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1070-11-7

Basic Information
CAS No.: 1070-11-7
Name: Ethambutol dihydrochloride
Molecular Structure:
Molecular Structure of 1070-11-7 (Ethambutol dihydrochloride)
Formula: C10H24N2O2.2(HCl)
Molecular Weight: 277.235
Synonyms: (+)-2,2-(Ethylenediimino)-di-1-butanol dihydrochloride;Prestwick_208;(2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol dihydrochloride;1-Butanol, 2,2-(1,2-ethanediyldiimino)bis-, dihydrochloride, (R-(R*,R*))- (9CI);Ethambutol hydrochloride;CL 40881;(S-(R*,R*))-2,2-(Ethylenediimino)dibutan-1-ol dihydrochloride;1-Butanol,2,2'-(1,2-ethanediyldiimino)bis-,dihydrochloride,(2S,2'S)-;Ethambutol hydrochloride (JP14/USP);Myambutol;1-Butanol, 2,2-(1,2-ethanediyldiimino)bis-, dihydrochloride, (S-(R*,R*))-;Ethambutol hydrochloride [USAN:JAN];(2R)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol dihydrochloride;Myambutol (TN);Ethambutol HCl;
EINECS: 213-970-7
Melting Point: 198-200 °C
Boiling Point: 345.3 °C at 760 mmHg
Flash Point: 113.7 °C
Solubility: Slightly soluble in water
Appearance: white powder
Hazard Symbols: ToxicT,IrritantXi
Risk Codes: 61-36/37/38
Safety: 53-22-36/37/39-45-36/37-26
PSA: 64.52000
LogP: 2.09320
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    Product name: Ethambutol HCL CAS No.: 1070-11-7 Molecule Formula:C10H25ClN2O2 Molecule Weight:240.77 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

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    Product Name: Ethambutol dihydrochloride CAS: 1070-11-7 MF: C10H24N2O2.2ClH MW: 277.23 EINECS: 213-970-7 Mol File: 1070-11-7.mol Ethambutol dihydrochloride Structure Ethambutol dihydrochloride Chemical Properties Melting point

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Chemistry

IUPAC Name: (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol
dihydrochloride
The MF of ETHAMBUTOL DIHYDROCHLORIDE(1070-11-7): C10H24N2O2·2(HCl)
The MW of ETHAMBUTOL DIHYDROCHLORIDE(1070-11-7): 277.23
EINECS: 213-970-7
Density: 0.987 g/cm3 
Flash Point: 113.7 °C
Boiling Point: 345.3 °C at 760 mmHg 
Index of Refraction: 1.477
Synonyms: ETHAMBUTOL HCL; Ethambutol Hydrochloride; 2,2'-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride; [S-(R*,R*)]-2,2'-(Ethylenediimino)dibutan-1-ol dihydrochloride
The Structure of ETHAMBUTOL DIHYDROCHLORIDE(1070-11-7):

Uses

ETHAMBUTOL DIHYDROCHLORIDE(1070-11-7) is used as antibacterial.

Toxicity Data With Reference

1.   

mnt-mus-orl 50 mg/kg

   IRLCDZ    IRCS Medical Science: Library Compendium. 10 (1982),135.
2.   

spm-mus-orl 12,500 µg/kg

   IRLCDZ    IRCS Medical Science: Library Compendium. 10 (1982),135.
3.   

orl-man TDLo:45 mg/kg/3D-I:EYE

   BJDCAT    British Journal of Diseases of the Chest. 80 (1986),288.
4.   

orl-man TDLo:46 mg/kg/3D-I:EYE

   PGMJAO    Postgraduate Medical Journal. 61 (1985),811.
5.   

unr-wmn TDLo:720 mg/kg/48D:EYE

   ANOPB5    Annals of Ophthalmology. 2 (1970),578.
6.   

orl-rat LD50:6800 mg/kg

   OYYAA2    Oyo Yakuri. Pharmacometrics. 2 (1968),70.
7.   

ipr-rat LD50:1200 mg/kg

   OYYAA2    Oyo Yakuri. Pharmacometrics. 2 (1968),70.
8.   

ivn-rat LD50:300 mg/kg

   OYYAA2    Oyo Yakuri. Pharmacometrics. 2 (1968),70.
9.   

orl-mus LD50:8900 mg/kg

   OYYAA2    Oyo Yakuri. Pharmacometrics. 2 (1968),70.
10.   

scu-mus LD50:1800 mg/kg

   OYYAA2    Oyo Yakuri. Pharmacometrics. 2 (1968),70.
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Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous routes. Mildly toxic by ingestion. Human systemic effects: constriction of the pupil, visual field changes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl. See also AMINES.
Hazard Codes: T: Toxic;
Risk Statements: R61: May cause harm to the unborn child 
Safety Statements:
S53: Avoid exposure - obtain special instruction before use 
S22: Do not breathe dust 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)