107-15-3

Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.

OSHA PEL: TWA 10 ppm
ACGIH TLV: TWA 10 ppm; Not Classifiable as a Human Carcinogen
DFG MAK: 10 ppm (25 mg/m³)
DOT Classification:  8; Label: Corrosive, Flammable Liquid

1,2-ETHANEDIAMINE's Analytical Methods:For occupational chemical analysis use OSHA: #ID-60 or NIOSH: Ethylenediamine, 2540.

The Ethylenediamine is colorless liquid with an ammonia-like odor. It belongs to the categories of (1)Pharmaceutical Intermediates ; (2)alpha,omega-Alkanediamines ; (3)alpha,omega-Bifunctional Alkanes ; (4)Biochemistry ; (5)Reagents for Oligosaccharide Synthesis. With cas registry number of 107-15-3, it also has other registry numbers including 8030-24-8 and 85404-18-8. Its IUPAC name and systematic name are the same which is called ethane-1,2-diamine with SMILES: NCCN. The superlist name about this chemical are (1)1,2-Diaminoethane ; (2) Ethylenediamine ; (3) Ethylenediamine ; (4) Ethylenediamine [UN1604] [Corrosive] ; (5) UN1604 .

Physical properties about this chemical are: (1) # of Rule of 5 Violations: 0 ; (2) ACD/LogD (pH 5.5): -5.97 ; (3) ACD/LogD (pH 7.4): -4.53 ; (4) ACD/BCF (pH 5.5): 1 ; (5) ACD/BCF (pH 7.4): 1 ; (6) ACD/KOC (pH 5.5): 1 ; (7) ACD/KOC (pH 7.4): 1 ; (8) #H bond acceptors: 2 ; (9) #H bond donors: 4 ; (10) #Freely Rotating Bonds: 3 ; (11) Index of Refraction: 1.446 ; (12) Molar Refractivity: 18.38 cm³ ; (13) Molar Volume: 68.9 cm³ ; (14) Surface Tension: 36.8 dyne/cm ; (15) Density: 0.872 g/cm³ ; (16) Flash Point: 33.9 °C ; (17) Enthalpy of Vaporization: 37.98 kJ/mol; (18) Refractive index: n20/D 1.4565(lit.); (19) Sensitive: Air Sensitive; (20) Boiling Point: 119.7 °C at 760 mmHg ; (21) Vapour Pressure: 15.8 mmHg at 25°C.

Preparation of Ethylenediamine : this chemical is prepared by the reaction of ammonia and 1,2-dichloroethane . This reaction can give the mixture of ethylenediamine and the linear polyamines.
ClCH₂CH₂Cl + 4 NH₃ → H₂NCH₂CH₂NH₂ + 2 NH₄Cl

Uses of Ethylenediamine : this compound is mainly used for production of many chemicals. Here is a example.

This reaction will use the solvent water and AcOK / AcOH buffer, pH = 5. The yield is about 30%.

When you are using this chemical, please be cautious about it as the following:
A human poison by inhalation. Experimental poison by inhalation, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion and skin contact. Experimental reproductive effects. Corrosive. A severe skin and eye irritant. An allergen and sensitizer. Mutation data reported. Flammable liquid when exposed to heat, flame, or oxidizers. Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, allyl chloride, CS₂, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, HCl, mesityl oxide, HNO₃, oleum, AgClO₄, H₂SO₄, β-propiolactone, or vinyl acetate. To fight fire, use CO₂, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NO_x and NH₃.

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	100mg/kg (100mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.
guinea pig	LD50	oral	470mg/kg (470mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES	Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
human	TCLo	inhalation	200ppm (200ppm)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS	AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 223, 1954.
mouse	LC50	inhalation	300mg/m3 (300mg/m3)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 66, 1982.
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)		Chimica Therapeutica. Vol. 4, Pg. 136, 1969.
mouse	LD50	oral	1gm/kg (1000mg/kg)	BEHAVIORAL: ATAXIA	Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (1), Pg. 38, 1997.
rabbit	LD50	skin	730uL/kg (0.73mL/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rabbit	LDLo	subcutaneous	500mg/kg (500mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.
rat	LCLo	inhalation	4000ppm/8H (4000ppm)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat	LD50	intraperitoneal	76mg/kg (76mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 454, 1972.
rat	LD50	oral	1200mg/kg (1200mg/kg)	BEHAVIORAL: ATAXIA	Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (1), Pg. 38, 1997.
rat	LD50	subcutaneous	300mg/kg (300mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 66, 1982.