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1035-69-4

Basic Information
CAS No.: 1035-69-4
Name: NSC44826
Article Data: 35
Molecular Structure:
Molecular Structure of 1035-69-4 (NSC44826)
Formula: C19H24 O2
Molecular Weight: 284.398
Synonyms: 9(11)-Dehydroandrostenedione;NSC 44826
Density: 1.14g/cm3
Melting Point: 202-204 °C
Boiling Point: 448.5°Cat760mmHg
Flash Point: 167.2°C
PSA: 34.14000
LogP: 4.00750
Synthetic route
560-62-3, 23015-99-8

9-alpha-hydroxyandrost-4-ene-3,17-dione

1035-69-4

androst-4,9(11)-dien-3,17-dione

Conditions
ConditionsYield
In water; benzene97.5%
In water; benzene97.5%
With sulfuric acid; acetic acid In dichloromethane; water Reflux;95%
10184-70-0

Anecortave

1035-69-4

androst-4,9(11)-dien-3,17-dione

Conditions
ConditionsYield
With sodium bismuthate87%
With manganese(IV) oxide In chloroform for 4h; Heating;72.6%
4972-29-6

benzenesulphinyl chloride

9α-hydroxyandrostenedione

1035-69-4

androst-4,9(11)-dien-3,17-dione

Conditions
ConditionsYield
With concentrated aqueous hydrochloric acid; p-TSA; sodium hydrogencarbonate In pyridine; water; benzene83.7%
149884-29-7

androst-5,9(11)-dien-3,17-dione-3,17-di-ethylene ketal

1035-69-4

androst-4,9(11)-dien-3,17-dione

Conditions
ConditionsYield
With acetic acid In water at 110℃; for 0.333333h;71%
With acetic acid Heating;70%
382-44-5

(8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione

1035-69-4

androst-4,9(11)-dien-3,17-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid; orthoformic acid triethyl ester In benzene Heating;50%
With N,N'-Thionyldiimidazole In tetrahydrofuran for 0.5h; Ambient temperature;45%
With hydrogenchloride; diethyl ether; benzene
382-44-5

(8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione

A

1035-69-4

androst-4,9(11)-dien-3,17-dione

B

96436-74-7

6β-hydroxy-4,9(11)-androstadiene-3,17-dione

Conditions
ConditionsYield
With ethanol; oxygen; toluene-4-sulfonic acid; orthoformic acid triethyl ester Product distribution; Irradiation;A 35%
B 12%
With ethanol; oxygen; toluene-4-sulfonic acid; orthoformic acid triethyl ester 1.) 1 h, reflux; 2.) irradiation, ethanol, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
With ethanol; oxygen; toluene-4-sulfonic acid; orthoformic acid triethyl ester 1.) 1 h, reflux, benzene; 2.) irradiation in ethanol, 3 h.; Yield given. Multistep reaction. Yields of byproduct given;
50-23-7

HYDROCORTISONE

1035-69-4

androst-4,9(11)-dien-3,17-dione

Conditions
ConditionsYield
With bithmuth(III) triflate hydrate In nitromethane at 100℃;34%
Multi-step reaction with 3 steps
1: 52 percent / MnO2
2: 48 percent / p-TsOH, triethyl orthoformate / benzene / 8 h / Heating
3: 70 percent / aq. AcOH / Heating
View Scheme
2398-99-4

hydroxy-17β androstadiene-4,9(11) one-3,7

1035-69-4

androst-4,9(11)-dien-3,17-dione

Conditions
ConditionsYield
With chromium(VI) oxide; acetic acid Oxidation;
560-62-3, 23015-99-8

9-alpha-hydroxyandrost-4-ene-3,17-dione

A

1035-69-4

androst-4,9(11)-dien-3,17-dione

B

4,8(9)-androstadiene-3,17-dione

Conditions
ConditionsYield
With N,N'-Thionyldiimidazole In tetrahydrofuran for 1.5h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
28838-93-9

(5R,8S,10R,13S,14S)-5-Hydroxy-10,13-dimethyl-1,4,5,6,7,8,10,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione

1035-69-4

androst-4,9(11)-dien-3,17-dione

Conditions
ConditionsYield
With hydrogenchloride In methanol Heating;
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