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CAS No.: | 103475-41-8 |
---|---|
Name: | Tepoxalin |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C20H20ClN3O3 |
Molecular Weight: | 385.85 |
Synonyms: | ORF 20485;RWJ 20485;3-[1-(4-Methoxyphenyl)-5-(4-chlorophenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide; |
Density: | 1.27 g/cm3 |
Melting Point: | 124-126° |
Boiling Point: | 572.991 °C at 760 mmHg |
Flash Point: | 300.334 °C |
PSA: | 67.59000 |
LogP: | 3.98150 |
4-methoxyphenylhydrazine hydrochloride
6-(4-chlorophenyl)-4,6-dioxo-N-hydroxy-N-methylhexanamide
A
tepoxalin
B
3-<3-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-pyrazolyl>-N-hydroxy-N-methylpropanamide
Conditions | Yield |
---|---|
With sodium carbonate In ethanol for 3h; Heating; | A 70% B 10% |
oxalyl dichloride
N-methylhydroxyamine hydrochloride
water
3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]propionic acid
N,N-dimethyl-formamide
tepoxalin
Conditions | Yield |
---|---|
In tetrahydrofuran | 65% |
N-methylhydroxyamine hydrochloride
3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride
tepoxalin
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 1h; Ambient temperature; Yield given; |
4,6-dioxo-6-(4-chlorophenyl)hexanoic acid
tepoxalin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 81 percent / Ac2O / 0.33 h / Heating 2: 87 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 3: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 81 percent / Ac2O / 0.33 h / Heating 2: Et3N / CH2Cl2 / 0.5 h / Ambient temperature 3: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 81 percent / Ac2O / 0.33 h / Heating 2: 16 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 3: 60 percent Turnov. / CH2Cl2 / 16 h 4: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 81 percent / Ac2O / 0.33 h / Heating 2: 3 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 3: 74 percent / 10percent HCl / 1 h 4: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 94 percent / NEt3 / methanol / 6 h / Ambient temperature 2: oxalyl chloride / CH2Cl2 / 3 h / Ambient temperature 3: NEt3 / CH2Cl2 / 1 h / Ambient temperature View Scheme |
5-<1-(4-chlorophenyl)-1-oxoethanylidene>-3,4-dihydrofuran-2-one
tepoxalin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 87 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 2: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 0.5 h / Ambient temperature 2: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 16 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 2: 60 percent Turnov. / CH2Cl2 / 16 h 3: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 3 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 2: 74 percent / 10percent HCl / 1 h 3: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme |
O-(N-methylamino)-6-(4-chlorophenyl)-4,6-dioxohexanoate
tepoxalin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 60 percent Turnov. / CH2Cl2 / 16 h 2: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme |
6-(4-chlorophenyl)-4-(N-hydroxy-N-methylamino)-6-oxo-N-hydroxy-N-methyl-4-hexenamide
tepoxalin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 74 percent / 10percent HCl / 1 h 2: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme |
4-methoxyphenylhydrazine hydrochloride
tepoxalin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 94 percent / NEt3 / methanol / 6 h / Ambient temperature 2: oxalyl chloride / CH2Cl2 / 3 h / Ambient temperature 3: NEt3 / CH2Cl2 / 1 h / Ambient temperature View Scheme |
3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]propionic acid
tepoxalin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: oxalyl chloride / CH2Cl2 / 3 h / Ambient temperature 2: NEt3 / CH2Cl2 / 1 h / Ambient temperature View Scheme |
Empirical Formula: C20H20ClN3O3
Molecular Weight: 385.8441
Nominal Mass: 385 Da
Average Mass: 385.8441 Da
Monoisotopic Mass: 385.119319 Da
Index of Refraction: 1.61
Molar Refractivity: 105.36 cm3
Molar Volume: 303.8 cm3
Surface Tension: 46.7 dyne/cm
Density: 1.26 g/cm3
Flash Point: 300.3 °C
Enthalpy of Vaporization: 90.34 kJ/mol
Boiling Point: 573 °C at 760 mmHg
Vapour Pressure: 5.72E-14 mmHg at 25°C
Structure of Tepoxalin (CAS NO.103475-41-8):
IUPAC Name: 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
Canonical SMILES: CN(C(=O)CCC1=NN(C(=C1)C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)OC)O
InChI: InChI=1S/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3
InChIKey: XYKWNRUXCOIMFZ-UHFFFAOYSA-N
Product Category of Tepoxalin (CAS NO.103475-41-8): Drug / Therapeutic Agent;Antirheumatic Agents;Analgesics
Tepoxalin (CAS NO.103475-41-8) is primarily used to reduce inflammation and relief of pain caused by musculoskeletal disorders such as hip dysplasia and arthritis, and is a nonsteroidal anti-inflammatory drug approved for veterinary use (in dogs) in the United States and the European Union.
Tepoxalin , its cas register number is 103475-41-8. It also can be called Tepoxalinum ; 3-(5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl)-N-hydroxy-N-methylpropanamide ; and 5-(4-Chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide .