CAS No.103475-41-8,Tepoxalin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	103475-41-8
Name:	Tepoxalin
Article Data:	6

Formula:	C₂₀H₂₀ClN₃O₃
Molecular Weight:	385.85
Synonyms:	ORF 20485;RWJ 20485;3-[1-(4-Methoxyphenyl)-5-(4-chlorophenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide;
Density:	1.27 g/cm³
Melting Point:	124-126°
Boiling Point:	572.991 °C at 760 mmHg
Flash Point:	300.334 °C
PSA:	67.59000
LogP:	3.98150

Synthetic route

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 142791-64-8
6-(4-chlorophenyl)-4,6-dioxo-N-hydroxy-N-methylhexanamide

A: 103475-41-8
tepoxalin

B: 149065-93-0
3-<3-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-pyrazolyl>-N-hydroxy-N-methylpropanamide

Conditions

Conditions	Yield
With sodium carbonate In ethanol for 3h; Heating;	A 70% B 10%

...Expand

: 79-37-8
oxalyl dichloride

triethylamine (Et3 N): triethylamine (Et3 N)

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 7732-18-5
water

: 114150-42-4
3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]propionic acid

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 103475-41-8
tepoxalin

Conditions

Conditions	Yield
In tetrahydrofuran	65%

...Expand

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 114151-49-4
3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride

: 103475-41-8
tepoxalin

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1h; Ambient temperature; Yield given;

: 111881-78-8
4,6-dioxo-6-(4-chlorophenyl)hexanoic acid

: 103475-41-8
tepoxalin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 81 percent / Ac2O / 0.33 h / Heating 2: 87 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 3: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 81 percent / Ac2O / 0.33 h / Heating 2: Et3N / CH2Cl2 / 0.5 h / Ambient temperature 3: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme
Multi-step reaction with 4 steps 1: 81 percent / Ac2O / 0.33 h / Heating 2: 16 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 3: 60 percent Turnov. / CH2Cl2 / 16 h 4: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme
Multi-step reaction with 4 steps 1: 81 percent / Ac2O / 0.33 h / Heating 2: 3 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 3: 74 percent / 10percent HCl / 1 h 4: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 94 percent / NEt3 / methanol / 6 h / Ambient temperature 2: oxalyl chloride / CH2Cl2 / 3 h / Ambient temperature 3: NEt3 / CH2Cl2 / 1 h / Ambient temperature View Scheme

: 142791-63-7
5-<1-(4-chlorophenyl)-1-oxoethanylidene>-3,4-dihydrofuran-2-one

: 103475-41-8
tepoxalin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 87 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 2: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 0.5 h / Ambient temperature 2: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 16 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 2: 60 percent Turnov. / CH2Cl2 / 16 h 3: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 3 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 2: 74 percent / 10percent HCl / 1 h 3: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme

: 144192-63-2
O-(N-methylamino)-6-(4-chlorophenyl)-4,6-dioxohexanoate

: 103475-41-8
tepoxalin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 60 percent Turnov. / CH2Cl2 / 16 h 2: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme

: 144192-64-3
6-(4-chlorophenyl)-4-(N-hydroxy-N-methylamino)-6-oxo-N-hydroxy-N-methyl-4-hexenamide

: 103475-41-8
tepoxalin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 74 percent / 10percent HCl / 1 h 2: 70 percent / Na2CO3 / ethanol / 3 h / Heating View Scheme

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 103475-41-8
tepoxalin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 94 percent / NEt3 / methanol / 6 h / Ambient temperature 2: oxalyl chloride / CH2Cl2 / 3 h / Ambient temperature 3: NEt3 / CH2Cl2 / 1 h / Ambient temperature View Scheme

: 114150-42-4
3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]propionic acid

: 103475-41-8
tepoxalin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: oxalyl chloride / CH2Cl2 / 3 h / Ambient temperature 2: NEt3 / CH2Cl2 / 1 h / Ambient temperature View Scheme

hydroxamic acid: hydroxamic acid

: 7732-18-5
water

: 103475-41-8
tepoxalin

: 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-methylpropanamide sodium salt monohydrate

Conditions

Conditions	Yield
	97%

...Expand

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Chemistry

Empirical Formula: C₂₀H₂₀ClN₃O₃
Molecular Weight: 385.8441
Nominal Mass: 385 Da
Average Mass: 385.8441 Da
Monoisotopic Mass: 385.119319 Da
Index of Refraction: 1.61
Molar Refractivity: 105.36 cm³
Molar Volume: 303.8 cm³
Surface Tension: 46.7 dyne/cm
Density: 1.26 g/cm³
Flash Point: 300.3 °C
Enthalpy of Vaporization: 90.34 kJ/mol
Boiling Point: 573 °C at 760 mmHg
Vapour Pressure: 5.72E-14 mmHg at 25°C
Structure of Tepoxalin (CAS NO.103475-41-8):

IUPAC Name: 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
Canonical SMILES: CN(C(=O)CCC1=NN(C(=C1)C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)OC)O
InChI: InChI=1S/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3
InChIKey: XYKWNRUXCOIMFZ-UHFFFAOYSA-N
Product Category of Tepoxalin (CAS NO.103475-41-8): Drug / Therapeutic Agent;Antirheumatic Agents;Analgesics

Uses

Tepoxalin (CAS NO.103475-41-8) is primarily used to reduce inflammation and relief of pain caused by musculoskeletal disorders such as hip dysplasia and arthritis, and is a nonsteroidal anti-inflammatory drug approved for veterinary use (in dogs) in the United States and the European Union.

Specification

Tepoxalin , its cas register number is 103475-41-8. It also can be called Tepoxalinum ; 3-(5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl)-N-hydroxy-N-methylpropanamide ; and 5-(4-Chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide .