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CAS No.: | 10347-81-6 |
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Name: | Maprotiline hydrochloride |
Molecular Structure: | |
Formula: | C20H23N.HCl |
Molecular Weight: | 313.87 |
Synonyms: | 9,10-Ethanoanthracene-9(10H)-propanamine,N-methyl-, hydrochloride (9CI);9,10-Ethanoanthracene-9(10H)-propylamine,N-methyl-, hydrochloride (7CI,8CI);9,10-Dihydro-9-(3-methylaminopropyl)-9,10-ethanoanthracene hydrochloride;9-[g-(Methylamino)propyl]-9,10-dihydro-9,10-ethanoanthracenehydrochloride;CIBA 34,276Ba;CIBA 34276 hydrochloride;Ladiomil;Ludiomil;Psymion;9,10-Ethanoanthracene-9(10H)-propanamine,N-methyl-, hydrochloride (1:1); |
EINECS: | 233-758-8 |
Melting Point: | 230-232 °C |
Boiling Point: | 399.6 °C at 760 mmHg |
Flash Point: | 187.7 °C |
Solubility: | 50 mg/mL in water |
Appearance: | Crystalline solid |
Hazard Symbols: | Xn |
Risk Codes: | 22 |
Safety: | 7-16-36/37-45 |
Transport Information: | UN 3249 |
PSA: | 12.03000 |
LogP: | 5.40430 |
maprotiline hydrochloride
p-benzoquinone
Conditions | Yield |
---|---|
In dichloromethane for 24h; Ambient temperature; | 90% |
maprotiline hydrochloride
Desmethylmaprotiline
Conditions | Yield |
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With human liver microsomes; NADPH-generating system In phosphate buffer at 37℃; for 0.25h; pH=7.4; Enzyme kinetics; Further Variations:; Solvents; |
maprotiline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / CH2Cl2 / 24 h / Ambient temperature 2: CH2Cl2 / Ambient temperature View Scheme |
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1. Introduction of Maprotiline hydrochloride
Maprotiline hydrochloride is one kind of crystalline solid. Its chemical name is N-methyl-9,10-ethanoanthracene-9(10H)-propylamine hydrochloride. Besides, Maprotiline hydrochloride belongs to Active Pharmaceutical Ingredients;Chemical Amines;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor. In addition, the Classification Code of it is Antidepressant; Drug / Therapeutic Agent; Human Data; Reproductive Effect. And its solubility in H2O is 50 mg/mL.
2. Properties of Maprotiline hydrochloride
Physical properties about Maprotiline hydrochloride are:
(1)Flash Point: 187.7 °C; (2)Enthalpy of Vaporization: 65.04 kJ/mol; (3)Boiling Point: 399.6 °C at 760 mmHg; (4)Vapour Pressure: 1.35E-06 mmHg at 25°C; (5)Melting point: 230-232°C; (6)H-Bond Donor: 2; (7)H-Bond Acceptor: 1; (8)Rotatable Bond Count: 4; (9)Exact Mass: 313.159727; (10)MonoIsotopic Mass: 313.159727; (11)Topological Polar Surface Area: 12; (12)Heavy Atom Count: 22; (13)Formal Charge: 0; (14)Complexity: 339; (15)Isotope Atom Count: 0; (16)Defined Atom Stereocenter Count: 0; (17)Undefined Atom Stereocenter Count: 0; (18)Defined Bond Stereocenter Count: 0; (19)Undefined Bond Stereocenter Count: 0; (20)Covalently-Bonded Unit Count: 2.
3. Structure Descriptors of Maprotiline hydrochloride
(1)InChI: InChI=1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H
(2)InChIKey: NZDMFGKECODQRY-UHFFFAOYSA-N
(3)Canonical SMILES : CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.Cl
(4)Smiles: c1cc2c(cc1)C1CCC2(CCCNC)c2ccccc12.Cl
4. Toxicity of Maprotiline hydrochloride
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
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cat | LDLo | intravenous | 30mg/kg (30mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. |
cat | LDLo | oral | > 300mg/kg (300mg/kg) | Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. | |
child | TDLo | oral | 12mg/kg (12mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | American Journal of Emergency Medicine. Vol. 6, Pg. 247, 1988. |
dog | LDLo | intravenous | 20mg/kg (20mg/kg) | Bollettino Chimico Farmaceutico. Vol. 112, Pg. 782, 1973. | |
dog | LDLo | oral | 20mg/kg (20mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. |
human | TDLo | oral | 17mg/kg (17mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | British Medical Journal. Vol. 1, Pg. 1573, 1977. |
man | TDLo | oral | 490ug/kg (0.49mg/kg) | BEHAVIORAL: SLEEP | Journal of Clinical Psychiatry. Vol. 47, Pg. 210, 1986. |
man | TDLo | oral | 391mg/kg/1Y-I (391mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: INCONTINENCE | Postgraduate Medical Journal. Vol. 55, Pg. 742, 1979. |
mouse | LD50 | intraperitoneal | 125mg/kg (125mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 229, Pg. 163, 1977. | |
mouse | LD50 | intravenous | 31mg/kg (31mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. |
mouse | LD50 | oral | 480mg/kg (480mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1, Pg. 207, 1975. |
mouse | LD50 | subcutaneous | 310mg/kg (310mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1, Pg. 207, 1975. |
rabbit | LDLo | intravenous | 20mg/kg (20mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. |
rabbit | LDLo | oral | > 1gm/kg (1000mg/kg) | Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. | |
rat | LD50 | intraperitoneal | 72mg/kg (72mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. |
rat | LD50 | intravenous | 35mg/kg (35mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1, Pg. 207, 1975. |
rat | LD50 | oral | 760mg/kg (760mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. |
rat | LD50 | subcutaneous | 170mg/kg (170mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. |
women | LDLo | oral | 90mg/kg (90mg/kg) | BEHAVIORAL: COMA | Journal of Analytical Toxicology. Vol. 6, Pg. 199, 1982. |
women | TDLo | oral | 7mg/kg/1W-I (7mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Journal of Clinical Pyschopharmacology. Vol. 3, Pg. 264, 1983. |
women | TDLo | oral | 20mg/kg (20mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | American Journal of Emergency Medicine. Vol. 2, Pg. 144, 1984. |
women | TDLo | oral | 63mg/kg/6W-I (63mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: INCONTINENCE | Postgraduate Medical Journal. Vol. 55, Pg. 742, 1979. |
women | TDLo | oral | 75mg/kg (75mg/kg) | BEHAVIORAL: COMA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Intensive Care Medicine. Vol. 11, Pg. 220, 1985. |