CAS No.110-21-4,BIUREA Suppliers

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Basic Information

Molecular Structure:
CAS No.:	110-21-4
Name:	BIUREA
Article Data:	120

Formula:	C2H6 N4 O2
Molecular Weight:	118.095
Synonyms:	Biurea(6CI,7CI,8CI);1,1'-Hydrazobis(formamide);Bicarbamamide;Bicarbamimidic acid;Cellmic 142;Diurea;FE 823;HDCA;Hydradicarbonamide;Hydrazine,1,2-bis(aminocarbonyl)-;Hydrazine-N,N'-bis(carboxamide);Hydrazinedicarboxylicacid diamide;Hydrazocarbonamide;Hydrazodicarbamide;Hydrazodicarbonamide;Hydrazodicarboxamide;KBH 30;LDA;LDA (fire retardant);N,N'-Biscarbamoylhydrazine;NSC 1897;S 3176;Ureidourea;
EINECS:	203-747-2
Density:	1.461g/cm³
Melting Point:	247-250 °C
Boiling Point:	°Cat760mmHg
Flash Point:	°C
Appearance:	WHITE POWDER
Risk Codes:	36/37/38
Safety:	Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_x.
PSA:	110.24000
LogP:	0.42040

Synthetic route

: 123-77-3
Azodicarboxamid

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
With hydrazine hydrate In acetonitrile at 20℃; for 1.5h;	98%
With hydrogen sulfide; water beim Kochen;
With hydrogenchloride beim Kochen;
With water; sodium carbonate beim Kochen;

sodium chlorobiuret salt: sodium chlorobiuret salt

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
With ammonia; aluminum (III) chloride; zinc(II) chloride In water at 10 - 60℃; for 1h;	97%
With ammonia; aluminum (III) chloride; zinc(II) chloride In water at 10 - 60℃; for 1h;	96%
With ammonia; cadmium(II) chloride; zinc(II) chloride In water at 10 - 60℃; for 1h;	96%

: 108-19-0
BIURET

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
Stage #1: BIURET With sodium hypochlorite In water at 5 - 10℃; Stage #2: With ammonia; zinc(II) chloride In water at 100℃; for 0.5h; Product distribution / selectivity;	96%
Stage #1: BIURET With sodium hypochlorite In water at 5 - 10℃; Stage #2: With ammonia In water at 100℃; for 0.5h; Product distribution / selectivity;	95%
Stage #1: BIURET With sodium hypochlorite In ethanol; water at 5 - 10℃; Stage #2: With ammonia In ethanol; water at 100℃; for 0.5h; Product distribution / selectivity;	85%

: chlorobiuret sodium salt

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
With ammonia; zinc(II) chloride In water at 10 - 100℃; for 0.5h; Product distribution / selectivity;	93%
With ammonia; hydrogenchloride In water at 10 - 100℃; for 0.5h; Product distribution / selectivity;	92%
With ammonia; nickel diacetate In water at 10 - 100℃; for 0.5h; Product distribution / selectivity;	92%
With ammonia In water at 10 - 100℃; for 0.5h; Product distribution / selectivity;	87%

: 81824-93-3
(E)-2-(3,4,5-trimethoxybenzylidene)hydrazine carboxamide

A: 110-21-4
hydrazodicarboxamide

B: 7251-01-6
(1E, 2E)-1,2-bis(3,4,5-trimethoxybenzylidene)hydrazine

Conditions

Conditions	Yield
In tetrahydrofuran at 120 - 150℃; Rearrangement; elimination;	A n/a B 87%

: (E)-2-benzylidenehydrazine-1-carboxamide

A: 110-21-4
hydrazodicarboxamide

B: 28867-76-7
benzaldehyde benzylidenehydrazone

Conditions

Conditions	Yield
In tetrahydrofuran at 120 - 150℃; Rearrangement; elimination;	A n/a B 85%

: 16742-62-4
3,4-methylenedioxybenzaldehyde semicarbazone

A: 110-21-4
hydrazodicarboxamide

B: (2E,N'E)-3-(benzo[d][1,3]dioxol-5-yl)-N'-(benzo[d][1,3]dioxol-5-ylmethylene)-2-cyanoacrylohydrazide

Conditions

Conditions	Yield
In tetrahydrofuran at 120 - 150℃; Rearrangement; elimination;	A n/a B 84%

: 120445-53-6
(E)-2-(4-methoxybenzylidene)hydrazine carboxamide

A: 110-21-4
hydrazodicarboxamide

B: 41097-47-6
N,N'-Bis-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine

Conditions

Conditions	Yield
In tetrahydrofuran at 120 - 150℃; Rearrangement; elimination;	A n/a B 83%

: 2,4-dimethoxybenzaldehyde semicarbazone

A: 110-21-4
hydrazodicarboxamide

B: 134691-71-7
(1E,2E)-1,2-bis(3,4-dimethoxybenzylidene)hydrazine

Conditions

Conditions	Yield
In tetrahydrofuran at 120 - 150℃; Rearrangement; elimination;	A n/a B 68%

: 27991-08-8
N-acetoacetylphenylhydroxyloamine

A: 110-21-4
hydrazodicarboxamide

B: 100-65-2
N-Phenylhydroxylamine

C: 57303-41-0
1-carbamido-3-methyl-2-pyrazolin-5-one

D: 495-48-7
azoxybenzene

Conditions

Conditions	Yield
With semicarbazide hydrochloride; sodium carbonate In ethanol for 24h; Ambient temperature; Further byproducts given;	A 63% B 35% C 15.5% D 30%

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Chemistry

IUPAC Name: 1,2-Hydrazinedicarboxamide
The MF of 1,2-Hydrazinedicarboxamide (110-21-4) is C₂H₆N₄O₂.

The MW of 1,2-Hydrazinedicarboxamide (110-21-4) is 118.09.
Synonyms of 1,2-Hydrazinedicarboxamide (110-21-4): Hydrazine-1,2-dicarboxamide ; 1, 2-Hydrazinedicarboxamide ; 1,1'-Hydrazinebisformamide ; 1,1-Hydrazoformamide
Product Categories: Pharmaceutical Intermediates;Hydrazines,Hydrazones and Oximes
Apperance: White powder
Index of Refraction: 1.547
Density: 1.461 g/ml
EINECS: 203-747-2
Melting Point: 239-241 °C

Uses

1,2-Hydrazinedicarboxamide (110-21-4) is used as the production of ADC foaming agent.

Production

It is chemically classified as an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Toxicity Data With Reference

orl-rat LD50:>2 g/kg

ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. 15 (Suppl 1),(1996),S92.

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_x.Safety information of 1,2-Hydrazinedicarboxamide (110-21-4):
Risk Statements
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
24/25 Avoid contact with skin and eyes