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CAS No.: | 1076-22-8 |
---|---|
Name: | 2,6-Dihydroxy-3-methylpurine |
Article Data: | 49 |
Molecular Structure: | |
Formula: | C6H6N4O2 |
Molecular Weight: | 166.139 |
Synonyms: | 1H-Purine-2,6-dione,3,7-dihydro-3-methyl- (9CI);Xanthine, 3-methyl- (6CI,7CI,8CI);3-Methyl-3,7-dihydro-1H-purine-2,6-dione;3-Methyl-3,7-dihydropurine-2,6-dione;3-Methylxanthine;NSC 515466; |
EINECS: | 214-058-1 |
Density: | 1.54 g/cm3 |
Melting Point: | >300 °C |
Boiling Point: | 322.4oC at 760 mmHg |
Flash Point: | 148.8oC |
Solubility: | Insoluble in water. |
Appearance: | white to cream solid |
Hazard Symbols: | Xn, T+ |
Risk Codes: | 22-26/27/28 |
Safety: | 22-24/25 |
PSA: | 83.54000 |
LogP: | -1.05010 |
4-(N-methylamino)-1H-imidazole-5-carboxamide
3-methylxanthine
Conditions | Yield |
---|---|
With formic acid; perchloric acid adsorbed on silica gel In ethanol at 20℃; for 0.333333h; Solvent; | 95.12% |
Conditions | Yield |
---|---|
Stage #1: formic acid; 5,6-diamino-1-methyluracil In water at 105℃; for 3h; Stage #2: With sodium hydroxide In water at 105℃; for 1h; | 94.1% |
Stage #1: formic acid; 5,6-diamino-1-methyluracil In water for 3h; Reflux; Inert atmosphere; Stage #2: With sodium hydroxide In water for 1h; Reflux; Inert atmosphere; | 80% |
Stage #1: formic acid; 5,6-diamino-1-methyluracil In water for 3h; Reflux; Inert atmosphere; Stage #2: With sodium hydroxide In water at 20℃; for 1h; Inert atmosphere; Reflux; | 78% |
7-benzyl-3-methylxanthine
3-methylxanthine
Conditions | Yield |
---|---|
With 20 % Pd(OH)2/C; hydrogen In acetic acid; ethyl acetate at 90℃; under 75007.5 Torr; for 0.416667h; H-Cube reactor; | 90% |
Conditions | Yield |
---|---|
With hydrogenchloride In water for 0.5h; Ambient temperature; | 84% |
With hydrogenchloride In water at 25℃; Rate constant; hydrolytic cleavage of the glycosidic bond in several HCl solutions; |
1-methyl-2,4-dioxo-5,6-diaminopyrimidine hydrochloride
orthoformic acid triethyl ester
3-methylxanthine
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 70℃; for 3.5h; | 53% |
Conditions | Yield |
---|---|
With acetic acid nachfolgenden Behandeln mit Eisenchlorid; |
5,6-diamino-1-methyluracil
formamide
3-methylxanthine
Conditions | Yield |
---|---|
With palladium on activated charcoal; formic acid; isopropyl alcohol Erwaermen des Reaktionsprodukts mit wss.NaOH; | |
Multi-step reaction with 3 steps 1: 98 percent / H2 / 10percent Pd/C / H2O / 3750.3 Torr / Ambient temperature 2: 96 percent / 10percent Pd/C / 39.9 °C 3: NaOH View Scheme | |
Multi-step reaction with 2 steps 1: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C 2: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min View Scheme |
5-acetylamino-6-amino-1-methyl-1H-pyrimidine-2,4-dione
formamide
3-methylxanthine
(1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amidosulfuric acid
formamide
3-methylxanthine
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IUPAC Name: 2,6-Dihydroxy-3-methylpurine
The MF of 2,6-Dihydroxy-3-methylpurine (1076-22-8) is C6H6N4O2.
The MW of 2,6-Dihydroxy-3-methylpurine (1076-22-8) is 166.14.
Synonyms of 2,6-Dihydroxy-3-methylpurine (1076-22-8): 3-Methylxanthine ; 1H-purine-2,6-dione, 3,7-dihydro-3-methyl- ; 3-Methyl-3,7-dihydro-1H-purin-2,6-dion
Product Categories: Pyridines,Purines and Pteredines;Heterocycles series
Form: White to yellow powder or solid
Index of Refraction: 1.626
EINECS: 214-058-1
Density: 1.539 g/ml
Melting Point: >300 °C
Storage temp: 2-8°C
The MF of 2,6-Dihydroxy-3-methylpurine (1076-22-8) is used for propentofylline (cognition enhancer).
1. | ipr-mus LD50:1300 mg/kg | FATOAO Farmakologiya i Toksikologiya (Moscow). 46 (5)(1983),104. | ||
2. | ivn-dog LDLo:300 mg/kg | AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. 43 (1900),305. | ||
3. | ivn-rbt LDLo:500 mg/kg | AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. 43 (1900),305. |
Poison by intravenous route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
Safety information of 2,6-Dihydroxy-3-methylpurine (1076-22-8):
Hazard Codes Xn,T+
Risk Statements
22 Harmful if swallowed
26/27/28 Very Toxic by inhalation, in contact with skin and if swallowed
Safety Statements
22 Do not breathe dust
24/25 Avoid contact with skin and eyes
WGK Germany 1
RTECS ZD8750000