CAS No.1075-89-4,3,3-Tetramethyleneglutarimide Suppliers

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Basic Information

Molecular Structure:
CAS No.:	1075-89-4
Name:	3,3-Tetramethyleneglutarimide
Article Data:	5

Formula:	C₉H₁₃NO₂
Molecular Weight:	167.208
Synonyms:	1,1-Cyclopentanediacetimide(6CI,7CI,8CI);8-Azaspiro[4.5]decane-7,9-dione;3-Spirocyclopentaneglutarimide;4,4-Tetramethyleneglutarimide;NSC 400092;b-Spirocyclopentaneglutarimide;
EINECS:	427-770-4
Density:	1.17 g/cm³
Melting Point:	153-155 °C
Boiling Point:	350.7 °C at 760 mmHg
Flash Point:	162.6 °C
Appearance:	white to off-white crystalline powder
Hazard Symbols:	T+
Risk Codes:	28
Safety:	36/37/39-45
PSA:	46.17000
LogP:	1.31220

Synthetic route

: 5662-95-3
3,3-tetramethylene glutaric anhydride

: 1075-89-4
tetramethylene glutarimide

Conditions

Conditions	Yield
With ammonium hydroxide In tetrahydrofuran at 190℃;	92%

ammonium salt of/the/ cyclopentane-diacetic acid-(1.1): ammonium salt of/the/ cyclopentane-diacetic acid-(1.1)

: 1075-89-4
tetramethylene glutarimide

cyclopentane-dimalonic acid-(1.1)-monoamide: cyclopentane-dimalonic acid-(1.1)-monoamide

: 1075-89-4
tetramethylene glutarimide

Conditions

Conditions	Yield
ueber den Schmelzpunkt;

: 1075-89-4
tetramethylene glutarimide

: 106-96-7
propargyl bromide

: 25032-23-9
8-Propargyl-8-azaspiro<4.5>decane-7,9-dione

Conditions

Conditions	Yield
With potassium carbonate In acetone for 10h; Heating;	100%
With potassium carbonate In acetone Heating;	100%

: 110-52-1
1,4-dibromo-butane

: 20980-22-7
N-(2-pyridinyl)piperazine

: 1075-89-4
tetramethylene glutarimide

: 36505-84-7
BUSPIRONE

Conditions

Conditions	Yield
With potassium carbonate; benzyltriethylammonium bromide Product distribution; 1.) xylene, reflux, 3 h, 2.) reflux, 5 h; other imides and catalysts, variation of reaction time, also in toluene; also 1-(2-quinolinyl)piperazine;	97%
With potassium carbonate; benzyltriethylammonium bromide 1.) xylene, reflux, 3 h, 2.) reflux, 5 h; Yield given. Multistep reaction;

...Expand

: 29882-07-3
4-chlorobutanal dimethyl acetal

: 1075-89-4
tetramethylene glutarimide

: 1359159-58-2
8-(4,4-dimethoxybutyl)-8-azaspiro[4.5]decane-7,9-dione

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In dimethyl sulfoxide at 80℃; for 4h;	96%

: 1075-89-4
tetramethylene glutarimide

: 100-39-0
benzyl bromide

: 77261-38-2
8-benzyl-8-azaspiro[4.5]decane-7,9-dione

Conditions

Conditions	Yield
Stage #1: tetramethylene glutarimide With potassium carbonate for 1h; Stage #2: benzyl bromide In acetone for 2h; Reflux; Inert atmosphere;	96%

: 24424-99-5
di-tert-butyl dicarbonate

: 1075-89-4
tetramethylene glutarimide

: 854280-06-1
8-(tert-butoxycarbonyl)-7,9-dioxo-8-azaspiro[4.5]decane

Conditions

Conditions	Yield
With dmap In acetonitrile at 20℃; for 15h;	95%

: 1075-89-4
tetramethylene glutarimide

: 180-44-9
3-azaspiro[5.5]undecane

Conditions

Conditions	Yield
In tetrahydrofuran	94%

: 1075-89-4
tetramethylene glutarimide

: 98-88-4
benzoyl chloride

: 8-benzoyl-8-azaspiro[4.5]decane-7,9-dione

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 15h; Schlenk technique; Inert atmosphere;	94%

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Specification

The 3,3-Tetramethyleneglutarimide, with the CAS registry number 1075-89-4, is also known as 8-Azaspiro[4,5]decane-7,9-dione. It belongs to the product categories of Building Blocks. Its EINECS registry number is 427-770-4. This chemical's molecular formula is C₉H₁₃NO₂ and molecular weight is 167.21. Its IUPAC name is called 8-azaspiro[4.5]decane-7,9-dione. The product should be sealed and stored in cool and dry place.

Physical properties of 3,3-Tetramethyleneglutarimide: (1)ACD/LogP: 1.47; (2)ACD/LogD (pH 5.5): 1.47; (3)ACD/LogD (pH 7.4): 1.47; (4)ACD/BCF (pH 5.5): 7.76; (5)ACD/BCF (pH 7.4): 7.76; (6)ACD/KOC (pH 5.5): 150.92; (7)ACD/KOC (pH 7.4): 150.91; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)Index of Refraction: 1.523; (11)Molar Refractivity: 43.52 cm³; (12)Molar Volume: 142.4 cm³; (13)Surface Tension: 43.7 dyne/cm; (14)Density: 1.17 g/cm³; (15)Flash Point: 162.6 °C; (16)Enthalpy of Vaporization: 59.53 kJ/mol; (17)Boiling Point: 350.7 °C at 760 mmHg; (18)Vapour Pressure: 4.31E-05 mmHg at 25°C.

Uses of 3,3-Tetramethyleneglutarimide: it can be used to produce 8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione at temperature of 60 °C. This reaction will need reagent KI, K₂CO₃ and solvent acetonitrile with reaction time of 6 hours. The yield is about 69%.

When you are using this chemical, please be cautious about it as the following:
This chemical that at very low levels can cause damage to health. It is very toxic if swallowed. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1CCC2(C1)CC(=O)NC(=O)C2
(2)InChI: InChI=1S/C9H13NO2/c11-7-5-9(3-1-2-4-9)6-8(12)10-7/h1-6H2,(H,10,11,12)
(3)InChIKey: YRTHJMQKDCXPAY-UHFFFAOYSA-N