyl-formamide
B
- 103129-82-4
amlodipine
| Conditions | Yield |
|---|---|
| In water at 20℃; for 4.5h; Product distribution / selectivity; | A 78.38% B n/a |
- 103129-82-4
amlodipine
| Conditions | Yield |
|---|---|
| With sodium hydrogencarbonate In dichloromethane; water at 5℃; for 0.333333h; | 69% |
- 143191-87-1
(-)-2-<<2-<(tert-butoxycarbonyl)amino>ethoxy>-methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
- 103129-82-4
amlodipine
| Conditions | Yield |
|---|---|
| With hydrogenchloride In 1,4-dioxane; acetonitrile for 1h; | 64% |
- 125711-60-6
2-<(2-azidoethoxy)methyl>-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine
- 103129-82-4
amlodipine
| Conditions | Yield |
|---|---|
| With hydrogen; Lindlar's catalyst In ethanol under 775.7 Torr; Yield given; | |
| With sodium tetrahydroborate; nickel dichloride In ethanol Ambient temperature; Yield given; |
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Chemistry
Product Name: Levamlodipine besylate (CAS NO.103129-82-4)
Molecular Formula: C20H25N2O5Cl
Molecular Weight: 408.88g/mol
Index of Refraction: 1.546
Molar Refractivity: 105.419 cm3
Molar Volume: 333.02 cm3
Surface Tension: 44.445 dyne/cm
Density: 1.228 g/cm3
Flash Point: 272.617 °C
Enthalpy of Vaporization: 80.168 kJ/mol
Product Categories: Pharmaceutical material and intermeidates
Uses
Levamlodipine besylate (CAS NO.103129-82-4) is mainly used as anti-cardiovascular drugs.
Analytical Methods
Specification
Levamlodipine besylate (CAS NO.103129-82-4) is also named as (S)-Amlodipine;3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)- ; 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (S)- and so on.