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107-07-3

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Basic Information
CAS No.: 107-07-3
Name: Ethanol, 2-chloro-
Molecular Structure:
Molecular Structure of 107-07-3 (Ethanol, 2-chloro-)
Formula: C2H5 Cl O
Molecular Weight: 80.52
Synonyms: 1-Chloro-2-hydroxyethane;2-Chloro-1-ethanol; 2-Chloro-1-hydroxyethane; 2-Chloroethanol; 2-Chloroethylalcohol; 2-Hydroxyethyl chloride; Chloroethanol; Ethene chlorohydrin;Ethylchlorohydrin; Ethylene chlorhydrin; Ethylene chlorohydrin; Glycolchlorohydrin; Glycol monochlorohydrin; NSC 122289; b-Chloroethanol; b-Chloroethyl alcohol; b-Hydroxyethyl chloride
EINECS: 203-459-7
Density: 1.201
Melting Point: -63 ºC
Boiling Point: 129 ºC
Flash Point: 55 ºC
Solubility: MISCIBLE
Appearance: clear, colorless liquid.
Hazard Symbols:
Risk Codes: R26/27/28   
Safety: A poison by ingestion, inhalation, skin contact, intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic to humans by inhalation. It can affect the nervous system, liver, spleen, and lungs. An experimental teratogen. Mutation data reported. A severe eye and mild skin irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. Violent reaction with chlorosulfonic acid, ethylene diamine, sodium hydroxide. Reacts with water or steam to produce toxic and corrosive fumes. Potentially violent reaction with oxidizing materials. When heated to decomposition it emits highly toxic fumes of Cl and phosgene. See also CHLORINATED HYDROCARBONS, ALIPHATIC.

Analytical Methods:

   

For occupational chemical analysis use NIOSH: Ethylene Chlorohydrin, 2513.

Transport Information: UN 1135
PSA: 20.23000
LogP: 0.21750
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Chemistry

MF: C2H5ClO
MW: 80.51
EINECS: 203-459-7
ETHYLENE CHLOROHYDRIN,it's melting point is about -63 °C ,boiling point is 129 °C(lit.),density is 1.201 g/mL at 25 °C(lit.).It is colorless liquid with a pleasant ether-like odor. It is miscible with water.

Uses

ETHYLENE CHLOROHYDRIN is a building block in the production of pharmaceuticals, biocides and plasticizers. It is also used for manufacture of thiodiglycol. It is a solvent for cellulose acetate and ethyl cellulose, textile printing dyes, extraction of pine lignin, in dewaxing, refining of rosin, and the cleaning of machines.
Several dyes are prepared by the alkylation of aniline derivatives with chloroethanol.

Production

ETHYLENE CHLOROHYDRIN is produced by treating ethylene with hypochlorous acid:
CH2=CH2 + HOCl → HOCH2CH2Cl

Toxicity Data With Reference

1.   

skn-rbt 200 mg/2H MLD

   TXAPA9    Toxicology and Applied Pharmacology. 16 (1970),382.
2.   

eye-rbt 2 mg SEV

   AJOPAA    American Journal of Ophthalmology. 29 (1946),1363.
3.   

eye-rbt 33 mg MOD

   TXAPA9    Toxicology and Applied Pharmacology. 16 (1970),382.
4.   

eye-rbt 9 mg/6H MOD

   BUYRAI    Bulletin of Parenteral Drug Association. 31 (1977),25.
5.   

sln-asn 74,500 µmol/L

   MUREAV    Mutation Research. 138 (1984),33.
6.   

oms-rat:lvr 12 g/L

   JACTDZ    Journal of the American College of Toxicology. 1 (3)(1982),37.
7.   

ihl-man LCLo:305 ppm/2H

   JIHTAB    Journal of Industrial Hygiene and Toxicology. 26 (1944),277.
8.   

orl-rat LD50:71 mg/kg

   HYSAAV    Hygiene and Sanitation: English Translation of Gigiena Sanitariya. 36 (1971),376.
9.   

ihl-rat LC50:290 mg/m3

   HYSAAV    Hygiene and Sanitation: English Translation of Gigiena Sanitariya. 26 (1971),376.
10.   

ipr-rat LD50:58 mg/kg

   TXAPA9    Toxicology and Applied Pharmacology. 21 (1972),454.


RTECS :KK0875000

ETHYLENE CHLOROHYDRIN is toxic with an LD50 of 89 mg/kg in rats.

Consensus Reports

NTP Carcinogenesis Studies (dermal); No Evidence: mouse, rat NTPTR*    National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-275 ,1985. ; Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program. EPA Extremely Hazardous Substances List.

Safety Profile

A poison by ingestion, inhalation, skin contact, intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic to humans by inhalation. It can affect the nervous system, liver, spleen, and lungs. An experimental teratogen. Mutation data reported. A severe eye and mild skin irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. Violent reaction with chlorosulfonic acid, ethylene diamine, sodium hydroxide. Reacts with water or steam to produce toxic and corrosive fumes. Potentially violent reaction with oxidizing materials. When heated to decomposition it emits highly toxic fumes of Cl and phosgene. See also CHLORINATED HYDROCARBONS, ALIPHATIC.



Like most organochlorine compounds, ETHYLENE CHLOROHYDRIN combusts to yield hydrogen chloride and phosgene.
Hazard Codes:  T+,T,F
Risk Statements : 26/27/28-39/23/24/25-11
Safety Statements : 28-45-7/9-28A-36/37-16
RIDADR  :UN 1135 6.1/PG 1
 
WGK Germany  3

Standards and Recommendations

OSHA PEL: CL 1 ppm (skin)
ACGIH TLV: CL 1 ppm (skin); Not Classifiable as a Human Carcinogen
DFG MAK: 1 ppm (3.3 mg/m2)
DOT Classification:  6.1; Label: Poison

Analytical Methods

For occupational chemical analysis use NIOSH: Ethylene Chlorohydrin, 2513.

Specification

 
Other names of ETHYLENE CHLOROHYDRIN :2-chloroethyl alcohol, ethylene chlorohydrin, 2-chloro-1-ethanol, 2-monochloroethanol,glycol chlorohydrin,  2-hydroxyethyl chloride,  β-hydroxyethyl chloride, β-chloroethanol,chloroethanol,ethylchlorhydrin,  δ-chloroethanol, ethylene chlorohydrin, glycol monochlorohydrin.